首页 > 化工百科 > 其他 > 化学试剂 > 芳香化合物 > L-5-甲基四氢叶酸钙
151533-22-1 L-5-甲基四氢叶酸钙

L-5-甲基四氢叶酸钙

英文名称:Levomefolate calcium
CAS:

151533-22-1

分子式:C20H23CaN7O6
精选商品
  • 化合物简介
  • 基本信息
  • 编号系统
  • 物化性质
  • MSDS
  • 图谱

L-5-甲基四氢叶酸钙简介

Levomefolic acid (INN) (also known as L-5-MTHF, L-methylfolate and L-5-methyltetrahydrofolate and (6S)-5-methyltetrahydrofolate, and (6S)-5-MTHF) is the primary biologically active form of folate used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine. It is also the form found in circulation and transported across membranes into tissues and across the blood-brain barrier. In the cell, L-methylfolate is used in the methylation of homocysteine to form methionine and tetrahydrofolate (THF). THF is the immediate acceptor of one carbon units for the synthesis of thymidine-DNA, purines (RNA and DNA) and methionine. The un-methylated form, folic acid (vitamin B9), is a synthetic form of folate, and must undergo enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR) to become biologically active.
It is synthesized in the absorptive cells of the small intestine from polyglutamylated dietary folate. It is a methylated derivative of tetrahydrofolate. Levomefolic acid is generated by MTHFR from 5,10-methylenetetrahydrofolate (MTHF) and used to recycle homocysteine back to methionine by 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) also known as methionine synthase (MS).
L-methylfolate is water-soluble and primarily excreted via the kidneys. In a study of 21 subjects with coronary artery disease, peak plasma levels were reached in one to three hours following oral or parenteral administration. Peak concentrations were found to be more than seven times higher than folic acid (129 ng/ml vs. 14.1 ng/ml).
Levomefolic acid (and folic acid in turn) has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers. It bypasses several metabolic steps in the body and better binds thymidylate synthase with fDump, a metabolite of the drug fluorouracil.
Levomefolate calcium, a calcium salt of levomefolic acid, developed and produced by Merck KGaA, is sold under the brand names Metafolin (a registered trademark of Merck KGaA) and incorporated in Deplin (trademark of Pamlab, LLC).

L-5-甲基四氢叶酸钙基本信息

中文名称 L-5-甲基四氢叶酸钙 英文名称 Levomefolate calcium
中文别名

L-甲基叶酸盐;

查看更多中文别名
英文别名

Nutrifolin; Bodyfolin; L-5-MTHF-Ca; L-5-Methyltetrahydrofolate calcium; L-5-Methyletrahydrofolate calciuM; Calcium levomefolate; LMCA; CALCIUML-5-METHYLTETRAHYDROFOLATE;

查看更多英文别名
CAS号 151533-22-1 分子式 C20H23CaN7O6
分子量 497.51800 精确质量 497.13400
PSA 208.43000 LOGP -1.67900

L-5-甲基四氢叶酸钙编号系统

UNII A9R10K3F2F

L-5-甲基四氢叶酸钙物化性质

外观与性状:
灰白色至淡黄色固体
熔点:
>300ºC
SDS 1.0 中文 展开
SDS 1.0 英文 展开
1H NMR : Predict展开

核磁图谱 1H NMR : Predict

收起
查看更多
L-5-甲基四氢叶酸钙
CAS号:151533-22-1 分子式:C20H23CaN7O6 分子量:497.51800

化工圈APP

二维码

微信公众号

二维码

购物车

不要让您的购物车空着哦,买试剂买原料
如果您已添加过宝贝,那就赶紧登录查看吧

投诉建议

  • 咨询类别
  • 问题描述
  • 联系人电话
  • 联系人