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68497-62-1 普拉西坦水合物

普拉西坦水合物

英文名称:Pramiracetam Hydrate
CAS:

68497-62-1

分子式:C14H27N3O2
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  • 化合物简介
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  • 物化性质
  • 安全信息
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  • 上游原料

普拉西坦水合物简介

Pramiracetam is a central nervous system stimulant and nootropic agent belonging to the racetam family of drugs. It is marketed by Menarini under the brand name Pramistar as a treatment for memory and attention deficits in aging people with neurodegenerative and vascular dementias in Italy and some Eastern European countries.
Pramiracetam was discovered by scientists at Parke-Davis, at that time a division of Warner-Lambert, in the late 1970s; patents expired in 1996. Warner-Lambert conducted clinical trials in Alzheimer's Disease and abandoned that indication after Phase II trials showed mixed results; it then began to develop it as an orphan drug as an adjunct to electroconvulsive therapy for major depressive disorder, in part to take advantage of the administrative exclusivity provided by the orphan status. It licensed European rights to Menarini which continued developing it for dementias, and in 1991 it licensed US and other non-European rights to Cambridge Neuroscience, Inc, (CNI) which pursued the ECT indication, as well as a use in restoring cognitive function after stroke or traumatic brain injury. CNI obtained the orphan designation for the ECT use from the FDA in 1991, which was later withdrawn when CNI abandoned the drug.
CNI conducted a clinical trial in 4 people who had cognitive problems following a head injury. Trials conducted by or on behalf of Menarini and Warner-Lambert included two small trials conducted in the Ukraine, one in people with cerebrovascular disease and another in people with concussion. Another small trial was performed in Italy, on healthy people in whom amnesia was induced with scopolamine.

普拉西坦水合物基本信息

中文名称 普拉西坦水合物 英文名称 Pramiracetam Hydrate
中文别名

普拉西坦;

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英文别名

N-[2-[di(propan-2-yl)amino]ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide;

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CAS号 68497-62-1 分子式 C14H27N3O2
分子量 269.38300 精确质量 269.21000
PSA 52.65000 LOGP 1.17260

普拉西坦水合物编号系统

UNII 4449F8I3LE

普拉西坦水合物物化性质

外观与性状:
白色结晶粉末
密度:
1.036 g/cm3
沸点:
461ºC at 760 mmHg
闪点:
232.6ºC
折射率:
1.495

安全信息

海关编码:
2942000000
信号词:
Warning
危险标志:
GHS07
危险性描述:
H302

生产方法及用途

用途

本品为吡拉西坦的类似物,新的吡咯烷酮类脑功能改善剂,适用于记忆及识别功能减退、语言障碍。

SDS 1.0 中文 展开
SDS 1.0 英文 展开
MSDS 中文 展开
1H NMR : Predict展开

核磁图谱 1H NMR : Predict

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国家名称 海关编码 海关数据更新时间 操作
中国 2933790090 2019-03 申报要素
美国 2933798500 2019-03 概述
印度 29337900 2019-03 概述
欧盟 29337900 2019-03 概述
英国 2933790090 2019-03 概述
日本 293379000 2019-03 概述
韩国 2933799000 2019-03 概述
加拿大 2933790000 2019-03 概述
普拉西坦水合物
CAS号:68497-62-1 分子式:C14H27N3O2 分子量:269.38300

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