| Product name | 1-Chloro-3-nitrobenzene |
|---|
| Product number | - |
|---|---|
| Other names | Benzene, 1-chloro-3-nitro- |
| Identified uses | For industry use only. |
|---|---|
| Uses advised against | no data available |
| Company | MOLBASE (Shanghai) Biotechnology Co., Ltd. |
|---|---|
| Address | Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, Xuhui District, Shanghai, China |
| Telephone | +86(21)64956998 |
| Fax | +86(21)54365166 |
| Emergency phone number | +86-400-6021-666 |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
Acute toxicity - Oral, Category 3
Acute toxicity - Dermal, Category 3
Skin sensitization, Category 1
Acute toxicity - Inhalation, Category 3
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
2.2 GHS label elements, including precautionary statements| Pictogram(s) |    |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H301 Toxic if swallowed H311 Toxic in contact with skin H317 May cause an allergic skin reaction H331 Toxic if inhaled H411 Toxic to aquatic life with long lasting effects |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. |
| Response | P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/… P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P312 Call a POISON CENTER/doctor/…if you feel unwell. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P333+P313 If skin irritation or rash occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P311 Call a POISON CENTER/doctor/… P391 Collect spillage. |
| Storage | P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed. |
| Disposal | P501 Dispose of contents/container to ... |
none
3.Composition/information on ingredients 3.1 Substances| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 1-Chloro-3-nitrobenzene | 1-Chloro-3-nitrobenzene | 121-73-3 | none | 100% |
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaledFresh air, rest. Refer for medical attention. See Notes.
In case of skin contactRemove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
In case of eye contactRinse with plenty of water for several minutes (remove contact lenses if easily possible).
If swallowedRinse mouth. Refer immediately for medical attention.
4.2 Most important symptoms/effects, acute and delayedSYMPTOMS: Symptoms of exposure to this compound may include cyanosis from methemoglobinemia; and blood changes. ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes.
4.3 Indication of immediate medical attention and special treatment needed, if necessary/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Aromatic hydrocarbons and related compounds/
5.Fire-fighting measures 5.1 Extinguishing media Suitable extinguishing mediaWater may cause foaming or frothing. Use water spray, dry chemical, foam, or carbon dioxide. /Chloronitrobenzenes/
5.2 Specific hazards arising from the chemicalFlash point data for this chemical are not available. It is probably combustible.
5.3 Special protective actions for fire-fightersWear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures 6.1 Personal precautions, protective equipment and emergency proceduresUse personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautionsDo NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning upEnvironmental considerations-land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water. Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents. /Chloronitrobenzenes, meta, solid/
7.Handling and storage 7.1 Precautions for safe handlingAvoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilitiesSeparated from combustible substances, reducing agents and food and feedstuffs. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.Store in a cool, dry, well ventilated location. Separate from alkalies and oxidizing materials. /Chloronitrobenzenes/
8.Exposure controls/personal protection 8.1 Control parameters Occupational Exposure limit valuesno data available
Biological limit valuesno data available
8.2 Appropriate engineering controlsHandle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE) Eye/face protectionSafety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protectionWear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protectionWear dust mask when handling large quantities.
Thermal hazardsno data available
9.Physical and chemical properties| Physical state | Moist tan or pale yellow crystalline solid |
|---|---|
| Colour | Pale-yellow orthorhombic prisms from alcohol |
| Odour | no data available |
| Melting point/ freezing point | 188°C(lit.) |
| Boiling point or initial boiling point and boiling range | 236°C(lit.) |
| Flammability | Combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
| Lower and upper explosion limit / flammability limit | Lower flammable limit: 1.4% by volume; Upper flammable limit: 8.7% by volume |
| Flash point | 107°C(lit.) |
| Auto-ignition temperature | 500 deg F (260°C) |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | In water:INSOLUBLE |
| Partition coefficient n-octanol/water (log value) | log Kow = 2.41 |
| Vapour pressure | 0.0744mmHg at 25°C |
| Density and/or relative density | 1.534 |
| Relative vapour density | (air = 1): 5.44 |
| Particle characteristics | no data available |
no data available
10.2 Chemical stabilityStable under recommended storage conditions.
10.3 Possibility of hazardous reactionsDust explosion possible if in powder or granular form, mixed with air.3-CHLORONITROBENZENE can react with oxidizing materials. .
