| Product name | chlorothalonil |
|---|
| Product number | - |
|---|---|
| Other names | meta-TCPN |
| Identified uses | For industry use only. |
|---|---|
| Uses advised against | no data available |
| Company | MOLBASE (Shanghai) Biotechnology Co., Ltd. |
|---|---|
| Address | Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, Xuhui District, Shanghai, China |
| Telephone | +86(21)64956998 |
| Fax | +86(21)54365166 |
| Emergency phone number | +86-400-6021-666 |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
Serious eye damage, Category 1
Skin sensitization, Category 1
Acute toxicity - Inhalation, Category 2
Specific target organ toxicity – single exposure, Category 3
Carcinogenicity, Category 2
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
2.2 GHS label elements, including precautionary statements| Pictogram(s) |     |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H318 Causes serious eye damage H317 May cause an allergic skin reaction H330 Fatal if inhaled H335 May cause respiratory irritation H351 Suspected of causing cancer H410 Very toxic to aquatic life with long lasting effects |
| Precautionary statement(s) | |
| Prevention | P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P284 [In case of inadequate ventilation] wear respiratory protection. P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P273 Avoid release to the environment. |
| Response | P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310 Immediately call a POISON CENTER/doctor/… P302+P352 IF ON SKIN: Wash with plenty of water/... P333+P313 If skin irritation or rash occurs: Get medical advice/attention. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P320 Specific treatment is urgent (see ... on this label). P312 Call a POISON CENTER/doctor/…if you feel unwell. P308+P313 IF exposed or concerned: Get medical advice/ attention. P391 Collect spillage. |
| Storage | P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to ... |
none
3.Composition/information on ingredients 3.1 Substances| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| chlorothalonil | chlorothalonil | 1897-45-6 | none | 100% |
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaledFresh air, rest.
In case of skin contactRemove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
In case of eye contactRinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.
If swallowedRinse mouth. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayedSYMPTOMS: Symptoms of exposure to this compound include dermatitis and gastrointestinal, skin and upper respiratory tract irritation. ACUTE/CHRONIC HAZARDS: This compound is a positive animal carcinogen. When heated to decomposition it emits toxic fumes of chloride ion, NOx and cyanide ion.
4.3 Indication of immediate medical attention and special treatment needed, if necessary1. Wash off dermal contamination with soap and water. Remove contamination of the eyes by flushing with copious amounts of water. If irritation persists, specialized medical care should be obtained. /Substituted benzenes/
5.Fire-fighting measures 5.1 Extinguishing media Suitable extinguishing mediaFire Extinguishing Media: CO2, foam, dry chemical or water.
5.2 Specific hazards arising from the chemicalLiterature sources indicate that this compound is nonflammable.
5.3 Special protective actions for fire-fightersWear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures 6.1 Personal precautions, protective equipment and emergency proceduresUse personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautionsPersonal protection: chemical protection suit and protective gloves. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning upSolid spillage should be picked up with an industrial vacuum cleaner and disposed of in accordance with local regulations.
7.Handling and storage 7.1 Precautions for safe handlingAvoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilitiesProvision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Store in an area without drain or sewer access.Keep in cool, dry, ventilated place.
8.Exposure controls/personal protection 8.1 Control parameters Occupational Exposure limit valuesno data available
Biological limit valuesno data available
8.2 Appropriate engineering controlsHandle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE) Eye/face protectionSafety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protectionWear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protectionWear dust mask when handling large quantities.
Thermal hazardsno data available
9.Physical and chemical properties| Physical state | white crystalline powder |
|---|---|
| Colour | Colorless crystals |
| Odour | Odorless in pure form |
| Melting point/ freezing point | 251°C(lit.) |
| Boiling point or initial boiling point and boiling range | 350°C(lit.) |
| Flammability | Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire. |
| Lower and upper explosion limit / flammability limit | no data available |
| Flash point | 126°C(lit.) |
| Auto-ignition temperature | no data available |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | less than 0.1 mg/mL at 21.11°C |
| Partition coefficient n-octanol/water (log value) | log Kow = 3.05 |
| Vapour pressure | 4.36E-05mmHg at 25°C |
| Density and/or relative density | 1.71g/cm3 |
| Relative vapour density | no data available |
| Particle characteristics | no data available |
no data available
10.2 Chemical stabilityThermally stable at ambient temperatures. Stable to u.v. light in aqueous media and in crystalline state. Stable in acidic and moderately alkaline aqueous solutions; slow hydrolysis at pH >9.
10.3 Possibility of hazardous reactionsChlorothalonil is non-flammable and non-explosive.CHLOROTHALONIL is stable in neutral or acidic aqueous media. May react violently with strong oxidizing acids [Farm Chemicals Handbook]. Incompatible with other oxidizing agents such as peroxides and epoxides. Breaks down slowly in basic aqueous media (half-life 38.1 days at pH 9). [Farm Chemicals Handbook].
