734-32-7 甲基双酮

甲基双酮

英文名称:Norandrostenedione
CAS:

734-32-7

分子式:C18H24O2
  • 化合物简介
  • 基本信息
  • 编号系统
  • 物化性质
  • 安全信息
  • 合成路线
  • MSDS
  • 图谱
  • 上游原料
  • 下游产品

甲基双酮简介

Bolandione, also known as 19-norandrostenedione (19-norandrost-4-en-3,17-dione), is a precursor of the anabolic steroid nandrolone. Until 2005, bolandione was available without prescription in United States, where it was marketed as a prohormone, but it is now classified as a Schedule III drug. It is also banned from use in many sports, including the Olympic Games, under the World Anti-Doping Code. Bolandione is readily metabolized to nandrolone after oral administration, but its potency to transactivate the androgen receptor dependent reporter gene expression is 10 times lower as compared to dihydrotestosterone (DHT).
Scientific studies have shown that oral administration of bolandione is "a very ineffective strategy for stimulating skeletal muscle mass increases but may be associated with side effects".
In vivo experiments in castrated rats demonstrated that subcutaneous treatment with bolandione resulted only in a stimulation of the weight of the levator ani muscle, while the prostate and seminal vesicle weights remained completely unaffected. In contrast to its metabolite nandrolone, bolandione highly selectively stimulates the growth of the skeletal muscles but has only weak androgenic properties.
In the early 2000s, contamination of androstenedione products with traces of bolandione caused false positives for doping tests for nandrolone because 19-norandrosterone is a metabolite of both nandrolone and bolandione. In a randomized controlled trial trace contamination of androstenedione with bolandione was sufficient for users of androstenedione to test positive for nandrolone. This detail became less relevant after bolandione and androstenedione were banned by major sporting bodies.

甲基双酮基本信息

中文名称 甲基双酮 英文名称 Norandrostenedione
中文别名

甲基固烯双酮; 19-去甲-4-雄烯二酮; 雌甾-4-烯-3,17-二酮; 19-去甲雄甾-4-烯-3,17-二酮; 雌二醇杂质; 19-去甲雄烯二酮;

查看更多中文别名
英文别名

19-NORANDROSTENDIONE; 19-nor-androst-4-ene-3,17-dione; 19-NORANDROSTENEDIONE; 4-ESTRENE-3,17-DIONE; 19-Norandrost-4-ene-3,17-dione; 4-ESTREN-3,17-DIONE; 19-nor-4-androstene-3; Estr-4-ene-3,17-dione; Nor-4-Androstenedione; 19-nor-4-androstene-3,17-dione; dl-19-norandrost-4-ene-3,17-dione; 19-nor-4-androstenedione;

查看更多英文别名
CAS号 734-32-7 分子式 C18H24O2
分子量 272.38200 精确质量 272.17800
PSA 34.14000 LOGP 3.69730

甲基双酮编号系统

UNII U90987PVU5

甲基双酮物化性质

密度:
1.106 g/mL at 25 °C(lit.)
沸点:
63-66 °C10 mm Hg(lit.)
熔点:
−72 °C(lit.)
闪点:
80 °F
折射率:
n20/D 1.457(lit.)
水溶解性:
insoluble
储存条件:
Refrigerator

安全信息

安全说明:
S16; S26; S36/37/39; S45
危险类别码:
R11
WGK Germany:
3
危险品标志:
F; C
SDS 1.0 中文 展开
SDS 1.0 英文 展开
MSDS 中文 展开
1H NMR : Predict展开

