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140111-52-0 (±)-三色素蛙素

(±)-三色素蛙素

英文名称:(±)-Epibatidine,(±)-exo-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1.]heptane
CAS:

140111-52-0

分子式:C11H13ClN2
  • 化合物简介
  • 基本信息
  • 编号系统
  • 物化性质
  • 合成路线
  • MSDS
  • 图谱
  • 上游原料

(±)-三色素蛙素简介

Epibatidine is an alkaloid that is secreted by the Ecuadoran frog Epipedobates anthonyi. It was discovered by John W. Daly in 1974, but its structure was not fully elucidated until 1992.
Epibatidine is toxic. Its toxicity stems from its ability to interact with nicotinic and muscarinic acetylcholine receptors. These receptors are involved in the transmission of painful sensations, and in movement, among other functions. Epibatidine then causes numbness and eventually paralysis. Doses are lethal when the paralysis causes respiratory arrest. Originally, it was thought that epibatidine could be useful as a drug. However, because it can be deadly even at very low doses, it is no longer being researched for potential therapeutic uses.

(±)-三色素蛙素基本信息

中文名称 (±)-三色素蛙素 英文名称 (±)-Epibatidine,(±)-exo-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1.]heptane
中文别名

(+/-)-地棘蛙素;

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英文别名

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CAS号 140111-52-0 分子式 C11H13ClN2
分子量 208.68700 精确质量 208.07700
PSA 24.92000 LOGP 2.67170

(±)-三色素蛙素编号系统

UNII M6K314F1XX

(±)-三色素蛙素物化性质

密度:
1.223g/cm3
沸点:
336.7ºC at 760mmHg
闪点:
157.4ºC
折射率:
1.576
蒸汽压:
0.00011mmHg at 25°C
SDS 1.0 中文 展开
SDS 1.0 英文 展开
1H NMR : Predict展开

核磁图谱 1H NMR : Predict

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上游原料
(+)-N-(Trifluoroacetyl)epibatidine 6-氯烟酸 (1S,2R,4S)-methanesulfonic acid 4-(N,N-bis(tert-butoxycarbonyl)amino)-2-(6-chloropyridin-3-yl)cyclohexyl ester (-)-(1S,4R,4aS,5S,8aS)-5-acetoxy-1,4,4a,8a-tetrahydro-endo-1,4-methanonaphthalen-8(5H)-one (1S,2R,4S)-4-(N,N-bis(tert-butoxycarbonyl)amino)-2-(6-chloropyridin-3-yl)cyclohexanol N-benzyl-N-(cyclohex-3-en-1-yl)-2,2,2-trifluoroacetamide 2-氯-5-羟甲基吡啶 (5S,1R,3R,4R)-3-aza-4-(triethylsilyloxy)-6-(6-chloro(3-pyridyl))-5-(methoxycarbonyl)bicyclo[2.2.2]oct-2-en-2-yl (tert-butoxy)formate (+)-(1S,4R,4aS,5R,8S,8aR)-5-Acetoxy-1,4,4a,5,8,8a-hexahydro-8-hydroxy-endo-1,4-methanonaphthalene (2S,1R)-2-(6-chloro(3-pyridyl))-4-oxocyclohexanecarboxamide (4R)-3-{[(2S,1R,3R,4R)-6-aza-1-(triethylsilyloxy)-3-(6-chloro(3-pyridyl))-5-oxobicyclo[2.2.2]oct-2-yl]carbonyl}-4-benzyl-1,3-oxazolidin-2-one (1R,2S,4S)-2-((S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionyloxy)-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester N-[(2R,1R)-2-(6-chloro(3-pyridyl))-4-oxocyclohexyl](tert-butoxy)carboxamide methyl (2S,1R,3R,4R)-6-aza-1-(triethylsilyloxy)-3-(6-chloro(3-pyridyl))-5-oxobicyclo[2.2.2]octane-2-carboxylate (2S,1R)-2-(6-chloro(3-pyridyl))-4-oxocyclohexanecarbonitrile (1S,2R,5S)-5-methyl-2-(2-(naphthalen-2-yl)propan-2-yl)cyclohexyl (1S,4R)-5-(6-chloropyridin-3-yl)-2-oxa-3-azabicyclo[2.2.2]oct-5-ene-3-carboxylate (1R,4S)-2-氧代-7-氮杂双环[2.2.1]庚烷-7-羧酸叔丁酯 6-氯烟醛 2-chloro-5-(1,5-cyclohexadienyl)pyridine 2-氯-5-碘吡啶 5-溴-2-氯吡啶 3-[(2E)-3-(6-chloro(3-pyridyl))prop-2-enoyl](4R)-4-benzyl-1,3-oxazolidin-2-one 4-N-Boc-氨基环己酮 4-(N,N-bis(tert-butoxycarbonyl)amino)cyclohexanone (2R,4S)-4-(N,N-bis(tert-butoxycarbonyl)amino)-2-(6-chloropyridin-3-yl)cyclohexanone N-cyclohex-3-en-1-yl-2,2,2-trifluoroacetamide (-)-exo-7-[(1,1-Domethylethoxy)carbonyl]-7-azabicyclo[2.2.1]heptan-2-ol (-)-tert-butyl N-[(1R,2R,4S)-2-(6-chloropyridin-3-yl)-4-hydroxycyclohexyl]carbamate N-[(1R,2R,4R)-4-bromo-2-(6-chloro(3-pyridyl))cyclohexyl](tert-butoxy)carboxamide
(±)-三色素蛙素
CAS号:140111-52-0 分子式:C11H13ClN2 分子量:208.68700

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