| Product name | 1,3-dichloropropene |
|---|
| Product number | - |
|---|---|
| Other names | E/Z-1,3-Dichloropropene |
| Identified uses | For industry use only. Volatile organic compounds |
|---|---|
| Uses advised against | no data available |
| Company | MOLBASE (Shanghai) Biotechnology Co., Ltd. |
|---|---|
| Address | Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, Xuhui District, Shanghai, China |
| Telephone | +86(21)64956998 |
| Fax | +86(21)54365166 |
| Emergency phone number | +86-400-6021-666 |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
Flammable liquids, Category 3
Acute toxicity - Oral, Category 3
Acute toxicity - Dermal, Category 3
Skin irritation, Category 2
Eye irritation, Category 2
Skin sensitization, Category 1
Acute toxicity - Inhalation, Category 4
Aspiration hazard, Category 1
Specific target organ toxicity – single exposure, Category 3
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
2.2 GHS label elements, including precautionary statements| Pictogram(s) |     |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H226 Flammable liquid and vapour H301 Toxic if swallowed H311 Toxic in contact with skin H315 Causes skin irritation H319 Causes serious eye irritation H317 May cause an allergic skin reaction H332 Harmful if inhaled H304 May be fatal if swallowed and enters airways H335 May cause respiratory irritation H410 Very toxic to aquatic life with long lasting effects |
| Precautionary statement(s) | |
| Prevention | P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection. P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. |
| Response | P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/… P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P312 Call a POISON CENTER/doctor/…if you feel unwell. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P332+P313 If skin irritation occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. P333+P313 If skin irritation or rash occurs: Get medical advice/attention. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P331 Do NOT induce vomiting. P391 Collect spillage. |
| Storage | P403+P235 Store in a well-ventilated place. Keep cool. P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed. |
| Disposal | P501 Dispose of contents/container to ... |
none
3.Composition/information on ingredients 3.1 Substances| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 1,3-dichloropropene | 1,3-dichloropropene | 542-75-6 | none | 100% |
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaledFresh air, rest. Refer for medical attention.
In case of skin contactWear protective gloves when administering first aid. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
In case of eye contactFirst rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
If swallowedRinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayedSYMPTOMS: Symptoms of exposure to this compound may include local irritation of the eyes skin and respiratory tract, dermatitis, gasping, coughing, substernal pain, extreme respiratory distress, lacrimation, central nervous system depression, acute gastrointestinal distress with pulmonary congestion and edema. It may also cause injury to the liver, kidneys and heart. ACUTE/CHRONIC HAZARDS: This compound is irritating to the skin, eyes and mucous membranes. It may also cause lacrimation. When heated to decomposition it emits toxic fumes.
VAPOR: Irritating to eyes, nose and throat. LIQUID: Will burn skin and eyes. Harmful if swallowed. (USCG, 1999)
4.3 Indication of immediate medical attention and special treatment needed, if necessaryIf this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. /Dichloropropenes/
5.Fire-fighting measures 5.1 Extinguishing media Suitable extinguishing mediaSuitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Specific hazards arising from the chemicalFlash point data for this chemical are not available, however literature indicates that this material is flammable.
FLAMMABLE. POISONOUS GASES ARE PRODUCED IN FIRE. Flashback along vapor trail may occur. Vapor may explode if ignited in an enclosed area. Toxic and irritating gases may be generated. (USCG, 1999)
5.3 Special protective actions for fire-fightersWear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures 6.1 Personal precautions, protective equipment and emergency proceduresUse personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautionsVentilation. Remove all ignition sources. Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable plastic containers as far as possible. Do NOT let this chemical enter the environment.
6.3 Methods and materials for containment and cleaning upACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.
7.Handling and storage 7.1 Precautions for safe handlingAvoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilitiesFireproof. Separated from metals and oxidants. Well closed. Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access.Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature 2 - 8°C.
8.Exposure controls/personal protection 8.1 Control parameters Occupational Exposure limit valuesNIOSH considers 1,3-dichloropropene to be a potential occupational carcinogen. NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concentration.
Recommended Exposure Limit: 10 Hour Time-Weighted Average: 1 ppm (5 mg/cu m), skin.
Biological limit valuesno data available
8.2 Appropriate engineering controlsHandle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE) Eye/face protectionSafety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protectionWear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protectionWear dust mask when handling large quantities.
