| Product name | coumaphos |
|---|
| Product number | - |
|---|---|
| Other names | Agridip |
| Identified uses | For industry use only. Insecticide |
|---|---|
| Uses advised against | no data available |
| Company | MOLBASE (Shanghai) Biotechnology Co., Ltd. |
|---|---|
| Address | Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, Xuhui District, Shanghai, China |
| Telephone | +86(21)64956998 |
| Fax | +86(21)54365166 |
| Emergency phone number | +86-400-6021-666 |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
Acute toxicity - Oral, Category 2
Acute toxicity - Dermal, Category 4
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
2.2 GHS label elements, including precautionary statements| Pictogram(s) |   |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H300 Fatal if swallowed H312 Harmful in contact with skin H410 Very toxic to aquatic life with long lasting effects |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P273 Avoid release to the environment. |
| Response | P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/… P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P312 Call a POISON CENTER/doctor/…if you feel unwell. P362+P364 Take off contaminated clothing and wash it before reuse. P391 Collect spillage. |
| Storage | P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to ... |
none
3.Composition/information on ingredients 3.1 Substances| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| coumaphos | coumaphos | 56-72-4 | none | 100% |
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaledFresh air, rest. Artificial respiration may be needed. No mouth-to-mouth artificial respiration. Refer immediately for medical attention.
In case of skin contactRemove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . See Notes.
In case of eye contactFirst rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
If swallowedRinse mouth. Give a slurry of activated charcoal in water to drink. NO mouth-to-mouth artificial respiration. Refer immediately for medical attention.
4.2 Most important symptoms/effects, acute and delayedVery toxic, probable oral lethal dose is 50-500 mg/kg, or between 1 teaspoonful and 1 oz. for a 70 kg (150 lb.) person. May be fatal if inhaled, swallowed, or absorbed through skin. Contact may cause burns to skin and eyes. (EPA, 1998)
4.3 Indication of immediate medical attention and special treatment needed, if necessaryA 32 yr old male with acute coumaphos poisoning ... the organophosphate poisoning was successfully managed by artificial ventilation, an infusion of pralidoxime and intermittent atropine. ...[Moore PG, James OF; Postgrad Med J 57 (672): 660-62 (1981)] Full text: PMC2426093
5.Fire-fighting measures 5.1 Extinguishing media Suitable extinguishing mediaExtinguish with water, foam, carbon dioxide, or dry chemical.
5.2 Specific hazards arising from the chemicalWhen heated to decomposition, it emits very toxic fumes of sulfur oxides, phosphorus oxides, and chlorides. Incompatible with piperonyl butoxide. Stable in water. (EPA, 1998)
5.3 Special protective actions for fire-fightersWear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures 6.1 Personal precautions, protective equipment and emergency proceduresUse personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautionsPersonal protection: particulate filter respirator adapted to the airborne concentration of the substance and protective clothing. Do NOT wash away into sewer. Collect the spilled substance into containers. If appropriate, moisten first to prevent dusting. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning upHydrolysis: This cmpd can be decomposed on heating with concentrated alkali. It is oxidized with nitric acid or other oxidizing agents to the phosphate analogue, coroxon. Dilute alkali (pH 8-12) causes an opening of the pyrone ring, which can be closed again by acidification to yield the original compound.
7.Handling and storage 7.1 Precautions for safe handlingAvoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilitiesSeparated from food and feedstuffs. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access.Storage temperature: Ambient
8.Exposure controls/personal protection 8.1 Control parameters Occupational Exposure limit valuesno data available
Biological limit valuesno data available
8.2 Appropriate engineering controlsHandle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE) Eye/face protectionSafety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protectionWear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protectionWear dust mask when handling large quantities.
Thermal hazardsno data available
9.Physical and chemical properties| Physical state | tan or beige solid |
|---|---|
| Colour | Colorless crystals |
| Odour | Slight sulfur-like odor |
| Melting point/ freezing point | 91ºC |
| Boiling point or initial boiling point and boiling range | 449.9ºC at 760 mmHg |
| Flammability | Not combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire. Heating will cause rise in pressure with risk of bursting. |
| Lower and upper explosion limit / flammability limit | no data available |
| Flash point | 225.9ºC |
| Auto-ignition temperature | no data available |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | less than 1 mg/mL at 22.22°C |
| Partition coefficient n-octanol/water (log value) | log Kow = 4.13 |
| Vapour pressure | 1e-07 mm Hg at 20°C (EPA, 1998) |
| Density and/or relative density | 1.38 g/cm3 |
| Relative vapour density | no data available |
| Particle characteristics | no data available |
no data available
10.2 Chemical stabilityStable under recommended storage conditions.
10.3 Possibility of hazardous reactionsIt is combustible ...Organothiophosphates, such as COUMAPHOS, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. It reacts with strong oxidizing agents and alkaline materials.
