3687-18-1 3-氨基-1-丙磺酸

3-氨基-1-丙磺酸

英文名称:3-Amino-1-propanesulfonic acid
CAS:

3687-18-1

分子式:C3H9NO3S
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3-氨基-1-丙磺酸简介

Homotaurine (3-amino-1-propanesulfonic acid (3-APS) or tramiprosate (INN)) is a synthetic organic compound. It is analogous to taurine, but with an extra carbon in its chain. It has GABAergic activity, apparently by mimicking GABA, which is it resembles.
Homotaurine was investigated in a Phase III clinical trial as a potential treatment for Alzheimer's disease that did not show efficacy in its primary endpoints. In preclinical studies it had been found to bind to soluble amyloid beta and inhibit the formation of neurotoxic aggregates. Homotaurine has also shown anticonvulsant activities, reduction in skeletal muscle tonus, and hypothermic activity.
Homotaurine has been reported as a GABA antagonist as well as a GABA agonist. In vitro studies have found that homotaurine is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy, becoming an antagonist and a displacing full agonist of GABA or baclofen at this receptor. In a study in rats, homotaurine reversed the catatonia induced by baclofen (the prototypical GABAB agonist), and was able to produce analgesia via the GABAB receptor, an effect that was abolished when CGP 35348, a GABAB receptor antagonist was applied.
One study in rats showed that homotaurine suppressed ethanol-stimulated dopamine release, as well as ethanol intake and preference in rats in a way similar to acamprosate. Acamprosate, the N-acetyl derivative of homotaurine, was approved by the FDA in 2004 to treat alcohol dependence.

3-氨基-1-丙磺酸基本信息

中文名称 3-氨基-1-丙磺酸 英文名称 3-Amino-1-propanesulfonic acid
中文别名

3-氨基-1-丙烷磺酸; 3-氨基丙烷磺酸; 高牛磺酸;

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英文别名

Homotaurine; 3-aminopropane-1-sulfonic acid; Tramiprosate;

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CAS号 3687-18-1 分子式 C3H9NO3S
分子量 139.17300 精确质量 139.03000
PSA 88.77000 LOGP 1.00410

3-氨基-1-丙磺酸编号系统

MDL号 MFCD00008225

3-氨基-1-丙磺酸物化性质

外观与性状:
白色晶体或结晶粉末
密度:
1.387 g/cm3
熔点:
293 °C (dec.)(lit.)
储存条件:
Store at 0-5°C

安全信息

安全说明:
S26-S36
WGK Germany:
1
危险类别码:
R36/37/38
海关编码:
2921199090
危险品标志:
Xi

生产方法及用途

用途

用作酒精中毒治疗剂阿坎酸的中间体。

SDS 1.0 中文 展开
SDS 1.0 英文 展开
MSDS 中文 展开
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核磁图谱 1H NMR : Predict

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国家名称 海关编码 海关数据更新时间 操作
中国 2921199090 2019-03 申报要素
美国 2921196090 2019-03 概述
印度 29211990 2019-03 概述
欧盟 29211999 2019-03 概述
英国 2921199990 2019-03 概述
日本 292119000 2019-03 概述
韩国 2921199090 2019-03 概述
加拿大 2921190000 2019-03 概述
3-氨基-1-丙磺酸
CAS号:3687-18-1 分子式:C3H9NO3S 分子量:139.17300

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