| Product name | 2-nitrooxyethyl nitrate |
|---|
| Product number | - |
|---|---|
| Other names | ethane-1,2-diyl dinitrate |
| Identified uses | For industry use only. |
|---|---|
| Uses advised against | no data available |
| Company | MOLBASE (Shanghai) Biotechnology Co., Ltd. |
|---|---|
| Address | Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, Xuhui District, Shanghai, China |
| Telephone | +86(21)64956998 |
| Fax | +86(21)54365166 |
| Emergency phone number | +86-400-6021-666 |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
Explosives, Unstable explosive
Acute toxicity - Oral, Category 2
Acute toxicity - Dermal, Category 1
Acute toxicity - Inhalation, Category 2
Specific target organ toxicity – repeated exposure, Category 2
2.2 GHS label elements, including precautionary statements| Pictogram(s) |    |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H200 Unstable explosive H300 Fatal if swallowed H310 Fatal in contact with skin H330 Fatal if inhaled H373 May cause damage to organs through prolonged or repeated exposure |
| Precautionary statement(s) | |
| Prevention | P201 Obtain special instructions before use. P250 Do not subject to grinding/shock/friction/…. P280 Wear protective gloves/protective clothing/eye protection/face protection. P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P262 Do not get in eyes, on skin, or on clothing. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P284 [In case of inadequate ventilation] wear respiratory protection. |
| Response | P370+P372+P380+P373 In case of fire: Explosion risk. Evacuate area. DO NOT fight fire when fire reaches explosives. P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/… P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P310 Immediately call a POISON CENTER/doctor/… P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P320 Specific treatment is urgent (see ... on this label). P314 Get medical advice/attention if you feel unwell. |
| Storage | P401 Store in accordance with… P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed. |
| Disposal | P501 Dispose of contents/container to ... |
none
3.Composition/information on ingredients 3.1 Substances| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 2-nitrooxyethyl nitrate | 2-nitrooxyethyl nitrate | 628-96-6 | none | 100% |
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaledFresh air, rest. Refer for medical attention.
In case of skin contactRemove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
In case of eye contactFirst rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
If swallowedRinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayedExposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Throbbing headache; dizziness; nausea, vomiting, abdominal pain; hypotension, flush, palpitations, angina; methemoglobinemia; delirium, central nervous system depression; irritation skin Target Organs: Skin, cardiovascular system, blood, liver, kidneys (NIOSH, 2016)
4.3 Indication of immediate medical attention and special treatment needed, if necessary/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Nitrates, nitrites, and related compounds/
5.Fire-fighting measures 5.1 Extinguishing media Suitable extinguishing mediaEvacuate area of fire ... Fight fires only from a secure, explosion-resistant position ... Use dry chemical, carbon dioxide, water spray, or foam extinguishers. Vapors are heavier than air and will collect in low areas. Vapors may travel long distances to ignition sources and flashback. Vapors in confined areas may explode when exposed to fire. Containers may explode in fire. Storage containers and parts of containers may rocket great distances, in many directions. If material or contaminated runoff enters waterways, notify downstream health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors or shows any signs of deforming), withdraw immediately to a secure position.
5.2 Specific hazards arising from the chemicalno data available
5.3 Special protective actions for fire-fightersWear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures 6.1 Personal precautions, protective equipment and emergency proceduresUse personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautionsEvacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning upSpread sodium bisulfate over the area and sprinkle with water. Then flush to sewer with water. Evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Ventilate area of spill or leak. Absorb liquids in vermiculite, dry sand, earth, peat, carbon, or a similar material and deposit in sealed containers. Keep EGDN out of a confined space, such as a sewer, because of the possibility of an explosion, unless the sewer is designed to prevent the build-up of explosive concentrations. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental protection or your regional office of the federal EPA for specific recommendations.
7.Handling and storage 7.1 Precautions for safe handlingAvoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilitiesFireproof. Store in a separate building. Separated from acids and food and feedstuffs. Cool. Well closed.Buildings used for storage of nitroglycerin or ethylene glycol dinitrate shall be separated by at least the minimum distances required; containers of nitroglycerin or ehylene glycol dinitrate shall be kept tightly closed at all times when not in use and shall be stored in a manner that will minimized the risk of spills; only properly informed, trained, and equipped personnel shall be involved in storing, loading, and unloading, or processing liquid nitroglycerin, ethylene glycol dinitrate, or explosive mixtures containing these compounds. Also, storage areas for nitroglycerin or ethylene glycol dinitrate shall be clean, dry, and well ventilated. Storage areas for explosive forms of nitroglycerin or ethylene glycol dinitrate shall be in a structure that is bullet resistant, weather resistant, and ventilated.
8.Exposure controls/personal protection 8.1 Control parameters Occupational Exposure limit valuesCeiling limit: 0.1 mg/cu m/20 min
NIOSH has concluded that workplace exposure to nitroglycerin and EGDN should be controlled so that workers are not exposed at concentrations that will cause vasodilation, as indicated by the development of throbbing headaches or decreases in blood pressure. This standard should also protect against the development of angina pectoris, other signs or symptoms of cardiac ischemia or heart damage, and against sudden death, as a result of working with nitroglycerin or ethylene glycol dinitrate and revealed by withdrawal to the vasodilatory activity of these substances during weekends or other periods of absence from regular exposure.
