107724-20-9 依普利酮

依普利酮

英文名称:eplerenone
CAS:

107724-20-9

分子式:C24H30O6
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  • 化合物简介
  • 基本信息
  • 编号系统
  • 物化性质
  • 生产方法及用途
  • 合成路线
  • MSDS
  • 图谱
  • 上游原料

依普利酮简介

Eplerenone (INN) is a steroidal antimineralocorticoid of the spirolactone group that is used as an adjunct in the management of chronic heart failure. It is similar to the diuretic spironolactone, though it is much more selective for the mineralocorticoid receptor in comparison (i.e., does not possess any antiandrogen, progestogen, glucocorticoid, or estrogenic effects), and is specifically marketed for reducing cardiovascular risk in patients following myocardial infarction. By modifying the alternative drug Spironolactone, the new drug was developed in part to avoid undesired androgenic side effects in male patients. Eplerenone is a potassium-sparing diuretic, meaning that it helps the body get rid of water but still keep potassium.
Eplerenone was developed by Pharmacia Corporation, which was acquired by Pfizer in 2002. It was marketed by Pfizer under the trade name Inspra. The US Food and Drug Administration (FDA) approved the drug for sale in the United States in 2002. Eplerenone is currently approved for sale in the US, EU, Netherlands and Japan. Relative to dosage, eplerenone costs an estimated $2.93 per day when treating congestive heart failure and $5.86 per day when treating hypertension.

依普利酮基本信息

中文名称 依普利酮 英文名称 eplerenone
中文别名

9,11α-乙氧基-17-羟基-3-氧-17α-孕-4-烯-7α,21-二羧酸-γ-内甲酯; 伊普利酮;

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英文别名

epoxymexrenone; Inspra; EplerenoneC24H3006; Elperenone; Epleremone; EPLERENONE; 9,11α-Epoxy-17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic Acid γ-Lactone Methyl Ester; EPLERINONE;

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CAS号 107724-20-9 分子式 C24H30O6
分子量 414.49100 精确质量 414.20400
PSA 82.20000 LOGP 3.12450

依普利酮编号系统

UNII 6995V82D0B

依普利酮物化性质

外观与性状:
白色固体
密度:
1.31g/cm3
沸点:
597.9ºC at 760mmHg
熔点:
241-243ºC
闪点:
259.5ºC
折射率:
1.587
蒸汽压:
0mmHg at 25°C

生产方法及用途

用途

具有对醛固酮受体选择性强、降压效果好,作用持久等特点,并可逆转或减轻醛固酮对心血管的许多不利影响。

SDS 1.0 中文 展开
SDS 1.0 英文 展开
MSDS 中文 展开
1H NMR : Predict展开

核磁图谱 1H NMR : Predict

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依普利酮
CAS号:107724-20-9 分子式:C24H30O6 分子量:414.49100

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