| Product name | EPN |
|---|
| Product number | - |
|---|---|
| Other names | Santox |
| Identified uses | For industry use only. Insecticide |
|---|---|
| Uses advised against | no data available |
| Company | MOLBASE (Shanghai) Biotechnology Co., Ltd. |
|---|---|
| Address | Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, Xuhui District, Shanghai, China |
| Telephone | +86(21)64956998 |
| Fax | +86(21)54365166 |
| Emergency phone number | +86-400-6021-666 |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
Acute toxicity - Oral, Category 2
Acute toxicity - Dermal, Category 1
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
2.2 GHS label elements, including precautionary statements| Pictogram(s) |   |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H300 Fatal if swallowed H310 Fatal in contact with skin H410 Very toxic to aquatic life with long lasting effects |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P262 Do not get in eyes, on skin, or on clothing. P280 Wear protective gloves/protective clothing/eye protection/face protection. P273 Avoid release to the environment. |
| Response | P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/… P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P310 Immediately call a POISON CENTER/doctor/… P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P391 Collect spillage. |
| Storage | P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to ... |
none
3.Composition/information on ingredients 3.1 Substances| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| EPN | EPN | 2104-64-5 | none | 100% |
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaledFresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.
In case of skin contactRemove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention. Wear protective gloves when administering first aid. Put clothes in sealable container. See Notes.
In case of eye contactRinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.
If swallowedRinse mouth. Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention.
4.2 Most important symptoms/effects, acute and delayedThis material may be fatal if swallowed. It is poisonous if inhaled and extremely hazardous by skin contact. Repeated exposure may, without symptoms, be increasingly hazardous. The estimated fatal oral dose is 0.3 grams for a 150 lb. (70 kg) person. (EPA, 1998)
4.3 Indication of immediate medical attention and special treatment needed, if necessaryBasic treatment: Establish a patent airway. Suction if necessary. Aggressive airway control may be needed. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Organophosphates and related compounds/
5.Fire-fighting measures 5.1 Extinguishing media Suitable extinguishing mediaSelf contained breathing apparatus with a full facepiece operated in pressure demand, or other positive pressure mode /should be used in firefighting/. /Parathion/
5.2 Specific hazards arising from the chemical(Non-Specific -- Organophosphorus Pesticide, n.o.s.) This material may burn but does not ignite readily. Container may explode in heat of fire. Fire and runoff from fire control water may produce irritating or poisonous gases. Avoid strong oxidizers. Hydrolyzed by alkali. (EPA, 1998)
5.3 Special protective actions for fire-fightersWear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures 6.1 Personal precautions, protective equipment and emergency proceduresUse personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautionsPersonal protection: complete protective clothing including self-contained breathing apparatus. Do NOT wash away into sewer. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.
6.3 Methods and materials for containment and cleaning up1) Ventilate area of spill. 2) Cover with soda ash, mix and spray with water. Place in container of water and allow to stand for two days, then neutralize with 6 molar hydrogen chloride.
7.Handling and storage 7.1 Precautions for safe handlingAvoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilitiesSeparated from strong oxidizers and food and feedstuffs. Well closed. Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access.Keep away from heat and open flame. Keep container closed. Store at 65-100 deg F.
8.Exposure controls/personal protection 8.1 Control parameters Occupational Exposure limit valuesRecommended Exposure Limit: 10 Hr Time-Weighted Avg: 0.5 mg/cu m, skin.
Biological limit valuesno data available
8.2 Appropriate engineering controlsHandle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE) Eye/face protectionSafety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protectionWear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protectionWear dust mask when handling large quantities.
Thermal hazardsno data available
9.Physical and chemical properties| Physical state | often supplied as a solution in acetonitrile. |
|---|---|
| Colour | Light yellow crystals |
| Odour | Aromatic odor |
| Melting point/ freezing point | 36ºC |
| Boiling point or initial boiling point and boiling range | 215°C @ 5 mm Hg |
| Flammability | Noncombustible SolidCombustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire. |
| Lower and upper explosion limit / flammability limit | no data available |
| Flash point | 2ºC |
| Auto-ignition temperature | no data available |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | Insoluble (NIOSH, 2016) |
| Partition coefficient n-octanol/water (log value) | log Kow= 4.78 |
| Vapour pressure | 1.91E-08mmHg at 25°C |
| Density and/or relative density | 1.27 |
| Relative vapour density | no data available |
| Particle characteristics | no data available |
no data available
10.2 Chemical stabilityStable in neutral and acidic media but hydrolyzed by alkali to liberate p-nitrophenol.
10.3 Possibility of hazardous reactionsOrganophosphates, such as EPN, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
10.4 Conditions to avoidno data available
10.5 Incompatible materialsStrong oxidizers
10.6 Hazardous decomposition productsThe substance decomposes under influence of alkalies (hydrolysis) forming p-nitrophenol
11.Toxicological information Acute toxicity- Oral: LD50 Rat (female) oral 8 mg/kg
- Inhalation: LC50 Rat inhalation 160 mg/cu m/1 hr
- Dermal: LD50 Rat male percutaneous 2850 mg/kg
no data available
Serious eye damage/irritationno data available
Respiratory or skin sensitizationno data available
Germ cell mutagenicityno data available
CarcinogenicityA4; Not classifiable as a human carcinogen.
