|Product name||Cyanogen bromide solution|
|Other names||carbononitridic bromide|
|Identified uses||For industry use only.|
|Uses advised against||no data available|
|Company||MOLBASE (Shanghai) Biotechnology Co., Ltd.|
|Address||Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, |
Xuhui District, Shanghai, China
|Emergency phone number||+86-400-6021-666|
|Service hours||Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).|
Acute toxicity - Oral, Category 2
Acute toxicity - Dermal, Category 2
Skin corrosion, Category 1A
Acute toxicity - Inhalation, Category 2
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 12.2 GHS label elements, including precautionary statements
|Signal word|| |
|Hazard statement(s)|| |
H300 Fatal if swallowed
H310 Fatal in contact with skin
H314 Causes severe skin burns and eye damage
H330 Fatal if inhaled
H410 Very toxic to aquatic life with long lasting effects
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P262 Do not get in eyes, on skin, or on clothing.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P284 [In case of inadequate ventilation] wear respiratory protection.
P273 Avoid release to the environment.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/…
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P310 Immediately call a POISON CENTER/doctor/…
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P320 Specific treatment is urgent (see ... on this label).
P391 Collect spillage.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to ...
none3.Composition/information on ingredients 3.1 Substances
|Chemical name||Common names and synonyms||CAS number||EC number||Concentration|
|Cyanogen bromide solution||Cyanogen bromide solution||506-68-3||none||100%|
Consult a physician. Show this safety data sheet to the doctor in attendance.If inhaled
Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.In case of skin contact
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .In case of eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.If swallowed
Refer for medical attention . See Notes. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!).4.2 Most important symptoms/effects, acute and delayed
Super toxic; probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for a 70 kg (150 lb.) person. Vapors are highly irritant and very poisonous. Individuals with chronic diseases of the kidneys, respiratory tract, skin, or thyroid are at greater risk of developing toxic cyanide effects. (EPA, 1998)4.3 Indication of immediate medical attention and special treatment needed, if necessary
Cyanokit is indicated for the treatment of known or suspected cyanide poisoning. ... If clinical suspicion of cyanide poisoning is high, Cyanokit should be administered without delay.... Cyanokit (hydroxocobalamin for injection) 5 g is a cyanide antidote package which contains two colorless 250 mL glass vials, each of which contains 2.5 g dark red lyophilized hydroxocobalamin, pH adjusted with hydrochloric acid, two transfer spikes, one IV administration set, one quick use reference guide and one package insert. The action of Cyanokit in the treatment of cyanide poisoning is based on its ability to bind cyanide ions. ...Caution should be exercised when administering other cyanide antidotes simultaneously with Cyanokit, as the safety of co-administration has not been established. If a decision is made to administer another cyanide antidote with Cyanokit, these drugs should not be administered concurrently in the same IV line. /Cyanide/5.Fire-fighting measures 5.1 Extinguishing media Suitable extinguishing media
If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use foam, dry chemical, or carbon dioxide. Cool all affected containers with flooding quantities of water. Do not use water on material itself. If large quantities of combustibles are involved, use water in flooding quantities of spray and fog.5.2 Specific hazards arising from the chemical
Cyanogen bromide is not combustible itself, but impure cyanogen bromide decomposes rapidly and tends to explode. A violent reaction may take place on contact with large quantities of acid. Vapors are highly irritating. When material is heated to decomposition, it emits very toxic fumes of cyanide and bromide. Avoid water, acids. Avoid physical damage, contact with acids or water, and store away from a location where water may be needed for fire control. (EPA, 1998)5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.6.Accidental release measures 6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.6.2 Environmental precautions
Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. Carefully collect remainder. Then store and dispose of according to local regulations.6.3 Methods and materials for containment and cleaning up
In the event of a spill, sweep up cyanogen bromide, place in an appropriate container, and dispose of properly. Respiratory and appropriate impermeable protective gloves and clothing should be worn while conducting cleanup of this highly toxic substance.7.Handling and storage 7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 184.108.40.206 Conditions for safe storage, including any incompatibilities
