| Product name | 1,2-epoxypropane |
|---|
| Product number | - |
|---|---|
| Other names | 2-methyloxirane |
| Identified uses | For industry use only. The major use of propylene oxide is in the production of polyethers (the primary component of polyurethane foams) and propylene glycol. Propylene oxide is also used in the fumigation of foodstuffs and plastic medical instruments and in the manufacture of dipropylene glycol and glycol ethers, as herbicides, as solvents, and in the preparation of lubricants, surfactants, and oil demulsifiers. |
|---|---|
| Uses advised against | no data available |
| Company | MOLBASE (Shanghai) Biotechnology Co., Ltd. |
|---|---|
| Address | Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, Xuhui District, Shanghai, China |
| Telephone | +86(21)64956998 |
| Fax | +86(21)54365166 |
| Emergency phone number | +86-400-6021-666 |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
Flammable liquids, Category 1
Acute toxicity - Oral, Category 4
Acute toxicity - Dermal, Category 3
Eye irritation, Category 2
Acute toxicity - Inhalation, Category 3
Specific target organ toxicity – single exposure, Category 3
Germ cell mutagenicity, Category 1B
Carcinogenicity, Category 1B
2.2 GHS label elements, including precautionary statements| Pictogram(s) |    |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H224 Extremely flammable liquid and vapour H302 Harmful if swallowed H311 Toxic in contact with skin H319 Causes serious eye irritation H331 Toxic if inhaled H335 May cause respiratory irritation H340 May cause genetic defects H350 May cause cancer |
| Precautionary statement(s) | |
| Prevention | P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection. P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. |
| Response | P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P312 Call a POISON CENTER/doctor/…if you feel unwell. P321 Specific treatment (see ... on this label). P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P311 Call a POISON CENTER/doctor/… P308+P313 IF exposed or concerned: Get medical advice/ attention. |
| Storage | P403+P235 Store in a well-ventilated place. Keep cool. P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed. |
| Disposal | P501 Dispose of contents/container to ... |
none
3.Composition/information on ingredients 3.1 Substances| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 1,2-epoxypropane | 1,2-epoxypropane | 75-56-9 | none | 100% |
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaledFresh air, rest. Seek medical attention if you feel unwell.
In case of skin contactRemove contaminated clothes. Rinse skin with plenty of water or shower.
In case of eye contactRinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention.
If swallowedRinse mouth. Do NOT induce vomiting. Refer for medical attention if breathing difficulties and/or fever develop.
4.2 Most important symptoms/effects, acute and delayedThis material is moderately toxic by inhalation and ingestion. It may cause irreversible and reversible changes. Skin contact with the material or solutions of the material cause irritation; diluted solutions are more irritating than undiluted materials. Exposure may cause mild depression of the central nervous system and eye, nasal, and lung irritation. Contact with the liquid can cause blindness and death. Pulmonary edema may recur up to 2 weeks after exposure. (EPA, 1998)
4.3 Indication of immediate medical attention and special treatment needed, if necessaryBasic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Provide a low-stimulus environment. Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Treat frostbite by rapid rewarming ... . /Ethers and related compounds/
5.Fire-fighting measures 5.1 Extinguishing media Suitable extinguishing mediaIf material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as a fog. Solid streams of water may be ineffective. Cool all effective containers with flooding quantities of water. Apply water from as far away as possible. Use "alcohol" foam, dry chemical or carbon dioxide.
5.2 Specific hazards arising from the chemicalVapor is heavier than air and may travel considerable distance to source of ignition and flash back. Vapors form explosive mixture with air. If polymerization takes place in container, there may be a violent rupture of container. Explosion hazard is severe when exposed to flame. Violently reacts with acetylide- forming metals such as copper or copper alloys, ammonium hydroxide; chlorosulfonic acid; hydrochloric acid; hydrofluoric acid; nitric acid; oleum and sulfuric acid. Hazardous polymerization may occur. Avoid active catalytic surfaces such as anhydrous chlorides of iron, tin, and aluminum; peroxides of iron and aluminum; and alkali metal hydroxides, high temperatures; alkalies; aqueous acids; amines and acidic alcohols. (EPA, 1998)
5.3 Special protective actions for fire-fightersWear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures 6.1 Personal precautions, protective equipment and emergency proceduresUse personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautionsEvacuate danger area! Consult an expert! Remove all ignition sources. Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Collect leaking liquid in sealable dry containers. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning upEvacuation: If material leaking (not on fire) consider evacuation from downwind area based on amount of material spilled, location and weather conditions.
7.Handling and storage 7.1 Precautions for safe handlingAvoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilitiesFireproof. Separated from acids, bases and strong oxidants. Dry. Cool. Well closed. Keep in the dark.Use glass or metal containers sealed with nitrogen.
8.Exposure controls/personal protection 8.1 Control parameters Occupational Exposure limit valuesNIOSH considers propylene oxide to be a potential occupational carcinogen.
NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concentration.
Biological limit valuesno data available
8.2 Appropriate engineering controlsHandle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE) Eye/face protectionSafety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protectionWear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protectionWear dust mask when handling large quantities.