Thermal hazardsno data available
9.Physical and chemical properties| Physical state | Linght yellow liquid |
|---|---|
| Colour | Colorless to straw-colored liquid |
| Odour | Pungent odor |
| Melting point/ freezing point | -60ºC |
| Boiling point or initial boiling point and boiling range | 108ºC |
| Flammability | Class IC Flammable Liquid: Fl.P. at or above 22.78°C and below 37.78°C.Flammable. Gives off irritating or toxic fumes (or gases) in a fire. |
| Lower and upper explosion limit / flammability limit | Lower flammable limit: 5.3% by volume; Upper flammable limit: 14.5% by volume |
| Flash point | 27ºC |
| Auto-ignition temperature | no data available |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | less than 1 mg/mL at 20.5°C |
| Partition coefficient n-octanol/water (log value) | log Kow = 2.06 (cis-isomer), 2.03 (trans-isomer) at 25°C |
| Vapour pressure | 34 mm Hg at 25°C |
| Density and/or relative density | 1.22 |
| Relative vapour density | 3.83 (Relative to Air) |
| Particle characteristics | no data available |
no data available
10.2 Chemical stabilityStable under recommended storage conditions.
10.3 Possibility of hazardous reactionsFlammable liquid.The vapour is heavier than air and may travel along the ground; distant ignition possible. As a result of flow, agitation, etc., electrostatic charges can be generated.TRANS-1,3-DICHLOROPROPENE reacts with aluminum, aluminum alloys, with other active metals and with some metal salts and halogens. Can react vigorously with oxidizing materials. .
10.4 Conditions to avoidno data available
10.5 Incompatible materialsIncompatible materials: Metals, strong oxidizing agents
10.6 Hazardous decomposition productsHazardous decomposition products formed under fire conditions - Carbon oxides, hydrogen chloride gas
11.Toxicological information Acute toxicity- Oral: LD50 Rat oral 140 + or - 25 mg/kg
- Inhalation: LC50 F333 rat (female) inhalation 904 ppm (4104 mg/cu m)/4 hr
- Dermal: no data available
no data available
Serious eye damage/irritationno data available
Respiratory or skin sensitizationno data available
Germ cell mutagenicityno data available
CarcinogenicityNTP: Reasonably anticipated to be a human carcinogen
Reproductive toxicityA study of male workers engaged in the manufacture of 1,3-dichloropropene indicated no significant effect on fertility at exposure levels occurring in the work environment. No evidence of developmental toxicity was observed in rats or rabbits exposed to 1,3-dichloropropene by inhalation, but significant maternal toxicity was seen in both species. In one study of rats exposed by inhalation, fewer fetuses per litter were reported at the highest exposure concentration but maternal toxicity was also observed. In other studies, no adverse reproductive effects were observed in rats and mice exposed by inhalation.
STOT-single exposureno data available
STOT-repeated exposureno data available
Aspiration hazardno data available
12.Ecological information 12.1 Toxicity- Toxicity to fish: LC50; Species: Pimephales promelas (Fathead minnow) weight 0.9 g; Conditions: static bioassay without aeration, 18°C, pH 7.2-7.5, water hardness 40-50 mg/L CaCO3, alkalinity 30-35 mg/L; Concentration: 4100 ug/L for 96 hr (95% confidence limit: 3390-4970 ug/L) /Technical material, 100%
- Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna (Water flea) 1st instar; Conditions: static bioassay without aeration, 21°C, pH 7.2-7.5, water hardness 40-50 mg/L CaCO3, alkalinity 30-35 mg/L; Concentration: 90 ug/L for 48 hr (95% confidence limit: 63-129 ug/L) /Technical material, 100%
- Toxicity to algae: EC50; Species: Anabaena flosaquae (Blue-Green Algae); Conditions: freshwater, static; Concentration: 108000 ug/L for 120 hr (95% confidence interval: 50000-232000 ug/L); Effect: decreased population abundance /96% purity
- Toxicity to microorganisms: no data available
AEROBIC: 1,3-Dichloropropene, present at 100 mg/L, reached 3% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test which classified the compound as not readily biodegradable(1); additional degradation was observed yielding 3-chloro-2-propen-1-ol(1), possibly from hydrolysis and degradation of the hydrolysis products(SRC). A BOD dilution water study using settled domestic wastewater as the microbia1 inoculum found that 5-10 mg/L concentrations of 1,3-dichloropropene were degraded by 54-85% after 7 days of incubation with the faster rates achieved following weekly adaptations(1); however, the rate of biodegradation for 1,3-dichloropropene in natural waters cannot be inferred from this screening study data(3). Common soil bacteria were able to utilize 1,3-dichloropropene as a sole carbon source in pure culture studies(4). Twelve weeks after labeled cis- or trans-1,3-dichloropropene was added to soil and stored in sealed containers, 19% of the cis and 18% of the trans isomers remained in sandy loam and 10% of cis and 22% of trans isomer remained in medium loam(5). After 20 weeks, 5% and 4% of the cis and trans isomer, respectively, remained in sandy loam and 3% and 14%, respectively remained in the medium loam(5); the half-life of the applied dichloropropenes were 3-4 weeks; it was possible that some of the parent compound was lost by volatilization(5). 