| Product name | ethoprophos |
|---|
| Product number | - |
|---|---|
| Other names | ETHOPROP |
| Identified uses | For industry use only. |
|---|---|
| Uses advised against | no data available |
| Company | MOLBASE (Shanghai) Biotechnology Co., Ltd. |
|---|---|
| Address | Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, Xuhui District, Shanghai, China |
| Telephone | +86(21)64956998 |
| Fax | +86(21)54365166 |
| Emergency phone number | +86-400-6021-666 |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
Acute toxicity - Oral, Category 3
Acute toxicity - Dermal, Category 1
Skin sensitization, Category 1
Acute toxicity - Inhalation, Category 2
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
2.2 GHS label elements, including precautionary statements| Pictogram(s) |   |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H301 Toxic if swallowed H310 Fatal in contact with skin H317 May cause an allergic skin reaction H330 Fatal if inhaled H410 Very toxic to aquatic life with long lasting effects |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P262 Do not get in eyes, on skin, or on clothing. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P284 [In case of inadequate ventilation] wear respiratory protection. P273 Avoid release to the environment. |
| Response | P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/… P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P310 Immediately call a POISON CENTER/doctor/… P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P333+P313 If skin irritation or rash occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P320 Specific treatment is urgent (see ... on this label). P391 Collect spillage. |
| Storage | P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed. |
| Disposal | P501 Dispose of contents/container to ... |
none
3.Composition/information on ingredients 3.1 Substances| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| ethoprophos | ethoprophos | 13194-48-4 | none | 100% |
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaledFresh air, rest. Artificial respiration may be needed. Refer immediately for medical attention.
In case of skin contactRemove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention. Wear protective gloves when administering first aid.
In case of eye contactFirst rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
If swallowedRinse mouth. Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention.
4.2 Most important symptoms/effects, acute and delayedThis material is extremely toxic; the probable oral lethal dose for humans is 5-50 mg/kg, or between 7 drops and 1 teaspoonful for a 150 lb. person. It is a cholinesterase inhibitor which affects the nervous system. (EPA, 1998)
4.3 Indication of immediate medical attention and special treatment needed, if necessaryAirway protection. Ensure that a clear airway exists. Intubate the patients and aspirate the secretions with a large-bore suction device if necessary. Administer oxygen by mechanically assisted pulmonary ventilation if respiration is depressed. Improve tissue oxygenation as much as possible before administering atropine, so as to minimize the risk of ventricular fibrillation. In severe poisonings, it may be necessary to support pulmonary ventilation mechanically for several days. /Organophosphate pesticides/
5.Fire-fighting measures 5.1 Extinguishing media Suitable extinguishing mediaIf material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide. /Organophosphorus pesticides, liquid, flammable, toxic; Organophosphorus pesticides, liquid, toxic/
5.2 Specific hazards arising from the chemical(Non-Specific -- Organophosphorus Pesticide, Liquid, n.o.s.) Container may explode in heat of fire. Fire and runoff from fire control water may produce irritating or poisonous gases. Stable in water. Hydrolyzed in alkali. (EPA, 1998)
5.3 Special protective actions for fire-fightersWear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures 6.1 Personal precautions, protective equipment and emergency proceduresUse personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautionsPersonal protection: complete protective clothing including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment.
6.3 Methods and materials for containment and cleaning upEnvironmental considerations: Air spill: Apply water spray or mist to knock down vapors. /Organophosphorus pesticides, liquid, flammable, toxic; Organophosphorus pesticides, liquid, toxic; Organophosphorus pesticides, solid, toxic/
7.Handling and storage 7.1 Precautions for safe handlingAvoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilitiesProvision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Store in an area without drain or sewer access. Ventilation along the floor.
8.Exposure controls/personal protection 8.1 Control parameters Occupational Exposure limit valuesno data available
Biological limit valuesno data available
8.2 Appropriate engineering controlsHandle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE) Eye/face protectionSafety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protectionWear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protectionWear dust mask when handling large quantities.
Thermal hazardsno data available
9.Physical and chemical properties| Physical state | Ethorop is one of a family of organophosphorus pesticides. It is combustible though it may require some effort to ignite. It is very toxic by skin absorption and inhalation. It may or may not be water soluble. |
|---|---|
| Colour | Pale yellow liquid |
| Odour | no data available |
| Melting point/ freezing point | -13ºC |
| Boiling point or initial boiling point and boiling range | 86-91ºC |
| Flammability | Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Heating will cause rise in pressure with risk of bursting. |
| Lower and upper explosion limit / flammability limit | no data available |
| Flash point | 100ºC |
| Auto-ignition temperature | no data available |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | Readily sol in most organic solvents |
| Partition coefficient n-octanol/water (log value) | log Kow = 3.59 @ 21°C |
| Vapour pressure | 0.00111mmHg at 25°C |
| Density and/or relative density | 1.106g/cm3 |
| Relative vapour density | (air = 1): 8.4 |
| Particle characteristics | no data available |
no data available
10.2 Chemical stabilityVery stable in neutral and weakly acidic media. Rapidly hydrolysed in alkaline media. Stable in water up to 100°C at pH 7.
