Product name | Methyl acetoacetate |
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Product number | - |
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Other names | Methyl 3-oxobutanoate |
Identified uses | For industry use only. Food additives -> Flavoring Agents |
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Uses advised against | no data available |
Company | MOLBASE (Shanghai) Biotechnology Co., Ltd. |
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Address | Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, Xuhui District, Shanghai, China |
Telephone | +86(21)64956998 |
Fax | +86(21)54365166 |
Emergency phone number | +86-400-6021-666 |
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Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
Eye irritation, Category 2
2.2 GHS label elements, including precautionary statementsPictogram(s) | ![]() |
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Signal word | Warning |
Hazard statement(s) | H319 Causes serious eye irritation |
Precautionary statement(s) | |
Prevention | P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection. |
Response | P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. |
Storage | none |
Disposal | none |
none
3.Composition/information on ingredients 3.1 SubstancesChemical name | Common names and synonyms | CAS number | EC number | Concentration |
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Methyl acetoacetate | Methyl acetoacetate | 105-45-3 | none | 100% |
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaledFresh air, rest. Refer for medical attention.
In case of skin contactRemove contaminated clothes. Rinse skin with plenty of water or shower.
In case of eye contactFirst rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
If swallowedRinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayedMay be harmful by inhalation, ingestion, or skin absorption. Causes eye irritation. May cause skin irritation. (USCG, 1999)
4.3 Indication of immediate medical attention and special treatment needed, if necessaryBasic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/
5.Fire-fighting measures 5.1 Extinguishing media Suitable extinguishing media... /Use/ foam, carbon dioxide, dry chemical.
5.2 Specific hazards arising from the chemicalExcerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. Substance may be transported hot. For hybrid vehicles, ERG Guide 147 (lithium ion batteries) or ERG Guide 138 (sodium batteries) should also be consulted. If molten aluminum is involved, refer to ERG Guide 169. (ERG, 2016)
5.3 Special protective actions for fire-fightersWear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures 6.1 Personal precautions, protective equipment and emergency proceduresUse personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautionsPersonal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water.
6.3 Methods and materials for containment and cleaning upPick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.
7.Handling and storage 7.1 Precautions for safe handlingAvoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilitiesSeparated from oxidants.
8.Exposure controls/personal protection 8.1 Control parameters Occupational Exposure limit valuesno data available
Biological limit valuesno data available
8.2 Appropriate engineering controlsHandle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE) Eye/face protectionSafety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protectionWear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protectionWear dust mask when handling large quantities.
Thermal hazardsno data available
9.Physical and chemical propertiesPhysical state | Colorless liquid. |
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Colour | Colorless liquid |
Odour | Agreeable odor |
Melting point/ freezing point | -80ºC |
Boiling point or initial boiling point and boiling range | 169-170ºC |
Flammability | Combustible. |
Lower and upper explosion limit / flammability limit | no data available |
Flash point | 67ºC |
Auto-ignition temperature | 280°C (USCG, 1999) |
Decomposition temperature | no data available |
pH | no data available |
Kinematic viscosity | 1.704 cPa at 20°C |
Solubility | In water:460 g/L (20 ºC) |
Partition coefficient n-octanol/water (log value) | log Kow = -0.69 /Estimated/ |
Vapour pressure | 1.54mmHg at 25°C |
Density and/or relative density | 1.077 |
Relative vapour density | 4.0 (Air= 1) |
Particle characteristics | no data available |
no data available
10.2 Chemical stabilityMAA and EAA are stable liquids
10.3 Possibility of hazardous reactionsFIRE HAZARD: Moderate, when exposed to heat or flame.METHYL ACETOACETATE is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides
10.4 Conditions to avoidno data available
10.5 Incompatible materialsno data available
10.6 Hazardous decomposition productsWhen heated to decomposition it emits acrid smoke and irritating fumes
11.Toxicological information Acute toxicity- Oral: LD50 Rat oral 3.0 g/kg
- Inhalation: LC50 Rat inhalation >6.6 mg/L/4 hr
- Dermal: no data available
no data available
Serious eye damage/irritationno data available
Respiratory or skin sensitizationno data available
Germ cell mutagenicityno data available
Carcinogenicityno data available
Reproductive toxicityno data available
STOT-single exposureno data available
STOT-repeated exposureno data available
Aspiration hazardno data available
12.Ecological information 12.1 Toxicity- Toxicity to fish: LC50 Pimephales promelas (Fathead minnow) >111.4 mg/L/96 hr; static; temperature ranged from 19-20°C, pH ranged from 7.7 to 8.4 and dissolved oxygen ranged from 7.8 to 9.1 mg/L.
- Toxicity to daphnia and other aquatic invertebrates: EC50 Daphnia magna (Water flea; Acute immobilization test and reproduction) >236.9 mg/L/48 hr; static; exposure temperature ranged from 20-21°C, pH ranged from 7.9 to 8.3, and dissolved oxygen ranged from 8.7 to 8.9 mg/L
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
AEROBIC: Methyl acetoacetate, present at 100 mg/L, reached 78% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L and the Japanese MITI test(1). Methyl acetoacetate was degraded more than 90% in 2 days at 22°C using activated sludge inoculum in a Zahn-Wellens screening test(2).
12.3 Bioaccumulative potentialAn estimated BCF of 3.1 was calculated for methyl acetatoactate(SRC), using an estimated log Kow of -0.69(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soilUsing a structure estimation method based on molecular connectivity indices(1), the Koc for methyl acetoacetate can be estimated to be 1.0(SRC). According to a classification scheme(2), this estimated Koc value suggests that methyl acetoacetate is expected to have very high mobility in soil.
12.5 Other adverse effectsno data available
13.Disposal considerations 13.1 Disposal methods ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packagingContainers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information 14.1 UN NumberADR/RID: no data available | IMDG: no data available | IATA: no data available |
ADR/RID: no data available |
IMDG: no data available |
IATA: no data available |
ADR/RID: no data available | IMDG: no data available | IATA: no data available |
ADR/RID: no data available | IMDG: no data available | IATA: no data available |
ADR/RID: no | IMDG: no | IATA: no |
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Codeno data available
15.Regulatory information 15.1 Safety, health and environmental regulations specific for the product in questionChemical name | Common names and synonyms | CAS number | EC number |
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Methyl acetoacetate | Methyl acetoacetate | 105-45-3 | none |
European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
EC Inventory | Listed. | ||
United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
China Catalog of Hazardous chemicals 2015 | Not Listed. | ||
New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
Vietnam National Chemical Inventory | Listed. | ||
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. |
Creation Date | Aug 14, 2017 |
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Revision Date | Aug 14, 2017 |
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/