| Product name | maleic hydrazide |
|---|
| Product number | - |
|---|---|
| Other names | 1,2,3,6-tetrahydro-3,6-dioxopyridazine |
| Identified uses | For industry use only. |
|---|---|
| Uses advised against | no data available |
| Company | MOLBASE (Shanghai) Biotechnology Co., Ltd. |
|---|---|
| Address | Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, Xuhui District, Shanghai, China |
| Telephone | +86(21)64956998 |
| Fax | +86(21)54365166 |
| Emergency phone number | +86-400-6021-666 |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
Not classified.
2.2 GHS label elements, including precautionary statements| Pictogram(s) | No symbol. |
|---|---|
| Signal word | No signal word. |
| Hazard statement(s) | none |
| Precautionary statement(s) | |
| Prevention | none |
| Response | none |
| Storage | none |
| Disposal | none |
none
3.Composition/information on ingredients 3.1 Substances| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| maleic hydrazide | maleic hydrazide | 123-33-1 | none | 100% |
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaledIf breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contactWash off with soap and plenty of water. Consult a physician.
In case of eye contactRinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowedNever give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2 Most important symptoms/effects, acute and delayedInhalation of dust causes irritation of nose and throat. Contact with eyes or skin causes irritation. Ingestion has been observed to cause tremors and muscle spasms in test animals. (USCG, 1999)
4.3 Indication of immediate medical attention and special treatment needed, if necessaryBasic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry, sterile dressings after decontamination ... . /Hydrazine and Related Compounds/
5.Fire-fighting measures 5.1 Extinguishing media Suitable extinguishing mediaExtinguish with water, dry chemicals, foam or carbon dioxide.
5.2 Specific hazards arising from the chemicalSpecial Hazards of Combustion Products: Toxic nitrogen oxides are produced. (USCG, 1999)
5.3 Special protective actions for fire-fightersWear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures 6.1 Personal precautions, protective equipment and emergency proceduresUse personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautionsPrevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
6.3 Methods and materials for containment and cleaning upVentilate area of spill or leak. Collect for reclamation, or absorb in vermiculite, dry sand, earth, or a similar material.
7.Handling and storage 7.1 Precautions for safe handlingAvoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilitiesDe-Cut, Fair Plus, Super De-sprout have indefinite shelf life and should be stored at room temp.
8.Exposure controls/personal protection 8.1 Control parameters Occupational Exposure limit valuesno data available
Biological limit valuesno data available
8.2 Appropriate engineering controlsHandle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE) Eye/face protectionSafety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protectionWear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protectionWear dust mask when handling large quantities.
Thermal hazardsno data available
9.Physical and chemical properties| Physical state | white cystals |
|---|---|
| Colour | Crystals from water |
| Odour | Odorless |
| Melting point/ freezing point | 142°C(lit.) |
| Boiling point or initial boiling point and boiling range | 123°C/10mmHg(lit.) |
| Flammability | no data available |
| Lower and upper explosion limit / flammability limit | no data available |
| Flash point | 300°C |
| Auto-ignition temperature | 375°C |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | In water:6 g/L |
| Partition coefficient n-octanol/water (log value) | log Kow= -0.68 pH = 5; -1.96 at pH = 7; -2.41 at pH = 9 |
| Vapour pressure | 0.289mmHg at 25°C |
| Density and/or relative density | 1.6 |
| Relative vapour density | no data available |
| Particle characteristics | no data available |
no data available
10.2 Chemical stabilityVery stable to both acidic & basic hydrolysis.
10.3 Possibility of hazardous reactionsMALEIC HYDRAZIDE can be decomposed by oxidizing agents. It can also be decomposed by strong acids. It forms water-soluble alkali-metal and amine salts. It is slightly acidic and may be titrated as a monobasic acid. Mild oxidation produces a compound which reacts instantly with dienes at -41.67°C to form crystalline derivatives. This chemical is slightly corrosive to iron and zinc. It is incompatible with pesticides that are highly alkaline in reaction. In the presence of heavy metal and iron, zinc, calcium and magnesium ions, sparingly-soluble salts are formed.
