| Product name | 2,4,5-trichlorophenol |
|---|
| Product number | - |
|---|---|
| Other names | RCRA waste no. U230 |
| Identified uses | For industry use only. 2,4,5-Trichlorophenol is used as a fungicide in paper and pulp mills, as an herbicide, and as an intermediate in the manufacture of other pesticides (e.g., the herbicides 2,4,5-trichlorophenoxyacetic acid and Silvex and the insecticide Ronnel). |
|---|---|
| Uses advised against | no data available |
| Company | MOLBASE (Shanghai) Biotechnology Co., Ltd. |
|---|---|
| Address | Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, Xuhui District, Shanghai, China |
| Telephone | +86(21)64956998 |
| Fax | +86(21)54365166 |
| Emergency phone number | +86-400-6021-666 |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
Acute toxicity - Oral, Category 4
Skin irritation, Category 2
Eye irritation, Category 2
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
2.2 GHS label elements, including precautionary statements| Pictogram(s) |   |
|---|---|
| Signal word | Warning |
| Hazard statement(s) | H302 Harmful if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H410 Very toxic to aquatic life with long lasting effects |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P273 Avoid release to the environment. |
| Response | P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P313 If skin irritation occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. P391 Collect spillage. |
| Storage | none |
| Disposal | P501 Dispose of contents/container to ... |
none
3.Composition/information on ingredients 3.1 Substances| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 2,4,5-trichlorophenol | 2,4,5-trichlorophenol | 95-95-4 | none | 100% |
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaledFresh air, rest.
In case of skin contactRemove contaminated clothes. To remove substance use polyethylene glycol 300 or vegetable oil. Rinse and then wash skin with water and soap.
In case of eye contactFirst rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
If swallowedRinse mouth. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayedSYMPTOMS: Symptoms of exposure to large amounts of this compound may include irritation of the skin, eyes, nose and throat. The dust may cause swelling and injury to the eyes. Eye contact may also result in conjunctivitis and slight to moderate corneal injuries. Other toxic effects include decrease of activity, motor weakness and convulsive seizures. It also causes lung, kidney and liver damage; an increase and then a decrease in respiratory rate, decrease in urine output, fever, increased bowel action and collapse. ACUTE/CHRONIC HAZARDS: This compound is an irritant of the skin, eyes, nose and throat. When heated to decomposition it emits toxic fumes of chloride ion; decomposition may be violent. There is limited evidence that this compound is a human carcinogen.
4.3 Indication of immediate medical attention and special treatment needed, if necessaryImmediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Phenols and related compounds/
5.Fire-fighting measures 5.1 Extinguishing media Suitable extinguishing mediaIf material /is/ involved in /a/ fire, extinguish fire using agent suitable for type of surrounding fire. Material itself does not burn or burns with difficulty. /Trichlorophenol/
5.2 Specific hazards arising from the chemicalLiterature sources indicate that this chemical is nonflammable.
5.3 Special protective actions for fire-fightersWear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures 6.1 Personal precautions, protective equipment and emergency proceduresUse personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautionsPersonal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning upLand Spill Dig a pit, pond, lagoon, or holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with plastic sheet to prevent dissolving in rain or fire fighting water. /Trichlorophenol/
7.Handling and storage 7.1 Precautions for safe handlingAvoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilitiesSeparated from strong oxidants and food and feedstuffs. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.Storage temp: ambient
8.Exposure controls/personal protection 8.1 Control parameters Occupational Exposure limit valuesno data available
Biological limit valuesno data available
8.2 Appropriate engineering controlsHandle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE) Eye/face protectionSafety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protectionWear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protectionWear dust mask when handling large quantities.
Thermal hazardsno data available
9.Physical and chemical properties| Physical state | white to off-white crystalline solid |
|---|---|
| Colour | Needles from alcohol, petroleum ether |
| Odour | Strong phenolic odor |
| Melting point/ freezing point | 19°C(lit.) |
| Boiling point or initial boiling point and boiling range | 115°C/10mmHg(lit.) |
| Flammability | Combustible under specific conditions. Gives off irritating or toxic fumes (or gases) in a fire. |
| Lower and upper explosion limit / flammability limit | no data available |
| Flash point | 95°C(lit.) |
| Auto-ignition temperature | no data available |
| Decomposition temperature | no data available |
| pH | Weak monobasic acid |
| Kinematic viscosity | no data available |
| Solubility | less than 1 mg/mL at 21.11°C |
| Partition coefficient n-octanol/water (log value) | log Kow = 3.72 |
| Vapour pressure | 1 mm Hg at 72.22°C ; 5 mm Hg at 102.11°C |
| Density and/or relative density | 1,678 g/cm3 |
| Relative vapour density | greater than 1 (Relative to Air) |
| Particle characteristics | no data available |
no data available
10.2 Chemical stabilityStable under recommended storage conditions.
10.3 Possibility of hazardous reactionsNon-combustible. /Trichlorophenol/2,4,5-TRICHLOROPHENOL is a weak monobasic acid. Incompatible with acid chlorides, acid anhydrides and oxidizing agents. Produces dioxin in alkaline medium at high temperatures
10.4 Conditions to avoidno data available
10.5 Incompatible materials... The reaction of 2,4,5-trichlorophenol in an alkaline medium at high temperatures ... /produces/ ... dioxin ... .
