N-亚硝基二正丁胺

Acute toxicity - Oral, Category 4

Carcinogenicity, Category 2

Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed H351 Suspected of causing cancer
Precautionary statement(s)
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P280 Wear protective gloves/protective clothing/eye protection/face protection.
Response	P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell. P330 Rinse mouth. P308+P313 IF exposed or concerned: Get medical advice/ attention.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to ...

none

Consult a physician. Show this safety data sheet to the doctor in attendance.

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

Wash off with soap and plenty of water. Consult a physician.

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: Inhalation of material may be harmful. Contact may cause burns to skin and eyes. Inhalation of Asbestos dust may have a damaging effect on the lungs. Fire may produce irritating, corrosive and/or toxic gases. Some liquids produce vapors that may cause dizziness or suffocation. Runoff from fire control may cause pollution. (ERG, 2016)

...After oral administration of NDBA; in guinea pigs, glucuronide of N-nitroso-n-butyl-n-(3-hydroxybutyl)amine and traces of N-nitroso-n-butyl-n-(2-hydroxy-3-carboxypropyl)amine were... excreted.

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: SMALL FIRE: Dry chemical, CO2, water spray or regular foam. LARGE FIRE: Water spray, fog or regular foam. Do not scatter spilled material with high-pressure water streams. Move containers from fire area if you can do it without risk. Dike fire-control water for later disposal. FIRE INVOLVING TANKS: Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. (ERG, 2016)

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: Some may burn but none ignite readily. Containers may explode when heated. Some may be transported hot. For UN3508, be aware of possible short circuiting as this product is transported in a charged state. (ERG, 2016)

Wear self-contained breathing apparatus for firefighting if necessary.

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms. ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal. ... The plastic bag should be sealed immediately. ... The sealed bag should be labelled properly. ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated. ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practicable to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired. ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/

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Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Wear dust mask when handling large quantities.

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Stable at room temperature for more than 14 days in neutral or alkaline aqueous solutions in dark, slightly less stable in acidic solutions; light-sensitive, especially to UV light.

N-NITROSODI-N-BUTYLAMINE is a nitrated azo derivative. Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides.

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Strong oxidants (peracids) oxidize it to corresponding nitramine; can be reduced to corresponding hydrazine and or amine.

When heated to decomposition it emits toxic fumes of /nitrogen oxide/.

• Oral: LD50 Hamster oral 2150 mg/kg
• Inhalation: no data available
• Dermal: no data available

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CLASSIFICATION: B2; probable human carcinogen. BASIS FOR CLASSIFICATION: Increased incidences of several tumor types in rats, mice and hamsters exposed by various routes.

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• Toxicity to fish: no data available
• Toxicity to daphnia and other aquatic invertebrates: no data available
• Toxicity to algae: no data available
• Toxicity to microorganisms: no data available

AEROBIC: Biodegradation data for N,N-dibutylnitrosoamine were not located(SRC, 2005), however data were available for the structurally similar compounds N-nitrosodi-n-propylamine and N-nitrosodiethylamine. In one study, settled domestic wastewater was used as the inoculum for static biodegradation tests on N-nitrosodi-n-propylamine(1). The biodegradation after 7 days incubation each in the original culture and the first, second, and third subcultures at an initial N-nitrosodi-n-propylamine concentration of 5 mg/l was 27%, 37%, 47%, and 50%, respectively(1). At an initial concentration of 10 mg/L, the degradation was 0%, 8%, 40%, and 40%, respectively(1). In municipal activated sludge treatment plants, N-nitrosodi-n-propylamine influent concentrations of 0.5 and 6.7 ug/L were reduced by 88 and 99%, respectively(2). However, 0% removal of N-nitroso-n-propylamine was reported at two industrial activated sludge treatment plants with an average N-nitrosodi-n-propylamine influent concentration of 11 mgL(2). No biodegradation of N-nitrosodi-n-propylamine occurred in die-away tests in Cayuga Lake water (New York) over a period of 3.5 months, and a lag of nearly 30 days was observed before its slow disappearance from soil(3). N-Nitrosodi-n-propylamine's half-life in aerobic soils under laboratory conditions was about 3 weeks with volatilization and biodegradation being the primary removal processes(4). N-Nitrosodiethylamine, at 18.0 ppm in lake water, was essentially unchanged after 108 days incubation in the dark at 30°C(3). While the level of N-nitrosodiethylamine amended with raw sewage at pH 6.0 slowly decreased from approximately 17 ppm to 12 ppm over 14 days, the fact that the decrease was nearly the same in sterilized samples indicates that abiotic factors may have been responsible for the loss(3). N-Nitrosodiethylamine has been shown to slowly degrade in soil after a lag period. In one study, 50% of 14C-N-nitrosodiethylamine was mineralized from Matapeake loam soil in over a week at 30°C(4). Based on the data for these structurally similar compounds, biodegradation may be an important fate process for N,N-dibutylnitrosoamine in the environment.

An estimated BCF of 59 was calculated for N,N-dibutylnitrosoamine(SRC), using a log Kow of 2.63(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC), provided the compound is not altered physically or chemically once released into the environment.

The Koc of N,N-dibutylnitrosoamine is estimated as 642(SRC), using a log Kow of 2.63(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that N,N-dibutylnitrosoamine is expected to have low mobility in soil.

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The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

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• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/