|Other names||trans-Diethyl Stilbestrol|
|Identified uses||For industry use only. Veterinary Drug: GROWTH_PROMOTER|
|Uses advised against||no data available|
|Company||MOLBASE (Shanghai) Biotechnology Co., Ltd.|
|Address||Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, |
Xuhui District, Shanghai, China
|Emergency phone number||+86-400-6021-666|
|Service hours||Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).|
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity – single exposure, Category 3
Carcinogenicity, Category 1B
Reproductive toxicity, Category 1B
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 12.2 GHS label elements, including precautionary statements
|Signal word|| |
|Hazard statement(s)|| |
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
H350 May cause cancer
H360 May damage fertility or the unborn child
H410 Very toxic to aquatic life with long lasting effects
P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P273 Avoid release to the environment.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313 If eye irritation persists: Get medical advice/attention.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P312 Call a POISON CENTER/doctor/…if you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/ attention.
P391 Collect spillage.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to ...
none3.Composition/information on ingredients 3.1 Substances
|Chemical name||Common names and synonyms||CAS number||EC number||Concentration|
Consult a physician. Show this safety data sheet to the doctor in attendance.If inhaled
Fresh air, rest. Half-upright position. Refer immediately for medical attention.In case of skin contact
Remove contaminated clothes. Rinse skin with plenty of water or shower for at least 15 minutes. Refer immediately for medical attention.In case of eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.If swallowed
Rinse mouth. Do NOT induce vomiting. Give nothing to drink. Refer immediately for medical attention.4.2 Most important symptoms/effects, acute and delayed
SYMPTOMS: Symptoms of exposure to this compound via ingestion include dysmenorrhea, premenstrual-like syndrome, amenorrhea (during and after), increase in size of uterine fibromyomata, vaginal candidiasis, change in cervical eversion and of cervical secretion, cystitis-like syndrome; tenderness, enlargement and secretion of the breasts; abdominal cramps, bloating, cholestatic jaundice, chloasma or melasma, erythema multiforme, erythema nodosum, loss of scalp hair hemorrhagic eruptions, hirsutism, steepening of corneal curvature, intolerance to contact lenses, headache, migraine, dizziness, mental depression, chorea, decrease or increase in weight, reduced carbohydrate tolerance, aggravation of porphyria, edema and changes in libido. Gynaecomastia is the main side effect in the male. Exposure may also cause proliferation and withdrawal bleeding, sodium retention, nitrogen retention, alterations in liver function, jaundice, nausea and vomiting. It can cause male impotence and transsexual changes. It may also cause congenital malformation in the fetus. Human reproductive effects by ingestion include abnormal spermatogenesis, changes in the testes, epididymis and sperm duct; menstrual cycle changes or disorders, changes in female fertility, developmental abnormalities of the fetal urogenital system, germ cell effects in offspring and delayed effects in the newborn. ACUTE/CHRONIC HAZARDS: This chemical may be harmful if swallowed or inhaled. It may cause irritation of the skin, eyes, mucous membranes and upper respiratory tract. When heated to decomposition it emits toxic fumes of carbon monoxide and carbon dioxide.4.3 Indication of immediate medical attention and special treatment needed, if necessary
Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/5.Fire-fighting measures 5.1 Extinguishing media Suitable extinguishing media
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.5.2 Specific hazards arising from the chemical
Flash point data for this chemical are not available; however, it is probably combustible.5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.6.Accidental release measures 6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.6.2 Environmental precautions
Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.6.3 Methods and materials for containment and cleaning up
PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/7.Handling and storage 7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 184.108.40.206 Conditions for safe storage, including any incompatibilities
Separated from food and feedstuffs. Dry. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access.PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/8.Exposure controls/personal protection 8.1 Control parameters Occupational Exposure limit values