Reproductive toxicityno data available
STOT-single exposureno data available
STOT-repeated exposureno data available
Aspiration hazardno data available
12.Ecological information 12.1 Toxicity- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
AEROBIC: EPN, present at 100 mg/l, reached 3% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/l and the Japanese MITI test(1). Field dissipation half-lives ranging from 28 to 56 days have been reported(2). The half-life of 14C-labeled EPN in field tests with Dundee silt loam (pH 5.5, organic matter 1.3%) and Keyport silt loam (pH 6.4, organic matter 2.75%) were 2 weeks and 1 month, respectively(3) Greater than 90% of the residual radiolabeled carbon was found in the top 3 inches of soil, after 18 months, indicating no leaching of EPN or its degradation products had occurred(3). Under greenhouse conditions 14C-labeled EPN has a half-life of 5-6 weeks in Fallsington sandy loam soil (pH 5.6, organic matter 1.4%)(3). In a biometer study with Keyport silt loam half-lives were 5 and 6 weeks at 2 and 10 ppm, respectively(3). Breakdown of EPN in soil proceeded primarily through hydrolysis and oxidation to phenylphosphonic acid, followed by further degradation of the phenyl ring to CO2(3). Under laboratory conditions, the half-life of 1 ppm EPN in upland soil was 30-90 days and in submerged soil it was 3-15 days(4). In upland soils, degradation products were EPN-oxon, desethyl EPN-oxon, O-ethyl S-methylphenylphosphonothiolate, p-nitrophenol, O-ethyl O-methylphenylphosphonate, O-ethylphenylphosphonate, and phenylphosphonic acid(4).
12.3 Bioaccumulative potentialBCF values of 2,346(1), 700(2), 2,100 to 7,700(3), 358 to 1590(4), 1682(5), 495(6) to 1205(7), 929 to 1116(7), 641(7), 376(7) in topmouth gudgeon, pinfish, adult sheepshead minnow, carp, willow shiner, killifish, guppy, goldfish, and white cloud mountain fish, respectively, have been reported. According to a classification scheme(8), these BCF values suggest the potential for bioconcentration in aquatic organisms is high to very high(SRC). Although EPN can be bioconcentrated in aquatic organisms, it is also rapidly depurated(2). Pinfish exposed to 2.4 ug/l EPN, bioconcentrated the compound rapidly, reaching an apparent steady-state in approximately 2 days(2). After a 4-day post-exposure period only 1 out of 4 pinfish had detectable levels of EPN (0.04 g/g) in its tissues and after 8 days EPN was not detected in any fish(2). EPN was applied to sorghum leaves in a terrestrial-aquatic model ecosystem containing salt marsh catepillars, mosquito larvae, plankton, alga, snails and fish. After 33 days the values for bioaccumulation or ecological magnification in snail and fish were reported as 12,561 and 346, respectively(3).
12.4 Mobility in soilKoc values, measured at concentrations of 0.01, 0.1 and 1.0 ppm EPN, were 1,997 and 706 for a clay loam and a high clay soil, respectively, with a mean of 1,327(1). According to a classification scheme(2), these Koc values suggest that EPN is expected to have low mobility in soil. In field tests with Dundee silt loam (pH 5.5, organic matter 1.3%) and Keyport silt loam (pH 6.4, organic matter 2.75%), greater than 90% of the residual radiolabeled carbon was found in the top 3 inches of soil, after 18 months, indicating no leaching of EPN or its degradation products had occurred(3).
12.5 Other adverse effectsno data available
13.Disposal considerations 13.1 Disposal methods ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packagingContainers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information 14.1 UN Number| ADR/RID: UN3018 | IMDG: UN3018 | IATA: UN3018 |
| ADR/RID: ORGANOPHOSPHORUS PESTICIDE, LIQUID, TOXIC |
| IMDG: ORGANOPHOSPHORUS PESTICIDE, LIQUID, TOXIC |
| IATA: ORGANOPHOSPHORUS PESTICIDE, LIQUID, TOXIC |
| ADR/RID: 6.1(a) | IMDG: 6.1(a) | IATA: 6.1(a) |
| ADR/RID: II | IMDG: II | IATA: II |
| ADR/RID: yes | IMDG: yes | IATA: yes |
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Codeno data available
15.Regulatory information 15.1 Safety, health and environmental regulations specific for the product in question| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| EPN | EPN | 2104-64-5 | none |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Not Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Not Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Not Listed. | ||
| Vietnam National Chemical Inventory | Not Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Not Listed. | ||
| Creation Date | Aug 14, 2017 |
|---|---|
| Revision Date | Aug 14, 2017 |
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
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