92339-11-2 碘克沙醇

碘克沙醇

英文名称:iodixanol
CAS:

92339-11-2

分子式:C35H44I6N6O15
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碘克沙醇简介

Iodixanol is a contrast agent, sold under the trade name Visipaque; it is also sold as a density gradient medium under the name OptiPrep. Visipaque is commonly used as a contrast agent during coronary angiography. It is the only iso-osmolar contrast agent, with an osmolality of 290 mOsm/kg H2O, the same as blood. It is sold in 2 main concentrations 270 mgI/ml and 320 mgI/ml - hence the name Visipaque 270 or 320. It is sold in single dose units and a large 500ml plastic bottle for multi-dose dispensing; It was originally made by Nycomed, which then merged with Amersham which finally was bought by Jeff Immelt to become GE Healthcare. The majority of Visipaque is made in Cork, Ireland, with additional plants in China and Oslo. All Iodixanol bulk powder is made in Norway by Axis-Shield and shipped to the various plants for final manufacture (distributed in the United States by Cosmo Bio USA).
A very similar product also manufactured by GE Healthcare is Omnipaque (Iohexol as the main drug substance).

碘克沙醇基本信息

中文名称 碘克沙醇 英文名称 iodixanol
中文别名

5,5'-((2-羟基-1,3-丙烷)双(乙酰亚氨))双(N,N'-二(2,3-二羟基丙基)-2,4,6-三碘-1,3-苯二甲酰胺; 碘海醇; 1,3-双(乙酰胺基)-N,N'-双[3,5-双(2,3-二羟丙基氨羰基)-2,4,6-三碘苯基]-2-羟基丙烷;

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英文别名

1,3-bis(acetylamino)-N,N'-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane; Iodixanolum [Latin]; Visipaque; Indixanol; 3,3',5,5'-tetrakis(2,3-dihydroxypropylcarbamoyl)-2,2',4,4',6,6'-hexaiodo-N,N'-(2-hydroxypropane-1,3-diyl)diacetanilide; visipaqueTM; 5-[acetyl-[3-[N-acetyl-3,5-bis(2,3-dihydroxypropylcarbamoyl)-2,4,6-triiodoanilino]-2-hydroxypropyl]amino]-1-N,3-N-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide; Iodixanolum; Visipaque 270; 3,3',5',5'-tetrakis(2,3-dixydroxypropylcarbamoyl)-2,2',4,4',6,6'-hexaiodo-N,N'-(2-hydroxypropane-1,3-diyl)diacetanilide; UNII-HW8W27HTXX; Visipaque 320;

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CAS号 92339-11-2 分子式 C35H44I6N6O15
分子量 1550.18000 精确质量 1549.71000
PSA 339.09000 LOGP -0.02330

碘克沙醇编号系统

UNII HW8W27HTXX

碘克沙醇物化性质

外观与性状:
灰白色至白色粉末
密度:
2.295 g/cm3
沸点:
1250.9ºC at 760 mmHg
熔点:
262-267ºC (dec.)
闪点:
710.3ºC
折射率:
1.751
稳定性:
Stable and nont reactive.
储存条件:
Store in original container according to temperature stated on container and in package insert.

安全信息

海关编码:
2924299090

生产方法及用途

生产方法

化合物(Ⅰ)和1,3-二氯-2-丙醇缩合,即得碘克沙醇。

用途

X-线造影剂。用于成人的心血管造影、脑血管造影(常规的与i.a. DSA)、外周动脉造影(常规的与i.a. DSA)、腹部血管造影(i.a. DSA)、尿路造影、静脉造影以及CT-增强检查。

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国家名称 海关编码 海关数据更新时间 操作
中国 2924299090 2019-03 申报要素
碘克沙醇
CAS号:92339-11-2 分子式:C35H44I6N6O15 分子量:1550.18000

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