核磁图谱 1H NMR : Predict

收起
查看更多
快捷导航
生物及医药化学品 医药中间体
上游原料
2-Trimethylsilyl-1-(4-methoxy-2-methylphenyl)-2-propen-1-on 2,4-二溴雌酮 (1Ξ,5SR)-1-Methyl-2-oxo-5-vinylcyclopentan-1,3-dicarbonsaeure-dimethylester 10β-bromo-5α-hydroxyestra-3,17-dione bis(ethylene ketal) [(1SR,2Ξ)-2-Methyl-3-oxocyclopentyl]essigsaeure-methylester 5α-hydroxy-10β-mercaptoestra-3,17-dione bis(ethylene ketal) 19-羧基雄甾-4-烯-3,17-二酮 (3R,5R,8R,9R,10S,13S,14S,17S)-13-methyl-1,2,3,4,5,6,7,8,9,10,11,12,14,15,16,17-hexadecahydrocyclopenta[a]phenanthrene-3,17-diol Androst-5-en-3,17-dion-19-saeure 3α,17β-dihydroxy-3β-methylestra-4-ene 19-去甲基-5(10)-雄烯二酮 19-羟基-4-雄甾烯-3,17-二酮 19-nor-5β-androstane-3,17-dione 3-(5'-methyl-2'-furyl)propanoic acid chloride 2-Furanacetyl chloride, 5-ethyl- 5α,10α-Oxido-3,17-bis-ethylendioxy-19-nor-androstan 4-(5'-methyl-2'-furyl)butanoic acid chloride 2-Furanacetyl chloride, 5-methyl- (17B)-3-甲氧基雌甾-2,5(10)-二烯-17-醇 [(6ω,7S)-6-Methyl-1,4-dioxaspiro[4,4]non-7-yl]essigsaeure-methylester 3-(5'-methyl-2'-furyl)propanoic acid 2-[(6ω,7S)-6-Methyl-1,4-dioxaspiro[4,4]non-7-yl]ethanol 炔诺酮 苯海拉明 3-(5'-ethyl-2'-furyl)propanoic acid chloride 诺龙 10β-hydroxy-5ξ-estrane-3,17-dione (2Ξ,3SR)-2-Methyl-3-vinylcyclopentan-1-on 3,17-Dioxo-19-nor-androsten-(5(10))-bis-aethylenketal (+)-3,3-ethylenedioxy-4,5-seco-19-norandrost-9-en-5,17-dione
下游产品
5-蒽基肼 炔诺酮 2-羟基雌酚酮 甲基诺龙 炔诺醇 乙诺酮 3-羟基-雌甾-1,3,5(10),6-四烯-17-酮 4,6-雌甾二烯-3,17-二酮 雌甾-3,17-二酮 4-羟雌二醇 4-羟雌甾酮 estr-4-ene-3,6,17-trione 诺龙 6-酮雌酚酮 3-O-methylestra-1,3,5(10)-trien-3-ol-6,17-dione 3-甲氧基雌酮 雌酚酮
上游原料厂家
炔诺酮厂家 19-羟基-4-雄甾烯-3,17-二酮厂家 (17B)-3-甲氧基雌甾-2,5(10)-二烯-17-醇厂家 19-羧基雄甾-4-烯-3,17-二酮厂家 苯海拉明厂家
下游原料厂家
6-酮雌酚酮厂家 炔诺酮厂家 4-羟雌甾酮厂家 3-甲氧基雌酮厂家 4-羟雌二醇厂家 炔诺醇厂家 雌酚酮厂家 3-羟基-雌甾-1,3,5(10),6-四烯-17-酮厂家 雌甾-3,17-二酮厂家 2-羟基雌酚酮厂家
上游原料批发
炔诺酮 19-羟基-4-雄甾烯-3,17-二酮 (17B)-3-甲氧基雌甾-2,5(10)-二烯-17-醇 19-羧基雄甾-4-烯-3,17-二酮 苯海拉明
下游原料批发
6-酮雌酚酮 炔诺酮 4-羟雌甾酮 3-甲氧基雌酮 4-羟雌二醇 炔诺醇 雌酚酮 3-羟基-雌甾-1,3,5(10),6-四烯-17-酮 雌甾-3,17-二酮 2-羟基雌酚酮
甲基双酮
CAS号:734-32-7 分子式:C18H24O2 分子量:272.38200

化工圈APP

二维码

微信公众号

二维码

购物车

不要让您的购物车空着哦,买试剂买原料
如果您已添加过宝贝,那就赶紧登录查看吧

投诉建议

  • 咨询类别
  • 问题描述
  • 联系人电话
  • 联系人