no data availableBiological limit values
no data available8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.8.3 Individual protection measures, such as personal protective equipment (PPE) Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.Respiratory protection
Wear dust mask when handling large quantities.Thermal hazards
no data available9.Physical and chemical properties
|Physical state||white crystalline powder|
|Colour||White crystalline powder|
|Melting point/ freezing point||169-175ºC|
|Boiling point or initial boiling point and boiling range||407.1ºC at 760mmHg|
|Flammability||Combustible. Gives off irritating or toxic fumes (or gases) in a fire.|
|Lower and upper explosion limit / flammability limit||no data available|
|pH||no data available|
|Kinematic viscosity||no data available|
|Solubility||In water:PRACTICALLY INSOLUBLE|
|Partition coefficient n-octanol/water (log value)||no data available|
|Vapour pressure||Pa at 20°C: 20|
|Density and/or relative density||1.107g/cm3|
|Relative vapour density||(air = 1): 5.3|
|Particle characteristics||no data available|
no data available10.2 Chemical stability
Stable under recommended storage conditions.10.3 Possibility of hazardous reactions
DIETHYLSTILBESTROL is incompatible with strong oxidizing agents, strong bases, acid chlorides and acid anhydrides .10.4 Conditions to avoid
no data available10.5 Incompatible materials
no data available10.6 Hazardous decomposition products
When heated to decomposition it emits acrid smoke and fumes.11.Toxicological information Acute toxicity
- Oral: LD50 Rat oral >3 g/kg
- Inhalation: no data available
- Dermal: no data available
no data availableSerious eye damage/irritation
no data availableRespiratory or skin sensitization
no data availableGerm cell mutagenicity
no data availableCarcinogenicity
The Human Health Assessment Group in EPA's Office of Health and Environmental Assessment has evaluated diethylstilbestrol for carcinogenicity. According to their analysis, the weight-of-evidence for diethylstilbestrol is group A, which is based on sufficient evidence in humans and sufficient evidence in animals. As a group A chemical, diethylstilbestrol is considered carcinogenic to humans.Reproductive toxicity
no data availableSTOT-single exposure
no data availableSTOT-repeated exposure
no data availableAspiration hazard
no data available12.Ecological information 12.1 Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
AEROBIC: Over a period of 6 days under aerobic conditions at 20°C, 500 mg/l diethylstilbestrol was resistant to biodegradation in two activated sludge samples and was slightly inhibitory in a third sample(1). Biodegradation studies of diethylstilbestrol have indicated this hormone is persistant in soil and feces(2).12.3 Bioaccumulative potential
An estimated BCF of 1600 was calculated for diethylstilbestrol(SRC), using a log Kow of 5.07(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is very high if diethylstilbestrol is not metabolized.12.4 Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc for diethylstilbestrol can be estimated to be 570,000(SRC). According to a classification scheme(2), this estimated Koc value suggests that diethylstilbestrol is expected to be immobile in soil.12.5 Other adverse effects
no data available13.Disposal considerations 13.1 Disposal methods Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.14.Transport information 14.1 UN Number
|ADR/RID: UN3077||IMDG: UN3077||IATA: UN3077|
|ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.|
|IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.|
|IATA: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.|
|ADR/RID: 9||IMDG: 9||IATA: 9|
|ADR/RID: III||IMDG: III||IATA: III|
|ADR/RID: yes||IMDG: yes||IATA: yes|
no data available14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available15.Regulatory information 15.1 Safety, health and environmental regulations specific for the product in question
|Chemical name||Common names and synonyms||CAS number||EC number|
|European Inventory of Existing Commercial Chemical Substances (EINECS)||Listed.|
|United States Toxic Substances Control Act (TSCA) Inventory||Listed.|
|China Catalog of Hazardous chemicals 2015||Not Listed.|
|New Zealand Inventory of Chemicals (NZIoC)||Listed.|
|Philippines Inventory of Chemicals and Chemical Substances (PICCS)||Not Listed.|
|Vietnam National Chemical Inventory||Listed.|
|Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)||Not Listed.|
|Creation Date||Aug 13, 2017|
|Revision Date||Aug 13, 2017|
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/