10.4 Conditions to avoidno data available
10.5 Incompatible materialsStrong oxidizing agents
10.6 Hazardous decomposition productsToxic & irritating oxides of sulfur & phosphorus may form in fire.
11.Toxicological information Acute toxicity- Oral: LD50 Rabbit oral 80 mg/kg
- Inhalation: no data available
- Dermal: no data available
no data available
Serious eye damage/irritationno data available
Respiratory or skin sensitizationno data available
Germ cell mutagenicityno data available
CarcinogenicityCancer Classification: Not Likely to be Carcinogenic to Humans
Reproductive toxicityno data available
STOT-single exposureno data available
STOT-repeated exposureno data available
Aspiration hazardno data available
12.Ecological information 12.1 Toxicity- Toxicity to fish: LC50; Species: Salvelinus namaycush (lake trout) weight 2.1 g; Conditions: static lab bioassay, 12°C; Concentration: 593 ug/L for 96 hr (95% confidence limit: 416-846 ug/L) /Technical material, 95-97%
- Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna /(Water flea)/; Concentration: 1.0 ug/L for 48 hr /Conditions of bioassay not specified
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
AEROBIC: In a biodegradability screening test using an activated sludge inoculum and 50 ug/L of radio-labeled test compound, only 0.9% of coumaphos was mineralized in 5 days(1). Coumaphos in dipping solutions can be effectively biodegraded by specially grown pure cultures(2). Degradation was slow in a sandy loam soil, half-life approximately 300 days(2). The half-life in a field test in which 300 ppm of coumaphos was incorporated into the upper 15 cm of silty loam soil was about 200 days(2). The major degradation products were chlorferon (3-chloro-4-methyl-7-hydroxycoumarin) and the oxygen analog(2). No degradation was noted in a microbially-active Drummer silty clay loam soil in 22 days(2). Coumaphos was degraded in 7 days in soil slurries using soil from six vat waste disposal pits in Texas(4). In similar experiments using (14)C ring-labeled coumaphos, 61% of the (14)C was recovered as (14)CO2 when radiolabeled coumaphos was added to soil slurries containing 1200 mg/L coumaphos; no loss of coumaphos nor production of (14)CO2 was observed when sodium azide was added to the soil slurries(3).
12.3 Bioaccumulative potentialA BCF of 110 was determined in Golden ide (Leuciscus idus melanotus) in a 3-day test(1). A BCF of 540 was determined in bluegill (Lepomis macrochirus) exposed for 28 days(2). According to a classification scheme(3), these BCFs suggest bioconcentration in aquatic organisms is high. The 24 hr bioaccumulation factor in algae (Chlorella fusca) is 470(1).
12.4 Mobility in soilKoc values of 5778 to 21,120 were reported in 4 soil types(1). According to a classification scheme(2), this Koc value range suggests that coumaphos is expected to be immobile in soil.
12.5 Other adverse effectsno data available
13.Disposal considerations 13.1 Disposal methods ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packagingContainers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information 14.1 UN Number| ADR/RID: UN2811 | IMDG: UN2811 | IATA: UN2811 |
| ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. |
| IMDG: TOXIC SOLID, ORGANIC, N.O.S. |
| IATA: TOXIC SOLID, ORGANIC, N.O.S. |
| ADR/RID: 6.1(a) | IMDG: 6.1(a) | IATA: 6.1(a) |
| ADR/RID: II | IMDG: II | IATA: II |
| ADR/RID: yes | IMDG: yes | IATA: yes |
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Codeno data available
15.Regulatory information 15.1 Safety, health and environmental regulations specific for the product in question| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| coumaphos | coumaphos | 56-72-4 | none |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Not Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Creation Date | Aug 17, 2017 |
|---|---|
| Revision Date | Aug 17, 2017 |
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
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