10.4 Conditions to avoidno data available
10.5 Incompatible materialsReacts with alkalies, oxidizing materials. /Chloronitrobenzenes/
10.6 Hazardous decomposition productsno data available
11.Toxicological information Acute toxicity- Oral: LD50 Mouse oral 390 mg/kg bw
- Inhalation: no data available
- Dermal: no data available
no data available
Serious eye damage/irritationno data available
Respiratory or skin sensitizationno data available
Germ cell mutagenicityno data available
CarcinogenicityEvaluation: There is inadequate evidence in humans for the carcinogenicity of chloronitrobenzenes. There is inadequate evidence in experimental animals for the carcinogenicity of chloronitrobenzenes. Overall evaluation: Chloronitrobenzenes are not classifiable as to their carcinogenicity to humans (Group 3). /Chloronitrobenzenes/
Reproductive toxicityno data available
STOT-single exposureno data available
STOT-repeated exposureno data available
Aspiration hazardno data available
12.Ecological information 12.1 Toxicity- Toxicity to fish: LC50; Species: Danio rerio (Zebra danio, <4 hr old); Conditions: freshwater, static, 25°C, pH 8.2, hardness 250 mg/L CaCO3; Concentration: 56000 ug/L for 7 days (95% confidence interval: 32000-100000 ug/L) />98% purity
- Toxicity to daphnia and other aquatic invertebrates: EC50 Daphnia magna 26 mg/L for 48 hr. /Conditions of bioassay not specified in source examined
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
AEROBIC: 1-Chloro-3-nitrobenzene was tested for biodegradability using the OECD, river die-away, and Pitter tests; the half-life for 1-chloro-3-nitrobenzene was much greater than four weeks for these tests using both unadapted and adapted inoculum(1). A lack of significant ring cleavage by day 64, as measured by UV spectroscopy, showed that 1-chloro-3-nitrobenzene at 10 ug/mL did not degrade readily in aqueous suspensions of Niagara silt loam(2). This analytical method was not selective enough however, to determine whether biotransformations not involving aromatic ring cleavage may have taken place(2). Information from studies to determine the effectiveness of various drinking water purification methods in the Netherlands suggests that 1-chloro-3-nitrobenzene may be biodegraded in soil(3). The removal of 1-chloro-3-nitrobenzene from bank-filtered water that was observed in these studies, may have been due partly to biodegradation; however, the contribution of other processes such as adsorption was not determined. In an earlier study, 1-chloro-3-nitrobenzene was measured in bank-filtered Rhine River water retained for a time of >1 year(4). The biodegradation half-life of 1-chloro-3-nitrobenzene was >64 days in solutions using microorganisms derived from a soil inoculum(5).
12.3 Bioaccumulative potentialRainbow trout (Salmo gairdneri) were fed a mixture of 14 different chloronitrobenzenes, including 1-chloro-3-nitrobenzene, and the amount of 1-chloro-3-nitrobenzene present in the fish was measured over 36 days(1). 1-Chloro-3-nitrobenzene was present in trace amounts 3 days following exposure and was not detectable (<5 ug/kg fish) after 8 days. Fish in water containing 800 ng/L of 1-chloro-3-nitrobenzene plus the same mixture of chloronitrobenzenes had BCF values for 1-chloro-3-nitrobenzene of 77 after 5 days to 91 after 36 days with a mean BCF of 78(1). According to a classification scheme(2), these BCF values suggest bioconcentration in aquatic organisms is moderate(SRC).
12.4 Mobility in soilUsing a structure estimation method based on molecular connectivity indices(1), the Koc of 1-chloro-3-nitrobenzene can be estimated to be 310(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1-chloro-3-nitrobenzene is expected to have moderate mobility in soil(SRC).
12.5 Other adverse effectsno data available
13.Disposal considerations 13.1 Disposal methods ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packagingContainers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information 14.1 UN Number| ADR/RID: UN1578 | IMDG: UN1578 | IATA: UN1578 |
| ADR/RID: CHLORONITROBENZENES, SOLID |
| IMDG: CHLORONITROBENZENES, SOLID |
| IATA: CHLORONITROBENZENES, SOLID |
| ADR/RID: 6.1 | IMDG: 6.1 | IATA: 6.1 |
| ADR/RID: II | IMDG: II | IATA: II |
| ADR/RID: yes | IMDG: yes | IATA: yes |
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Codeno data available
15.Regulatory information 15.1 Safety, health and environmental regulations specific for the product in question| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| 1-Chloro-3-nitrobenzene | 1-Chloro-3-nitrobenzene | 121-73-3 | none |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Not Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Creation Date | Aug 10, 2017 |
|---|---|
| Revision Date | Aug 10, 2017 |
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
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