133343-34-7 乳胞素

乳胞素

英文名称:lactacystin
CAS:

133343-34-7

分子式:C15H24N2O7S
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  • 化合物简介
  • 基本信息
  • 编号系统
  • 物化性质
  • MSDS
  • 图谱

乳胞素简介

Lactacystin is an organic compound naturally synthesized by bacteria of the genus Streptomyces first described in 1991. The first total synthesis of lactacystin was developed by Elias Corey in 1992. Lactacystin binds and inhibits specific catalytic subunits of the proteasome, a protein complex responsible for the bulk of proteolysis in the cell, as well as proteolytic activation of certain protein substrates. It was the first non-peptidic proteasome inhibitor discovered and is widely used as a research tool in biochemistry and cell biology. It covalently modifies the amino-terminal threonine of specific catalytic subunits of the proteasome, a discovery helped to establish the proteasome as a mechanistically novel class of protease: an amino-terminal threonine protease. The molecule is most commonly used as in biochemistry and cell biology laboratories as a selective inhibitor of the proteasome. The molecule is a lactam, or cyclic amide. A number of syntheses of this molecule have been published and there are more than 1,500 citations for lactacystin in PubMed as of 2013.

乳胞素基本信息

中文名称 乳胞素 英文名称 lactacystin
中文别名

S-[2R,3S,4R]-3-HYDROXY-2-[(1S)-1-HYDROXY-2-METHYLPROPYL]-4-METHYL-5-OXO-2-PYROLIDINECARBONYL;

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英文别名

(+)-Lactacystin; Lactacystin;

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CAS号 133343-34-7 分子式 C15H24N2O7S
分子量 376.42500 精确质量 376.13000
PSA 178.33000 LOGP -0.56230

乳胞素编号系统

MDL号 MFCD01076525
PubChem号 24896445

乳胞素物化性质

外观与性状:
白色至灰白色粉末
密度:
1.367 g/cm3
沸点:
714.9ºC at 760 mmHg
熔点:
233-235ºC dec.
闪点:
386.1ºC
折射率:
1.559
储存条件:
-20ºC
蒸汽压:
1.31E-23mmHg at 25°C
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核磁图谱 Predict 1H proton NMR

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乳胞素
CAS号:133343-34-7 分子式:C15H24N2O7S 分子量:376.42500

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