| Product name | acetone |
|---|
| Product number | - |
|---|---|
| Other names | Dimethylketal |
| Identified uses | For industry use only. Volatile organic compounds |
|---|---|
| Uses advised against | no data available |
| Company | MOLBASE (Shanghai) Biotechnology Co., Ltd. |
|---|---|
| Address | Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, Xuhui District, Shanghai, China |
| Telephone | +86(21)64956998 |
| Fax | +86(21)54365166 |
| Emergency phone number | +86-400-6021-666 |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
Flammable liquids, Category 2
Eye irritation, Category 2
Specific target organ toxicity – single exposure, Category 3
2.2 GHS label elements, including precautionary statements| Pictogram(s) |   |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H225 Highly flammable liquid and vapour H319 Causes serious eye irritation H336 May cause drowsiness or dizziness |
| Precautionary statement(s) | |
| Prevention | P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection. P264 Wash ... thoroughly after handling. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. |
| Response | P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P312 Call a POISON CENTER/doctor/…if you feel unwell. |
| Storage | P403+P235 Store in a well-ventilated place. Keep cool. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to ... |
none
3.Composition/information on ingredients 3.1 Substances| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| acetone | acetone | 67-64-1 | none | 100% |
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaledFresh air, rest. Refer for medical attention.
In case of skin contactRemove contaminated clothes. Rinse skin with plenty of water or shower.
In case of eye contactRinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention.
If swallowedRinse mouth. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayedINHALATION: vapor irritating to eyes and mucous membranes; acts as an anesthetic in very high concentrations. INGESTION: low order of toxicity but very irritating to mucous membranes. SKIN: prolonged excessive contact causes defatting of the skin, possibly leading to dermatitis. (USCG, 1999)
4.3 Indication of immediate medical attention and special treatment needed, if necessaryImmediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Ketones and related compounds/
5.Fire-fighting measures 5.1 Extinguishing media Suitable extinguishing mediaIf material is on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, carbon dioxide, or dry chemical.
5.2 Specific hazards arising from the chemicalExcerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)
5.3 Special protective actions for fire-fightersWear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures 6.1 Personal precautions, protective equipment and emergency proceduresUse personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautionsRemove all ignition sources. Personal protection: filter respirator for organic gases and vapours of low boiling point adapted to the airborne concentration of the substance. Ventilation. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer.
6.3 Methods and materials for containment and cleaning upAccidental release measures. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas.; Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains.; Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.
7.Handling and storage 7.1 Precautions for safe handlingAvoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilitiesFireproof. Separated from : see Chemical Dangers. Store in an area without drain or sewer access.Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): Flammable liquids
8.Exposure controls/personal protection 8.1 Control parameters Occupational Exposure limit valuesRecommended Exposure Limit: 10-hour Time-Weighted Average: 250 ppm (590 mg/cu m).
Biological limit valuesno data available
8.2 Appropriate engineering controlsHandle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE) Eye/face protectionSafety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protectionWear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protectionWear dust mask when handling large quantities.
Thermal hazardsno data available
9.Physical and chemical properties| Physical state | Clear liquid |
|---|---|
| Colour | Colorless volatile liquid |
| Odour | Fruity odor |
| Melting point/ freezing point | -95ºC |
| Boiling point or initial boiling point and boiling range | 56°C/760mmHg(lit.) |
| Flammability | Class IB Flammable Liquid: Fl.P. below 22.78°C and BP at or above 37.78°C.Highly flammable. |
| Lower and upper explosion limit / flammability limit | Lower flammable limit: 2.5% by volume; Upper flammable limit: 12.8% by volume |
| Flash point | -17°C |
| Auto-ignition temperature | 465°C (USCG, 1999) |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | 0.32 cP at 20°C; 0.27 cP at 40°C |
| Solubility | In water:soluble |
| Partition coefficient n-octanol/water (log value) | log Kow = -0.24 |
| Vapour pressure | 184 mm Hg ( 20 °C) |
| Density and/or relative density | 0.791g/mLat 25°C(lit.) |
| Relative vapour density | 2 (vs air) |
| Particle characteristics | no data available |
no data available
10.2 Chemical stabilityStable under recommended storage conditions.
10.3 Possibility of hazardous reactionsHighly flammable liquid. Dangerous disaster hazard due to fire and explosion hazard ...The vapour is heavier than air and may travel along the ground; distant ignition possible.It was reported that a mixture of ACETONE and chloroform, in a residue bottle, exploded. Since addition of acetone to chloroform in the presence of base will result in a highly exothermic reaction, it is thought that a base was in the bottle [MCA Case History 1661. 1970]. Also, Nitrosyl chloride, sealed in a tube with a residue of acetone in the presence of platinum catalyst, gave an explosive reaction [Chem. Eng. News 35(43):60. 1967]. The reaction of nitrosyl perchlorate and acetone ignites and explodes. Explosions occur with mixtures of nitrosyl perchlorate and primary amine [Ann. Chem. 42:2031. 1909]. Reacts violently with nitric acid. Also causes exothermic reaction when in contact with aldehydes.
