辛酰溴苯腈

Acute toxicity - Oral, Category 4

Skin sensitization, Category 1

Acute toxicity - Inhalation, Category 3

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

Reproductive toxicity, Category 2

Pictogram(s)
Signal word	Danger
Hazard statement(s)	H302 Harmful if swallowed H317 May cause an allergic skin reaction H331 Toxic if inhaled H410 Very toxic to aquatic life with long lasting effects H361d
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P280 Wear protective gloves/protective clothing/eye protection/face protection. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood.
Response	P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P333+P313 If skin irritation or rash occurs: Get medical advice/attention. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P311 Call a POISON CENTER/doctor/… P391 Collect spillage. P308+P313 IF exposed or concerned: Get medical advice/ attention.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

none

Consult a physician. Show this safety data sheet to the doctor in attendance.

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

Wash off with soap and plenty of water. Consult a physician.

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/

If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use "alcohol" foam, dry chemical or carbon dioxide.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways. (ERG, 2016)

Wear self-contained breathing apparatus for firefighting if necessary.

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

Environmental considerations: Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

Handle carefully ... Do not use or store near heat or open flame. Store at temperature above 3 deg F. If allowed to freeze, remix before using. Do not contaminate water, food or feed by storage or disposal of this chemical.

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Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Wear dust mask when handling large quantities.

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Susceptible to hydrolysis by acids and alkalis.

BROMOXYNIL OCTANOATE, [SOLID] is an ester. Readily hydrolyzed to bromoxynil and octanoate at pH's exceeding 9.

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When heated to decomposition it emits toxic fumes of /nitrogen oxide and hydrogen bromide/.

• Oral: LD50 Mouse oral 245 mg/kg
• Inhalation: no data available
• Dermal: no data available

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• Toxicity to fish: LC50 Lepomis macrochirus (Bluegill) 61 ppb/96 hr (95% confidence interval: 48-79 ppb); static /formulated product
• Toxicity to daphnia and other aquatic invertebrates: EC50 Daphnia magna (Water flea, varying life stages; intoxication, immobilization) 41-161 ug/L/48 hr; static /formulated product
• Toxicity to algae: no data available
• Toxicity to microorganisms: no data available

14C-Labeled bromoxynil octanoate was reported to degrade in sandy loam soil with a half-life of 2 days; the major degradation product was CO2, which accounted for 64.28% of the applied radioactivity after 90 days(1). In soil photolysis experiments, bromoxylnil octanoate was found to degrade with a half-life of 2.6 days when irradiated with a xenon arc lamp; a degradation half-life of 3.6 days was observed in a dark control(1). Degradation in the dark control suggests that degradation processes in addition to photolysis (e.g., hydrolysis or microbial degradation) were occurring(1). A half-life of <12 hrs was reported when treated sandy loam soil was flooded with pond water and then aerobically incubated; test compound concn was 87% of applied at time zero, declining to undetectable levels in 48 hrs(1). Field dissipation half-lives ranging from 0.5 to 28 days have been reported(2). In degradation experiments using 5 soil types (sandy loam, acid sand, organic silt, sandy loam, and clay) in a soil perfusion apparatus and C14 (cyano) bromoxynil octanoate half-lives ranged from 7 to 22 days(3). In experiments using C14 (ring) bromoxynil octanoate half-live ranged from 10-12 days in clay and sandy loam soils(3). The degradation of bromoxynil octanoate in two soils, a heavy clay and a sandy loam, at 85% of field capacity moisture and at 20°C, was studied(4). In both soils bromoxynil octanoate was rapidly degraded to bromoxynil, which was then also rapidly degraded; after 7 days >90% of the original application had disappeared(4). Three pesticides, including bromoxynil octanoate, were applied to two field plots in Saskatchewan; after 10 weeks none of the pesticides could be detected in the top 10 cm of soil(4). Bromoxynil octanoate was reported to degrade with a half-life of 3.7 days in a sandy loam sediment under anaerobic conditions(1). The environmental fate of bromoxynil octanoate was investigated in small ponds in the wetland area of the Delta Waterfowl and Wetlands Research Station in Canada(5). Bromoxynil octanoate, along with bromoxynil butyrate were sprayed on the ponds; sampling showed that bromoxynil octanoate persisted in the surface microlayer (0-1 mm) with half-lives of 0.8-2.5 hours(5). In subsurface waters (10-20 cm depth) the major forms of the pesticides were bromoxynil (phenol) and its monobromo analog(5).

A BCF of 230 (whole fish) was reported in bluegill sunfish when continuously exposed to 14C radiolabeled bromoxynil octanoate at 1.3-4.6 ug/L(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is high, provided the compound is not metabolized by the organism(SRC).

The Koc of bromoxynil octanoate is estimated as 21,000(SRC), using a log Kow of 5.4(1)and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that bromoxynil ocatonate is expected to be immobile mobility in soil. In an aged soil leaching study, bromoxynil octanoate residues were found to not be mobile in four soils and aquatic sediment(4). A Kd of 7 mL/g (Koc = 1,003) was reported in soils with 1.2% organic matter(4).

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The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

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• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/