Thermal hazardsno data available
9.Physical and chemical properties| Physical state | colourless liquid with an ether-like odour |
|---|---|
| Colour | Colorless liquid ... [Note: A gas above 94 degrees F.] |
| Odour | ODOR IS SWEET, ALCOHOLIC, & LIKE ETHER OR BENZENE |
| Melting point/ freezing point | -112ºC |
| Boiling point or initial boiling point and boiling range | 34°C(lit.) |
| Flammability | Class IA Flammable Liquid: Fl.P. below 22.78°C and BP below 37.78°C.Extremely flammable. Heating will cause rise in pressure with risk of bursting. |
| Lower and upper explosion limit / flammability limit | Lower flammable limit: 2.3% by volume; Upper flammable limit: 36% by volume |
| Flash point | -37°C |
| Auto-ignition temperature | 747.78°C |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | 0.28 centipoise at 25°C |
| Solubility | greater than or equal to 100 mg/mL at 18.89°C |
| Partition coefficient n-octanol/water (log value) | log Kow= 0.03. |
| Vapour pressure | 445 mm Hg at 20°C (EPA, 1998) |
| Density and/or relative density | 0.83g/mLat 25°C(lit.) |
| Relative vapour density | 2 (vs air) |
| Particle characteristics | no data available |
no data available
10.2 Chemical stabilityIt polymerizes exothermically.
10.3 Possibility of hazardous reactionsFLAMMABLE, DANGEROUS FIRE RISKThe vapour is heavier than air and may travel along the ground; distant ignition possible. As a result of flow, agitation, etc., electrostatic charges can be generated.1,3-PROPYLENE OXIDE react with oxidizing agents and strong acids . Reacts with Grignard reagents and organolithium compounds. An explosion occurred when propylene oxide was added to an epoxy resin. It was concluded that polymerization was catalyzed by an amine accelerator in the resin [Bretherick, 5th Ed., 1995]. Underwent polymerization when mixed with sodium hydroxide causing ignition and explosion of a drum of the crude product. [Combust Sci. Technol., 1983].
10.4 Conditions to avoidno data available
10.5 Incompatible materialsNo acetylide-forming metals such as copper or copper alloys should be in contact with propylene oxide.
10.6 Hazardous decomposition productsWhen heated to decomposition it emits acrid smoke and fumes.
11.Toxicological information Acute toxicity- Oral: LD50 Guinea pig /oral/ 0.69 g/kg
- Inhalation: LC50 Mouse inhalation 1740 ppm/4 hr
- Dermal: LD50 Rabbit percutaneous 1.5 ml/kg
no data available
Serious eye damage/irritationno data available
Respiratory or skin sensitizationno data available
Germ cell mutagenicityno data available
CarcinogenicityCancer Classification: Group B2 Probable Human Carcinogen
Reproductive toxicityNo information is available on the reproductive or developmental effects of propylene oxide in humans. A study with rats and rabbits exposed to propylene oxide by inhalation prior to and during gestation concluded that propylene oxide was harmful to the developing fetus but did not cause birth defects. In rats, some degree of fetotoxicity was observed in all exposed groups (including a significant reduction in the number of corpora lutea, implants, and live fetuses) and minor skeletal malformations in some; there was no maternal mortality. Increased resorptions per litter were observed in rabbits.
STOT-single exposureno data available
STOT-repeated exposureno data available
Aspiration hazardno data available
12.Ecological information 12.1 Toxicity- Toxicity to fish: TLm Bluegill 215 mg/l/96 hr at 24°C, static bioassasy.
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
AEROBIC: 1,2-Propylene oxide, present at 100 mg/l, reached 95% of its theoretical BOD in 3 weeks using an activated sludge inoculum at 30 mg/l and the Japanese MITI test(1); therefore, this compound is expected to biodegrade rapidly. In another study, using the standard dilution method, a 5 day theoretical BOD of 8% was measured for propylene oxide using a filtered effluent seed from a biological sanitary waste treatment plant while a 5 day theoretical BOD of 9% was measured using an adapted seed(2).
12.3 Bioaccumulative potentialAn estimated BCF of 3 was calculated for 1,2-propylene oxide(SRC), using a log Kow of 0.03(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soilThe Koc of 1,2-propylene oxide is estimated as 25(SRC), using a measured log Kow of 0.03(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 1,2-propylene oxide is expected to have very high mobility in soil(SRC).
12.5 Other adverse effectsno data available
13.Disposal considerations 13.1 Disposal methods ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packagingContainers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information 14.1 UN Number| ADR/RID: UN1280 | IMDG: UN1280 | IATA: UN1280 |
| ADR/RID: PROPYLENE OXIDE |
| IMDG: PROPYLENE OXIDE |
| IATA: PROPYLENE OXIDE |
| ADR/RID: unknown | IMDG: unknown | IATA: unknown |
| ADR/RID: unknown | IMDG: unknown | IATA: unknown |
| ADR/RID: no | IMDG: no | IATA: no |
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Codeno data available
15.Regulatory information 15.1 Safety, health and environmental regulations specific for the product in question| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| 1,2-epoxypropane | 1,2-epoxypropane | 75-56-9 | none |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Creation Date | Aug 16, 2017 |
|---|---|
| Revision Date | Aug 16, 2017 |
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
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