10.4 Conditions to avoidno data available
10.5 Incompatible materialsCyanides
10.6 Hazardous decomposition productsMay decompose at high temp to emit hydrogen chloride.
11.Toxicological information Acute toxicity- Oral: LD50 Mouse oral 3700 mg/kg
- Inhalation: LC50 Rat inhalation 310 mg/cu m/1hr
- Dermal: LD50 Rabbit (albino) percutaneous >5000 mg/kg
no data available
Serious eye damage/irritationno data available
Respiratory or skin sensitizationno data available
Germ cell mutagenicityno data available
CarcinogenicityCancer Classification: Group B2 Probable Human Carcinogen
Reproductive toxicityno data available
STOT-single exposureno data available
STOT-repeated exposureno data available
Aspiration hazardno data available
12.Ecological information 12.1 Toxicity- Toxicity to fish: LC50; Species: /Oncorhynchus mykiss/ (Rainbow trout); Concentration: 76 ug/L for 96 hr /Technical chlorothalonil; conditions of bioassay not specified
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea) age <24 hr; Conditions: static; Concentration: 70 ppb for 48 hr (95% confidence limit: 34.2-143 ppb); Effect: intoxication, immobilization) /96% AI formulated product
- Toxicity to algae: EC50; Species: Pseudokirchneriella subcapitata (Green algae); Conditions: static; Concentration: 190 ppb/120 hr (95% confidence limit: 180-210 ppb); Effect: decreased population abundance /97.9% AI formulated product
- Toxicity to microorganisms: no data available
AEROBIC: In an aerobic grab sample study, 60.5% chlorothalonil (initial concentration of 38 ppm) remained in an alluvial silty loam (25°C and pH 6.4) after 7 days(1). At an initial concentration of 40 ppm, 67.5% (20°C) and 45.0% (25°C) chlorothalonil remained after 7 days in an alluvial silty loam (pH 6.4) held at a 60% moisture capacity(1). In the same soil held at moisture capacities of 100, 60, 40, and 20%, the amount of chlorothalonil (initial concentration of 40 ppm) remaining was determined to be 85, 22, 45, and 65%, respectively, after 7 days. Chlorothalonil biodegraded mainly through dechlorination and partly by substitution reaction yielding the biodegradation products: isophthalonitrile, mono-, di- and tri-chlorinated isophthalonitriles, 2,5,6-trichloro-4-hydroxyisophthalonitrile and 2,5,6-trichloro-4-methoxyisophthalonitrile(1). Aerobic biodegradation half-lives of chlorothalonil in four different soils were reported as 10, 10, 15 and 40 days(2). After 60 days the metabolite 2,5,6-trichloro-4-hydroxyisophtalonitrile was present at up to 32% of the initially applied amount; the metabolite 3-cyano-2,4,5,6-tetrachlorobenzamide was present at up to about 7% at both days 7 and 16 of the study. Aerobic aquatic half-lives of chlorothalonil typically range from 2 to 200 hours(2). Other reported metabolites are 1,3-dicarbamoyl-2,4,5,6-tetrachlorobenzene, 1-carbamoyl-3-cyano-4-hydroxy-2,5,6-trichlorobenzene, 2,4,6-trichloro-4-(methylthio)isophthalonitrile and pentachloronitrobenzene(3).
12.3 Bioaccumulative potentialBioconcentration factors of 75 (edible) and 264 (whole body) were measured for chlorothalonil in bluegill sunfish(1). BCF values of 9.4 (edible) and 16 (whole body) were reported for catfish(1). Carp exposed to 3 ug/L chlorothalonil over a 6 week incubation period had reported maximum BCF values of 125 (2). A BCF of 264 was determined in bluegill (Lepomis macrochirus) exposed for 28 days(3). According to a classification scheme(4), these BCF values suggest bioconcentration in aquatic organisms can be low to high(SRC). Chlorothalonil BAFs wet weight and lipid based in zooplankton from three lakes in southern Ontario, Canada were 14-1500 and 140-190,000, respectively; samples were collected in 2003 and 2004(5).
12.4 Mobility in soilA Koc value of 1800 has been determined based on adsorption isotherms of chlorothalonil on 3 black soils and 1 clay mineral, Na-bentonite soil(1). Other reported Koc values are 1300 to 14,000(2). Laboratory batch equilibrium studies with four soils showed chlorothalonil to possess limited mobility in silty clay loam, silt, sandy loam, and sand with calculated Koc values were 1400, 7000, 1100, and 900, respectively(3). According to a classification scheme(4), these Koc values suggest the mobility of chlorothalonil in soils will be low to immobile(SRC). The Koc of sediment from recycling ponds was 2270 to 2450(5).
12.5 Other adverse effectsno data available
13.Disposal considerations 13.1 Disposal methods ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packagingContainers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information 14.1 UN Number| ADR/RID: UN3439 | IMDG: UN3439 | IATA: UN3439 |
| ADR/RID: NITRILES, SOLID, TOXIC, N.O.S. |
| IMDG: NITRILES, SOLID, TOXIC, N.O.S. |
| IATA: NITRILES, SOLID, TOXIC, N.O.S. |
| ADR/RID: 6.1 | IMDG: 6.1 | IATA: 6.1 |
| ADR/RID: II | IMDG: II | IATA: II |
| ADR/RID: yes | IMDG: yes | IATA: yes |
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Codeno data available
15.Regulatory information 15.1 Safety, health and environmental regulations specific for the product in question| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| chlorothalonil | chlorothalonil | 1897-45-6 | none |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Not Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Creation Date | Aug 11, 2017 |
|---|---|
| Revision Date | Aug 11, 2017 |
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
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