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154447-36-6 2-吗啉代-8-苯基色酮

2-吗啉代-8-苯基色酮

英文名称:LY294002
CAS:

154447-36-6

分子式:C19H17NO3
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2-吗啉代-8-苯基色酮简介

LY294002 is a morpholine-containing chemical compound that is a potent inhibitor of numerous proteins, and a strong inhibitor of phosphoinositide 3-kinases (PI3Ks). It is generally considered a non-selective research tool, and should not be used for experiments aiming to target PI3K uniquely.
Two of these are the proto-oncogene serine/threonine-protein kinase (PIM1) and the phosphatidylinositol-4,5-bisphosphate 3-kinase P110 gamma|catalytic subunit gamma isoform. With an IC50 of 1.4 µM it is somewhat less potent than wortmannin, another well-known PI3 kinase inhibitor. However, LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly. Application of LY294002 causes a substantial acceleration of MEPP frequency (150 μM) at the frog neuromuscular junction through a mechanism that is independent of intraterminal calcium. LY294002 causes the release of MEPPs through a perturbation of synaptotagmin function.
LY294002 is also a BET inhibitor.

2-吗啉代-8-苯基色酮基本信息

中文名称 2-吗啉代-8-苯基色酮 英文名称 LY294002
中文别名

LY294002/PI3K抑制剂; 2-吗啉代-8-苯基-4-氧代-4H-1-苯并吡喃;

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英文别名

LY 294002 HYDROCHLORIDE; 2-Morpholino-8-phenyl-4-oxo-4H-1-benzopyran; 2-Morpholino-8-phenylchromone; 2-Morpholino-8-phenyl-4H-chromen-4-one;

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CAS号 154447-36-6 分子式 C19H17NO3
分子量 307.34300 精确质量 307.12100
PSA 42.68000 LOGP 3.36160

2-吗啉代-8-苯基色酮编号系统

MDL号 MFCD00270881

2-吗啉代-8-苯基色酮物化性质

外观与性状:
淡黄色固体
密度:
1.266 g/cm3
沸点:
494.6ºC at 760 mmHg
熔点:
182-184ºC
闪点:
253ºC
蒸汽压:
6.33E-10mmHg at 25°C
SDS 1.0 中文 展开
SDS 1.0 英文 展开
MSDS 中文 展开
1H NMR : Predict展开

核磁图谱 1H NMR : Predict

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2-吗啉代-8-苯基色酮
CAS号:154447-36-6 分子式:C19H17NO3 分子量:307.34300

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