Recommended Exposure Limit: 15 Minute Short-Term Exposure Limit: 0.1 mg/cu m. Skin.
Biological limit valuesno data available
8.2 Appropriate engineering controlsHandle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE) Eye/face protectionSafety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protectionWear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protectionWear dust mask when handling large quantities.
Thermal hazardsno data available
9.Physical and chemical properties| Physical state | Ethylene glycol dinitrate is a colorless to yellow, oily odorless liquid with a sweetish taste. Mp: -22°C; bp: explodes at 114°C. Density: 1.49 g cm-3. Soluble in water (23.3 g/L H2O) at 25°C). Very soluble in ethanol and in ether. Used as an explosive ingredient in dynamite along with nitroglycerine. Toxic; can penetrate the skin. |
|---|---|
| Colour | Colorless to yellow, oily ... liquid [Note: An explosive ingredient (60-80%) in dynamite along with nitroglycerine (40-20%)]. |
| Odour | Odorless |
| Melting point/ freezing point | --13.33°C (NIOSH, 2016) |
| Boiling point or initial boiling point and boiling range | 197.22°C at 760 mm Hg (NIOSH, 2016) |
| Flammability | Explosive LiquidGives off irritating or toxic fumes (or gases) in a fire. |
| Lower and upper explosion limit / flammability limit | no data available |
| Flash point | 215°C (NIOSH, 2016) |
| Auto-ignition temperature | no data available |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | 4.2 mPa.s at 20°C |
| Solubility | Insoluble (NIOSH, 2016) |
| Partition coefficient n-octanol/water (log value) | log Kow = 1.16 |
| Vapour pressure | 0.05 mm Hg (NIOSH, 2016) |
| Density and/or relative density | 1.49 (NIOSH, 2016) |
| Relative vapour density | 5.25 (Air = 1) |
| Particle characteristics | no data available |
no data available
10.2 Chemical stabilityStable under recommended storage conditions.
10.3 Possibility of hazardous reactionsCombustible liquid.ETHYLENE GLYCOL DINITRATE is explosive. Acts as a strong oxidizing agent. Heating to 114°C or above may cause a violent combustion or explosion producing toxic fumes (nitrogen oxides). May also decompose explosively from shock, friction or from a build-up of electrostatic charge that sparks suddenly to ground. Can begin a vigorous reaction that culminates in an explosion if mixed with reducing agents including hydrides, sulfides, and nitrides and numerous ordinary combustible materials. Reacts violently with Al, BP, cyanides, esters, PN2H, P, NaCN, SnCl2, sodium hypophosphite, and thiocyanates. Reacts with acids and with alkalis, including ammonia and amines. Must be stored in a cool, ventilated place, away from acute fire hazards and easily oxidized materials (Sax and Lewis, 1987 p.664).
10.4 Conditions to avoidno data available
10.5 Incompatible materialsNot compatible with strong acids and alkalies.
10.6 Hazardous decomposition products... Decomposes violently upon heating or impact with a force similar to that of nitroglycerin.
11.Toxicological information Acute toxicity- Oral: LD50 Rat oral 616 mg/kg
- Inhalation: no data available
- Dermal: no data available
no data available
Serious eye damage/irritationno data available
Respiratory or skin sensitizationno data available
Germ cell mutagenicityno data available
Carcinogenicityno data available
Reproductive toxicityno data available
STOT-single exposureno data available
STOT-repeated exposureno data available
Aspiration hazardno data available
12.Ecological information 12.1 Toxicity- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
PURE CULTURE: Ethylene glycol dinitrate was biodegraded to ethylene glycol mononitrate at a rate of 6.32 umol/hr/mg by Klebsiella oxytoca(1).
12.3 Bioaccumulative potentialAn estimated BCF of 3 was calculated in fish for ethylene glycol dinitrate(SRC), using a log Kow of 1.16(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soilUsing a structure estimation method based on molecular connectivity indices(1), the Koc of ethylene glycol dinitrate can be estimated to be 40(SRC). According to a classification scheme(2), this estimated Koc value suggests that ethylene glycol dinitrate is expected to have very high mobility in soil.
12.5 Other adverse effectsno data available
13.Disposal considerations 13.1 Disposal methods ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packagingContainers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information 14.1 UN Number| ADR/RID: no data available | IMDG: no data available | IATA: no data available |
| ADR/RID: no data available |
| IMDG: no data available |
| IATA: no data available |
| ADR/RID: no data available | IMDG: no data available | IATA: no data available |
| ADR/RID: no data available | IMDG: no data available | IATA: no data available |
| ADR/RID: no | IMDG: no | IATA: no |
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Codeno data available
15.Regulatory information 15.1 Safety, health and environmental regulations specific for the product in question| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| 2-nitrooxyethyl nitrate | 2-nitrooxyethyl nitrate | 628-96-6 | none |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Not Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Not Listed. | ||
| Vietnam National Chemical Inventory | Not Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Not Listed. | ||
| Creation Date | Aug 19, 2017 |
|---|---|
| Revision Date | Aug 19, 2017 |
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
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