10.6 Hazardous decomposition productsWhen heated to decomp, it emits toxic fumes of /hydrogen chloride/ and explodes.
11.Toxicological information Acute toxicity- Oral: LD50 Rat oral 820 mg/kg; Solvent: fuel oil
- Inhalation: no data available
- Dermal: no data available
no data available
Serious eye damage/irritationno data available
Respiratory or skin sensitizationno data available
Germ cell mutagenicityno data available
CarcinogenicityEvaluation: There is limited evidence in humans for the carcinogenicity of combined exposures to polychlorophenols or to their sodium salts. ... There is inadequate evidence in experimental animals for the carcinogenicity of 2,4,5-trichlorophenol. ... Overall evaluation: Combined exposures to polychlorophenols or to their sodium salts are possibly carcinogenic to humans (Group 2B). /Polychlorophenols/
Reproductive toxicityNo information is available on the reproductive or developmental effects of 2,4,5-trichlorophenol in humans. In several studies of mice exposed to 2,4,5-trichlorophenol via gavage (experimentally placing the chemical in the stomach), no birth defects were observed. In one study, a reduction in litter size was reported. No changes in maternal or fetal parameters were noted in rats exposed to 2,4,5-trichlorophenol by injection. (4)
STOT-single exposureno data available
STOT-repeated exposureno data available
Aspiration hazardno data available
12.Ecological information 12.1 Toxicity- Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill) weight 1.16 g; Conditions: freshwater, static; Concentration: 1280 ug/L for 96 hr (95% confidence interval: 1160-1415 ug/L /32.7% purity
- Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna (Water Flea) age <24 hr neonate; Conditions: freshwater, static, 25°C, pH 8.0, hardness 150 mg/L CaCO3, alkalinity 121 mg/L CaCO3; Concentration: 2080 ug/L for 48 hr
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
AEROBIC: The rate of 2,4,5-trichlorophenol biodegradation (measured by CO2 evolution) in river water and sediment corresponded to half-lives of 690 and 23 days, respectively(1). Using the Japanese MITI test, 2,4,5-trichlorophenol present at 100 ppm underwent <30% degradation in 2 weeks using an activated sludge at 30 ppm(2). Mixed microbial cultures isolated from toluene and phenol activated sludge, resulted in 50% biodegradation of 2,4,5-trichlorophenol in 2 days(3). 2,4,5-Trichlorophenol, present at 50 mg/L, took >47 and >72 days for complete degradation when added to 2 different soil suspensions(4). 2,4,5-Trichlorophenol was aerobically degraded 72% and 9% in 80 days in non-sterile and sterile clay loam, respectively(5). Microbial degradation, volatilization, and photodecomposition were ruled out in the sterile soil indicating that other mechanisms contribute to degradation(5). An aerobic biodegradation half-life of 23 days was determined for 2,4,5-trichlorophenol from a river die-away test(6). Biodegradation half-life (measured by loss of UV absorbance) for 10 ug/L 2,4,5-trichlorophenol added to a soil suspension was 15 days(7). Soil microbes metabolized 2,4,5-trichlorophenol to 3,5-dichlorocatechol, 4-chlorocatechol, succinate, cis,cis-2,4-dichloromuconate, 2-chloro-4-(carboxymethylene)but-2-enolide, and chlorosuccinate(7).
12.3 Bioaccumulative potentialUsing carp (Cyprinus carpio) which were exposed over an 8-week period to 10 and 1 ug/L of 2,4,5-trichlorophenol, respective measured BCFs were 121-484 and 232-825(1). A log BCF of 3.28 was reported for fathead minnows exposed to 2,4,5-trichlorophenol for 28 days(2). According to a classification scheme(3), these BCF values suggest that bioconcentration in aquatic organisms is high to very high(SRC).
12.4 Mobility in soilKoc values of 89(1), 2300(2), and 1700 in Pahokee peat(3) have been reported. According to a classification scheme(4), these Koc values suggest that 2,4,5-trichlorophenol is expected to have high to slight mobility in soil. The pKa of 2,4,5-trichlorophenol is 7.43(5), indicating that this compound will exist partially in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(6).
12.5 Other adverse effectsno data available
13.Disposal considerations 13.1 Disposal methods ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packagingContainers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information 14.1 UN Number| ADR/RID: UN2020 | IMDG: UN2020 | IATA: UN2020 |
| ADR/RID: CHLOROPHENOLS, SOLID |
| IMDG: CHLOROPHENOLS, SOLID |
| IATA: CHLOROPHENOLS, SOLID |
| ADR/RID: 6.1 | IMDG: 6.1 | IATA: 6.1 |
| ADR/RID: III | IMDG: III | IATA: III |
| ADR/RID: yes | IMDG: yes | IATA: yes |
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Codeno data available
15.Regulatory information 15.1 Safety, health and environmental regulations specific for the product in question| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| 2,4,5-trichlorophenol | 2,4,5-trichlorophenol | 95-95-4 | none |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Not Listed. | ||
| Vietnam National Chemical Inventory | Not Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Creation Date | Aug 12, 2017 |
|---|---|
| Revision Date | Aug 12, 2017 |
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
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