Separated from food and feedstuffs. See Chemical Dangers. Dry. Well closed.Cyanogen bromide can polymerize violently on prolonged storage at ambient temperature. ... /In the laboratory/ Containers of cyanogen bromide should be kept tightly sealed and stored under nitrogen in a secondary container in a refrigerator.8.Exposure controls/personal protection 8.1 Control parameters Occupational Exposure limit values
no data availableBiological limit values
no data available8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.8.3 Individual protection measures, such as personal protective equipment (PPE) Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.Respiratory protection
Wear dust mask when handling large quantities.Thermal hazards
no data available9.Physical and chemical properties
|Physical state||white crystalline solid|
|Colour||White hygroscopic needles|
|Melting point/ freezing point||49-54ºC|
|Boiling point or initial boiling point and boiling range||61-62ºC|
|Flammability||Not combustible but forms flammable gas on contact with water or damp air. Gives off irritating or toxic fumes (or gases) in a fire.|
|Lower and upper explosion limit / flammability limit||no data available|
|Auto-ignition temperature||Not Applicable. Not flammable. (USCG, 1999)|
|Decomposition temperature||no data available|
|pH||no data available|
|Kinematic viscosity||no data available|
|Solubility||In water, soluble with hydrolysis|
|Partition coefficient n-octanol/water (log value)||no data available|
|Vapour pressure||100 mm Hg ( 22.6 °C)|
|Density and/or relative density||1.443|
|Relative vapour density||3.65 (vs air)|
|Particle characteristics||no data available|
no data available10.2 Chemical stability
Cyanogen bromide is moderately endothermic ... & shows evidence of instability.10.3 Possibility of hazardous reactions
NoncombustibleThe vapour is heavier than air.CYANOGEN BROMIDE is not combustible itself, but impure cyanogen bromide decomposes rapidly and tends to explode. A violent reaction may take place on contact with large quantities of acid. Avoid physical damage, contact with acids or water, and store away from a location where water may be needed for fire control. [EPA, 1998]. Benzene and cyanogen halides yield HCl as a byproduct (Hagedorn, F. H. Gelbke, and Federal Republic of Germany. 2002. Nitriles. In Ullmann's Encyclopedia of Industrial Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA.).10.4 Conditions to avoid
no data available10.5 Incompatible materials
Reacts with acids, water to release highly toxic hydrogen cyanide.10.6 Hazardous decomposition products
... If involved in a fire decomposes to produce toxic gases.11.Toxicological information Acute toxicity
- Oral: no data available
- Inhalation: no data available
- Dermal: no data available
no data availableSerious eye damage/irritation
no data availableRespiratory or skin sensitization
no data availableGerm cell mutagenicity
no data availableCarcinogenicity
no data availableReproductive toxicity
no data availableSTOT-single exposure
no data availableSTOT-repeated exposure
no data availableAspiration hazard
no data available12.Ecological information 12.1 Toxicity
- Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill) length 33-75 mm; Conditions: freshwater, static, 23°C, pH 7.6-7.9, hardness 55 mg/L CaCO3; Concentration: 240 ug/L for 96 hr /formulated product
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
no data available12.3 Bioaccumulative potential
no data available12.4 Mobility in soil
no data available12.5 Other adverse effects
no data available13.Disposal considerations 13.1 Disposal methods Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.14.Transport information 14.1 UN Number
|ADR/RID: UN3390||IMDG: UN3390||IATA: UN3390|
|ADR/RID: TOXIC BY INHALATION LIQUID, CORROSIVE, N.O.S. with an LC50 lower than or equal to 1000 ml/m3 and saturated vapour concentration greater than or equal to 10 LC50|
|IMDG: TOXIC BY INHALATION LIQUID, CORROSIVE, N.O.S. with an LC50 lower than or equal to 1000 ml/m3 and saturated vapour concentration greater than or equal to 10 LC50|
|IATA: TOXIC BY INHALATION LIQUID, CORROSIVE, N.O.S. with an LC50 lower than or equal to 1000 ml/m3 and saturated vapour concentration greater than or equal to 10 LC50|
|ADR/RID: 6.1||IMDG: 6.1||IATA: 6.1|
|ADR/RID: I||IMDG: I||IATA: I|
|ADR/RID: yes||IMDG: yes||IATA: yes|
no data available14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available15.Regulatory information 15.1 Safety, health and environmental regulations specific for the product in question
|Chemical name||Common names and synonyms||CAS number||EC number|
|Cyanogen bromide solution||Cyanogen bromide solution||506-68-3||none|
|European Inventory of Existing Commercial Chemical Substances (EINECS)||Listed.|
|United States Toxic Substances Control Act (TSCA) Inventory||Listed.|
|China Catalog of Hazardous chemicals 2015||Listed.|
|New Zealand Inventory of Chemicals (NZIoC)||Listed.|
|Philippines Inventory of Chemicals and Chemical Substances (PICCS)||Listed.|
|Vietnam National Chemical Inventory||Not Listed.|
|Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)||Listed.|
|Creation Date||Aug 12, 2017|
|Revision Date||Aug 12, 2017|
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/