|Identified uses||For industry use only. Food additives -> Flavoring Agents|
|Uses advised against||no data available|
|Company||MOLBASE (Shanghai) Biotechnology Co., Ltd.|
|Address||Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, |
Xuhui District, Shanghai, China
|Emergency phone number||+86-400-6021-666|
|Service hours||Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).|
Flammable liquids, Category 3
Skin irritation, Category 2
Serious eye damage, Category 1
Specific target organ toxicity – single exposure, Category 3
Specific target organ toxicity – single exposure, Category 32.2 GHS label elements, including precautionary statements
|Signal word|| |
|Hazard statement(s)|| |
H226 Flammable liquid and vapour
H315 Causes skin irritation
H318 Causes serious eye damage
H335 May cause respiratory irritation
H336 May cause drowsiness or dizziness
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P233 Keep container tightly closed.
P240 Ground and bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.
P242 Use non-sparking tools.
P243 Take action to prevent static discharges.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P264 Wash ... thoroughly after handling.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].
P370+P378 In case of fire: Use ... to extinguish.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P313 If skin irritation occurs: Get medical advice/attention.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P310 Immediately call a POISON CENTER/doctor/…
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P312 Call a POISON CENTER/doctor/…if you feel unwell.
P403+P235 Store in a well-ventilated place. Keep cool.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to ...
none3.Composition/information on ingredients 3.1 Substances
|Chemical name||Common names and synonyms||CAS number||EC number||Concentration|
Consult a physician. Show this safety data sheet to the doctor in attendance.If inhaled
Fresh air, rest.In case of skin contact
Remove contaminated clothes. Rinse skin with plenty of water or shower.In case of eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.If swallowed
Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer for medical attention .4.2 Most important symptoms/effects, acute and delayed
Contact with eyes is extremely irritating and may cause burns. Breathing vapors will be irritating to the nose and throat. In high concentrations, may cause nausea, dizziness, headache, and stupor. (USCG, 1999)4.3 Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Higher alcohols (>3 carbons) and related compounds/5.Fire-fighting measures 5.1 Extinguishing media Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.5.2 Specific hazards arising from the chemical
Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.6.Accidental release measures 6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.6.2 Environmental precautions
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Wash away remainder with plenty of water.6.3 Methods and materials for containment and cleaning up
1. Remove all ignition sources. 2. Ventilate area of spill or leak. For small quantities, absorb on paper towels. Evaporate in safe place ... allow sufficient time for evaporating vapors to completely clear hood ductwork. Burn paper in suitable location away from combustible materials. Large quantities can be collected & atomized in suitable combustion chamber.7.Handling and storage 7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 18.104.22.168 Conditions for safe storage, including any incompatibilities
Fireproof. Separated from strong oxidants and aluminium.Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carfully resealed and kept upright to prevent leakage.8.Exposure controls/personal protection 8.1 Control parameters Occupational Exposure limit values
Recommended Exposure Limit: 10 Hour Time-Weighted Average: 50 ppm (150 mg/cu m).Biological limit values
no data available8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.8.3 Individual protection measures, such as personal protective equipment (PPE) Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.Respiratory protection
Wear dust mask when handling large quantities.Thermal hazards
no data available9.Physical and chemical properties
|Physical state||Colorless liquid and has a characteristic odor|
|Colour||Colorless, oily liquid|
|Odour||Sweet, musty odor|
|Melting point/ freezing point||-108ºC|
|Boiling point or initial boiling point and boiling range||108°C(lit.)|
|Flammability||Class IC Flammable Liquid: Fl.P. at or above 22.78°C and below 37.78°C.Flammable.|
|Lower and upper explosion limit / flammability limit||no data available|
|Decomposition temperature||no data available|
|pH||no data available|
|Kinematic viscosity||4.0 mPa.s at 20°C|
|Solubility||In water:95 g/L (20 ºC)|
|Partition coefficient n-octanol/water (log value)||log Kow = 0.76|
|Vapour pressure||8 mm Hg ( 20 °C)|
|Density and/or relative density||0.803g/mLat 25°C(lit.)|
|Relative vapour density||2.55 (vs air)|
|Particle characteristics||no data available|