10.3 Possibility of hazardous reactionsOrganothiophosphates, such as ETHOPROPHOS, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
10.4 Conditions to avoidno data available
10.5 Incompatible materialsIncompatible with alkaline materials.
10.6 Hazardous decomposition productsWhen heated to decomposition it emits very toxic fumes of /phosphorus oxides and sulfur oxides/.
11.Toxicological information Acute toxicity- Oral: LD50 Rat oral (male) 61 mg/kg
- Inhalation: no data available
- Dermal: LD50 Rabbit percutaneous 26 mg/kg
no data available
Serious eye damage/irritationno data available
Respiratory or skin sensitizationno data available
Germ cell mutagenicityno data available
CarcinogenicityCancer Classification: Likely to be Carcinogenic to Humans
Reproductive toxicityno data available
STOT-single exposureno data available
STOT-repeated exposureno data available
Aspiration hazardno data available
12.Ecological information 12.1 Toxicity- Toxicity to fish: LC50 Lepomis macrochirus (Bluegill) 2.07 mg/l/96 hr /Conditions of bioassay not specified
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
During ethoprop metabolism studies, it was observed that ethoprop did not metabolize in sterilized soils, but did in nonsterile soils(1). Soil from ethoprop treated plots in the Midwestern US were studied to determine ethoprop persistence(1); half-lives of 5-12 days were observed at application rates of 1-2 lb/acre granular formulation(1); when applied as a liquid formulation to VA soil, half-lives of 3-4 days were observed(1). Addition of ethoprop to soil has been observed to stimulate microbial oxygen consumption(2). During 4-week soil incubation studies using 1-ethyl-14C-labeled ethoprop, (14)CO2 evolution ranged from 23.4 to 50.9% in soils having no previous organophosphorus exposure and soils having prior exposure to isofenphos and fonophos(3); (14)CO2 from ethoprop was greater in soil having no prior exposure to the other pesticides(3). Mineralization of ethoprop was found to occur faster in soils that had been treated previously with ethoprop as compared to no prior treatment indicating microbial adaptation(4); during a 1 wk incubation, 32.7% mineralized in previously treated soil and 19.9% mineralized in untreated soil(4). Faster biodegradation in previously ethoprop treated soils was also noted in another study(5); sterilization of soils drastically reduced disappearance rates of ethoprop(5). The soil half-life of ethoprop can range from 3 to 56 days(6). In various field studies, soil half-lives of 2-12 weeks were determined(7). In soil column studies, ethoprop had the following half-lives(8): in silty loam (12 days at 20°C to 89 days at 2°C), in sandy loam (16 days at 20°C to 144 days at 2°C), in humous loamy sand (73 days at 20°C to 347 days at 6°C)(8). The half-lives of ethoprop in sterile and non-sterile soil from a banana plantation in Jamaica, with heavy ethoprop use, were 28.8 and 10.9 days, respectively(9).
12.3 Bioaccumulative potentialUsing an intermittent flow-through system, an ethoprop BCF range of 4 to 17 was measured in juvenile sheepshead minnow over a 28 day exposure period(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soilIn adsorption studies using silty clay loam, silt loam and two sandy loam soils, ethoprop adsorption was found to increase as soil organic matter increased(1); adsorption was to a great extent reversible indicating that the major interaction between ethoprop and the adsorptive surfaces was hydrophobic bonding(1); experimentally determined Koc values (values not reported) place ethoprop in the medium soil mobility class(1). The US Dept Agric's Pesticide Properties Database lists a Koc value of 70 for ethoprop(2). Koc values of 120.6 and 76.0 have been reported for Riverhead and Rhinebeck soils, respectively(3). According to a classification scheme(4), these Koc values suggest that ethoprop is expected to have high mobility in soil.
12.5 Other adverse effectsno data available
13.Disposal considerations 13.1 Disposal methods ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packagingContainers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information 14.1 UN Number| ADR/RID: UN2810 | IMDG: UN2810 | IATA: UN2810 |
| ADR/RID: TOXIC LIQUID, ORGANIC, N.O.S. |
| IMDG: TOXIC LIQUID, ORGANIC, N.O.S. |
| IATA: TOXIC LIQUID, ORGANIC, N.O.S. |
| ADR/RID: 6.1(a) | IMDG: 6.1(a) | IATA: 6.1(a) |
| ADR/RID: II | IMDG: II | IATA: II |
| ADR/RID: yes | IMDG: yes | IATA: yes |
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Codeno data available
15.Regulatory information 15.1 Safety, health and environmental regulations specific for the product in question| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| ethoprophos | ethoprophos | 13194-48-4 | none |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Not Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Not Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Not Listed. | ||
| Vietnam National Chemical Inventory | Not Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Not Listed. | ||
| Creation Date | Aug 14, 2017 |
|---|---|
| Revision Date | Aug 14, 2017 |
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
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