首页 > 化工百科 > 其他 > 化学试剂 > 卤化物 > (8R)-8-乙基-4-甲基-2-(2,3,5-三氯苯基)-1,4,7,8-四氢-5H-咪唑并[2,1-I]嘌呤-5-酮盐酸盐(1:1)
591771-91-4 (8R)-8-乙基-4-甲基-2-(2,3,5-三氯苯基)-1,4,7,8-四氢-5H-咪唑并[2,1-I]嘌呤-5-酮盐酸盐(1:1)

(8R)-8-乙基-4-甲基-2-(2,3,5-三氯苯基)-1,4,7,8-四氢-5H-咪唑并[2,1-I]嘌呤-5-酮盐酸盐(1:1)

英文名称:PSB 10 hydrochloride,8-Ethyl-1,4,7,8-tetrahydro-4-methyl-2-(2,3,5-trichlorophenyl)-5H-imidazo[2,1-i]purin-5-onemonohydrochloride
CAS:

591771-91-4

分子式:C16H15Cl4N5O
  • 化合物简介
  • 基本信息
  • 物化性质
  • MSDS
  • 图谱

(8R)-8-乙基-4-甲基-2-(2,3,5-...简介

PSB-10 is a drug which acts as a selective antagonist for the adenosine A3 receptor (ki value at human A3 receptor is 0.44 nM), with high selectivity over the other three adenosine receptor subtypes (ki values at human A1, A2A and A2B receptors are 4.1, 3.3 and 30 µM). Further pharmacological experiments in a [35S]GTPγS binding assay using hA3-CHO-cells indicated that PSB-10 acts as an inverse agonist (IC50 = 4 nM). It has been shown to produce antiinflammatory effects in animal studies. Simple xanthine derivatives such as caffeine and DPCPX have generally low affinity for the A3 subtype and must be extended by expanding the ring system and adding an aromatic group to give high A3 affinity and selectivity. The affinity towards adenosine A3 subtype was measured against the radioligand PSB-11.

(8R)-8-乙基-4-甲基-2-(2,3,5-...基本信息

中文名称 (8R)-8-乙基-4-甲基-2-(2,3,5-三氯苯基)-1,4,7,8-四氢-5H-咪唑并[2,1-I]嘌呤-5-酮盐酸盐(1:1) 英文名称 PSB 10 hydrochloride,8-Ethyl-1,4,7,8-tetrahydro-4-methyl-2-(2,3,5-trichlorophenyl)-5H-imidazo[2,1-i]purin-5-onemonohydrochloride
中文别名

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英文别名

PSB 10 HYDROCHLORIDE;

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CAS号 591771-91-4 分子式 C16H15Cl4N5O
分子量 435.13500 精确质量 433.00300
PSA 67.97000 LOGP 3.62080

(8R)-8-乙基-4-甲基-2-(2,3,5-...物化性质

储存条件:
Desiccate at +4ºC
SDS 1.0 中文 展开
SDS 1.0 英文 展开
1H NMR : Predict展开

核磁图谱 1H NMR : Predict

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(8R)-8-乙基-4-甲基-2-(2,3,5-三氯苯基)-1,4,7,8-四氢-5H-咪唑并[2,1-I]嘌呤-5-酮盐酸盐(1:1)
CAS号:591771-91-4 分子式:C16H15Cl4N5O 分子量:435.13500

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