68786-66-3 三氯苯哒唑

三氯苯哒唑

英文名称:Triclabendazole
CAS:

68786-66-3

分子式:C14H9Cl3N2OS
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三氯苯哒唑简介

Triclabendazole (commercial names: veterinary, liquid: Fasinex; human, tablets: Egaten, both manufactured by Novartis) is a member of the benzimidazole family of anthelmintics. The benzimidazole drugs share a common molecular structure, triclabendazole being the exception in having a chlorinated benzene ring but no carbamate group. Benzimidazoles such as triclabendazole are generally accepted to bind to beta-tubulin and prevent the polymerization of the microtubules of which they are part.
Triclabendazole was initially only developed as an oral route drug, and displays high efficacy against both immature and adult liver flukes.
Since late 1990s, triclabendazole became available as a generic drug, as patents expired in many countries. Many products were developed then. Among them, Trivantel 15, a 15% triclabendazole suspension, was launched by Agrovet Market Animal Health in the early 2000s. In 2009, the first triclabendazole injectable solution (combined with ivermectin) was developed and launched, also by Agrovet Market Animal Health. The product, Fasiject Plus, a triclabendazole 36% and ivermectin 0.6% solution, is designed to treat infections by Fasciola hepatica (both immature and adult liver flukes), roundworms and ectoparasites, as well.
It is on the World Health Organization's List of Essential Medicines, the most important medication needed in a basic health system.

三氯苯哒唑基本信息

中文名称 三氯苯哒唑 英文名称 Triclabendazole
中文别名

5-氯-6-(2,3-二氯苯氧基)-2-(甲硫基)-1H-苯并咪唑; 三氯苯咪唑; 5-氯-6-(2,3-二氯苯氧基)-2-甲硫基-1H-苯并咪唑; 三氯苯达唑;

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英文别名

6-Chloro-5-(2,3-dichlorophenoxy)-2-methylthio-benzimidazole;

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CAS号 68786-66-3 分子式 C14H9Cl3N2OS
分子量 359.65800 精确质量 357.95000
PSA 63.21000 LOGP 6.03730

三氯苯哒唑编号系统

MDL号 MFCD03147039

三氯苯哒唑物化性质

外观与性状:
白色至棕色结晶粉末
密度:
1.59 g/cm3
沸点:
495.9ºCat 760 mmHg
熔点:
175-176°C
闪点:
253.7ºC
折射率:
1.724
稳定性:
Stability
储存条件:
库房低温,通风,干燥

安全信息

安全说明:
S26; S36
危险类别码:
R36/37/38
WGK Germany:
3
海关编码:
2933990090
危险品标志:
Xn
SDS 1.0 中文 展开
SDS 1.0 英文 展开
1H NMR : Predict展开

核磁图谱 1H NMR : Predict

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国家名称 海关编码 海关数据更新时间 操作
中国 2933990090 2019-03 申报要素
美国 2933998290 2019-03 概述
印度 29339900 2019-03 概述
欧盟 29339980 2019-03 概述
英国 2933998090 2019-03 概述
日本 293399090 2019-03 概述
韩国 2933999000 2019-03 概述
加拿大 2933990090 2019-03 概述
三氯苯哒唑
CAS号:68786-66-3 分子式:C14H9Cl3N2OS 分子量:359.65800

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