14C-1,3-Dichloropropene, added at 100 ug/g soil and incubated aerobically in the dark at 25°C, displayed half-lives of 1.8, 12.3, and 61 days using Wahiawa silt clay, Catlin silt loam, and Fuquay loamy sand, respectively(6); degradation products were 3-chloroallyl alcohol, 3-chloroacrylic acid, numerous minor carboxylic acid metabolites, and carbon dioxide(6). Degradation of 1,3-dichloropropene was greatly enhanced in amended soils compared to the unamended soil, and the degree of acceleration varied with the type as well as the rate of amendment(7); compost manure was more effective in stimulating 1,3-dichloropropene degradation than a less decomposed biosolid-manure mix; the acceleration in compost manure-amended soils was a combined result of enhanced chemical and microbial degradation, since sterilization only partially reduced the enhanced degradation(7). Complete mineralization of 1,3-dichloropropene, based on chloride release, can be a matter of years(8). A 5 ug/mL test compound added to a sediment sample from a drainage ditch at an agricultural field station in Marcham, England was readily converted to 3-chloropropionic acid(9). 1,3-Dichloropropene is degraded more rapidly in soil that has a history of treatment with this pesticide than in previously untreated soil(3). While the degradation rates of the cis- and trans- isomers are similar in untreated soil, degradation in previously treated soil has been shown to be more rapid for trans-1,3-dichloropropene than for cis-1,3-dichloropropene(3).
12.3 Bioaccumulative potentialAn estimated BCF of 10 was calculated in fish for 1,3-dichloropropene(SRC), using a log Kow of 2.04 (average for the cis- and trans-isomers)(1) and a regression-derived equation(2). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soilMeasured Koc values of 23 and 26 for the cis- and trans- isomers of 1,3-dichloropropene, respectively, have been reported(1). The average Koc for 3 soils with organic carbon of 3.19%, 10.4%, and 55.1% was 27 and 28 for cis- and trans-1,3-dichloropropene, respectively(2). The average maximum Koc values were 20 for sand, 25 for loamy sand, and 41 and 42 for two clay soils(3). According to a classification scheme(4), these Koc values suggest that 1,3-dichloropropene is expected to have very high mobility in soil. The adsorption onto soil from the vapor is greater for the trans- than the cis- isomer(3). The adsorption isotherm for the vapor/soil system is linear(3). When 1,3-dichloropropene is used in farm fields, it is sprayed directly on the ground or injected into the soil(5). Once in the soil, it can exist as a gas or dissolved in water. 1,3-Dichloropropene can adsorb more strongly to soil when it is in the vapor phase than when it is dissolved in water(5). Vapor-phase adsorption can be approximately 3-times greater at 2°C than it is at 20°C, and adsorption isotherms measured for humus sand, peaty sand, and peat indicate vapor-phase Koc values ranging from 450 to 750(5). According to a classification scheme(4), these vapor-phase Koc values suggest that 1,3-dichloropropene may have moderate to low mobility in soil.
12.5 Other adverse effectsno data available
13.Disposal considerations 13.1 Disposal methods ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packagingContainers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information 14.1 UN Number| ADR/RID: UN2047 | IMDG: UN2047 | IATA: UN2047 |
| ADR/RID: DICHLOROPROPENES |
| IMDG: DICHLOROPROPENES |
| IATA: DICHLOROPROPENES |
| ADR/RID: 3 | IMDG: 3 | IATA: 3 |
| ADR/RID: III | IMDG: III | IATA: III |
| ADR/RID: yes | IMDG: yes | IATA: yes |
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Codeno data available
15.Regulatory information 15.1 Safety, health and environmental regulations specific for the product in question| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| 1,3-dichloropropene | 1,3-dichloropropene | 542-75-6 | none |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Not Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Creation Date | Aug 18, 2017 |
|---|---|
| Revision Date | Aug 18, 2017 |
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
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