10.4 Conditions to avoidno data available
10.5 Incompatible materialsIncompatible materials: Bases, Oxidizing agents, Reducing agents, Acetone reacts violently with phosphorous oxychloride.
10.6 Hazardous decomposition productsno data available
11.Toxicological information Acute toxicity- Oral: LD50 Rat oral 10.7 mL/kg (=8450 mg/kg bw)
- Inhalation: LC50 Rat inhalation exposure 76 mg/L/4 hr
- Dermal: no data available
no data available
Serious eye damage/irritationno data available
Respiratory or skin sensitizationno data available
Germ cell mutagenicityno data available
CarcinogenicityCancer Classification: Group D Not Classifiable as to Human Carcinogenicity
Reproductive toxicityno data available
STOT-single exposureno data available
STOT-repeated exposureno data available
Aspiration hazardno data available
12.Ecological information 12.1 Toxicity- Toxicity to fish: LC50; Species: /Oncorhynchus mykiss/ (Rainbow trout) weight 1.0 g; Conditions: /static/, 12°C; Concentration: 5,540 mg/L for 96 hr (95% confidence limit: 4,740-6,330 mg/L)
- Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna /(Water flea)/; Concentration: 10 mg/L for 24 to 48 hr /Conditions of bioassay not specified
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
AEROBIC: The percent theoretical BOD of acetone in water seeded with settled domestic sewage was 56%, 76%, 83% and 84%, over 5, 10, 15 and 20 day incubation periods(1). Percent theoretical BOD's of acetone in a raw sewage inocula were reported as 37% and 81% over 5 and 20 day incubation periods, respectively(2), 54% over a 5 day incubation period(3), 71% over a 7 day incubation period(4), 55% and 72% over 5 day and 10 day incubation periods respectively(5) and 38% over a 5 day incubation period(6). The percent theoretical BOD of acetone in freshwater was reported as 56%, 76%, 83% and 84% over 5, 10, 15 and 20 day incubation periods, respectively(7). The percent theoretical BOD of acetone in seawater was reported as 38%, 67%, 69% and 76% over 5, 10, 15 and 20 day incubation periods, respectively(7). Acetone, present at 100 mg/L, reached 96% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test which classified the compound as readily biodegradable(8). Using OECD Guideline 301B (Ready Biodegradability: CO2 Evolution Test), acetone was found to be readily biodegradable with 60% degradation after 5 days and 90.9% CO2 evolution after 28 days(9).
12.3 Bioaccumulative potentialAn estimated BCF of 3 was calculated in fish for acetone(SRC), using a log Kow of -0.24(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that the potential for bioconcentration in aquatic organisms is low(SRC). In a 1931 test report, a BCF value of 0.69 was determined for adult haddock fish over an 11 hour exposure period(4); however, the test protocol does not meet important criteria of current standard BCF methods(4).
12.4 Mobility in soilUsing a structure estimation method based on molecular connectivity indices(1), the Koc of acetone can be estimated to be 2.4(SRC). According to a classification scheme(2), this estimated Koc value suggests that acetone is expected to have very high mobility in soil. In sorption studies, acetone showed no adsorption to montorillonite, kaolinite clay, or stream sediment(3,4).
12.5 Other adverse effectsno data available
13.Disposal considerations 13.1 Disposal methods ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packagingContainers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information 14.1 UN Number| ADR/RID: UN1090 | IMDG: UN1090 | IATA: UN1090 |
| ADR/RID: ACETONE |
| IMDG: ACETONE |
| IATA: ACETONE |
| ADR/RID: 3 | IMDG: 3 | IATA: 3 |
| ADR/RID: II | IMDG: II | IATA: II |
| ADR/RID: no | IMDG: no | IATA: no |
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Codeno data available
15.Regulatory information 15.1 Safety, health and environmental regulations specific for the product in question| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| acetone | acetone | 67-64-1 | none |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Creation Date | Aug 16, 2017 |
|---|---|
| Revision Date | Aug 16, 2017 |
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
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