no data available10.2 Chemical stability
Heat /contributes to instability/10.3 Possibility of hazardous reactions
Flammable in the presence of a source of ignition when the temperature is above the flash point. Keep away from heat/sparks/open flame/ hot surface. No smoking.ISOBUTANOL is an alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides. This chemical is incompatible with strong oxidizers.10.4 Conditions to avoid
no data available10.5 Incompatible materials
Contact with strong oxidizers may cause fires & explosions.10.6 Hazardous decomposition products
When heated to decomposition it emits acrid smoke & fumes.11.Toxicological information Acute toxicity
- Oral: LD50 Rat oral 2.46 g/kg
- Inhalation: no data available
- Dermal: no data available
no data availableSerious eye damage/irritation
no data availableRespiratory or skin sensitization
no data availableGerm cell mutagenicity
no data availableCarcinogenicity
no data availableReproductive toxicity
no data availableSTOT-single exposure
no data availableSTOT-repeated exposure
no data availableAspiration hazard
no data available12.Ecological information 12.1 Toxicity
- Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill) weight 1.15 g; Conditions: freshwater, flow through, 17.6°C (15.7-19.2), pH 8.04 (7.98-8.19), hardness 196 mg/L CaCO3, alkalinity 172 mg/L CaCO3, dissolved oxygen 6.83 mg/L (5.07-7.67 mg/L); Concentration: 1600000 ug/L for 96 hr (95% confidence interval: 1480000-1730000 ug/L)
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea); Conditions: freshwater, renewal, 25°C, pH >7; Concentration: 1250000 ug/L for 24 hr; Effect: behavior, equilibrium /formulation
- Toxicity to algae: EC50; Species: Scenedesmus subspicatus (Green Algae) exponential growth phase; Conditions: freshwater, static, 24°C, pH 8.0-9.3; Concentration: 1250000 ug/L for 48 hr; Effect: population, decreased biomass /formulation
- Toxicity to microorganisms: no data available
AEROBIC: The first-order biodegradation rate constant of isobutyl alcohol using an activated sludge inoculum was reported as 1.15X10-2 hour-1(1); this corresponds to a half-life of about 2.5 days(SRC). Isobutyl alcohol, present at 100 mg/L, reached 90% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L and the Japanese MITI test which classifies the cpompound as readily biodegradable(2). The biodegradation half-life of isobutyl alcohol in a basic sandy silt loam from Texas was reported as 2.4 days and the half-life of isobutyl alcohol in an acidic sandy loam from Mississippi was reported as 11.3 days(3). Isobutyl alcohol reached 63% of its theoretical BOD using a sewage sludge during a 5 day incubation period(4). In a river die-away test, isobutyl alcohol achieved 58% of its theoretical BOD in 5 days(5), suggesting biodegradation will be an important fate process. OECD 301D Closed Bottle test yielded 14% degradation at day 5, 74% degradation at day 15 and 74% degradation at day 28(6). A second OECD 301D Closed Bottle test yielded 55% degradation on day 5, 73% degradation on day 15, and 75% degradation on day 30(6). The potential for biodegradation in a simulated wastewater treatment plant was examined using the OECD method 303A Coupled Units Test(6); over the course of 35 days, the DOC reduction averaged 97% suggesting that isobutyl alcohol is easily degraded in wastewater treatment plants(6).12.3 Bioaccumulative potential
An estimated BCF of 3 was calculated in fish for isobutyl alcohol(SRC), using a log Kow of 0.76(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).12.4 Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc of isobutyl alcohol can be estimated to be 2.9(SRC). According to a classification scheme(2), this estimated Koc value suggests that isobutyl alcohol is expected to have very high mobility in soil.12.5 Other adverse effects
no data available13.Disposal considerations 13.1 Disposal methods Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.14.Transport information 14.1 UN Number
|ADR/RID: UN1212||IMDG: UN1212||IATA: UN1212|
|ADR/RID: ISOBUTANOL (ISOBUTYL ALCOHOL)|
|IMDG: ISOBUTANOL (ISOBUTYL ALCOHOL)|
|IATA: ISOBUTANOL (ISOBUTYL ALCOHOL)|
|ADR/RID: 3||IMDG: 3||IATA: 3|
|ADR/RID: III||IMDG: III||IATA: III|
|ADR/RID: no||IMDG: no||IATA: no|
no data available14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available15.Regulatory information 15.1 Safety, health and environmental regulations specific for the product in question
|Chemical name||Common names and synonyms||CAS number||EC number|
|European Inventory of Existing Commercial Chemical Substances (EINECS)||Listed.|
|United States Toxic Substances Control Act (TSCA) Inventory||Listed.|
|China Catalog of Hazardous chemicals 2015||Listed.|
|New Zealand Inventory of Chemicals (NZIoC)||Listed.|
|Philippines Inventory of Chemicals and Chemical Substances (PICCS)||Listed.|
|Vietnam National Chemical Inventory||Listed.|
|Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)||Listed.|
|Creation Date||Aug 17, 2017|
|Revision Date||Aug 17, 2017|
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/