10.4 Conditions to avoidno data available
10.5 Incompatible materialsIf in presence of strong acid, maleic hydrazide acid may precipitate. Do not use concentrate through brass nozzles as the amine content may cause erosion.
10.6 Hazardous decomposition productsWhen heated to decomposition it emits highly toxic fumes of /nitrogen oxides/.
11.Toxicological information Acute toxicity- Oral: LD50 Rat oral >5000 mg/kg
- Inhalation: LC50 Rat inhalation >20 mg/L/1 hr
- Dermal: LD50 Rabbit percutaneous >5000 mg/kg
no data available
Serious eye damage/irritationno data available
Respiratory or skin sensitizationno data available
Germ cell mutagenicityno data available
CarcinogenicityCancer Classification: Group E Evidence of Non-carcinogenicity for Humans
Reproductive toxicityno data available
STOT-single exposureno data available
STOT-repeated exposureno data available
Aspiration hazardno data available
12.Ecological information 12.1 Toxicity- Toxicity to fish: LC50 Lepomis macrochirus (Bluegill) 1608 mg/L/96 hr /Conditions of bioassay not specified
- Toxicity to daphnia and other aquatic invertebrates: LC50 Daphnia magna 107.5 ppm /Technical maleic hydrazide, 90% ai
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
... MALEIC HYDRAZIDE CAN SERVE AS SOLE SOURCE OF CARBON & NITROGEN FOR NUMBER OF MICROORGANISMS & ... IS VERY SUBJECT TO BACTERIAL DECOMP IN SOIL ... .
12.3 Bioaccumulative potentialAn estimated BCF of 3 was calculated for maleic hydrazide(SRC), using a log Kow of -1.96 (1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soilThe reported Koc of maleic hydrazide was 264 for a clay soil, and 23 for a sand(1). Based on a classification scheme(2), these Koc values suggest that maleic hydrazide has very high to moderate mobility in soil(SRC). In a field experiment in which 5 and 10 kg/ha of maleic hydrazide were applied, the hydrazide did not migrate below a depth of 10 cm(3). This may be due to extensive biodegradation of maleic hydrazide(3). Maleic hydrazide was shown to bind to the clay component in Aiken clay loam where anion exchange is the predominant process(4). In a study of the adsorption of maleic hydrazide in 22 different soils, adsorption was most significantly correlated to specific surface area, clay content, and pH(5). The lack of correlation of adsorption with organic content of the soils may have been partly caused by the low organic content of the soils studied (<2%)(5). Adsorption of the herbicide ranged from high to low(5). Based upon the above information, maleic hydrazide may generally be expected to be mobile in soils with low clay content and relatively immobile in soils with high clay content. The mobility also may be affected by pH and specific surface area of the soils(SRC).
12.5 Other adverse effectsno data available
13.Disposal considerations 13.1 Disposal methods ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packagingContainers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information 14.1 UN Number| ADR/RID: UN3428 | IMDG: UN3428 | IATA: UN3428 |
| ADR/RID: 3-CHLORO-4-METHYLPHENYL ISOCYANATE, SOLID |
| IMDG: 3-CHLORO-4-METHYLPHENYL ISOCYANATE, SOLID |
| IATA: 3-CHLORO-4-METHYLPHENYL ISOCYANATE, SOLID |
| ADR/RID: 6.1 | IMDG: 6.1 | IATA: 6.1 |
| ADR/RID: II | IMDG: II | IATA: II |
| ADR/RID: no | IMDG: no | IATA: no |
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Codeno data available
15.Regulatory information 15.1 Safety, health and environmental regulations specific for the product in question| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| maleic hydrazide | maleic hydrazide | 123-33-1 | none |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Not Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Creation Date | Aug 10, 2017 |
|---|---|
| Revision Date | Aug 10, 2017 |
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
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