首页 > 化工百科 > 生物及医药化学品 > 药物杂质 > 戊酸雌二醇

戊酸雌二醇

英文名称: Estradiol 17-Valerate

CAS号:

979-32-8

分子式:C23H32O3 分子量:356.49800
摩贝参考价:
¥41666.00 / kg 我要报价

关于参考价
摩贝参考价是根据供应商的报价结合成交价,通过一定
算法规则计算出的报价,仅供数据参考,该价格每个月
会进行一轮更新。

戊酸雌二醇简介

Estradiol valerate (EV, E2V) (INN, USAN, JAN) (brand names Altadiol, Deladiol, Delestrogen, Estraval, Lastrogen, Progynova, Valergen, many others), or oestradiol valerate (BAN), is a synthetic ester, specifically the 17-pentanoyl ester, of the natural estrogen, 17β-estradiol. It was first introduced, as Delestrogen by Squibb in the United States, in 1954, and along with estradiol benzoate (1936) and estradiol cypionate (1952), has since become one of the most widely used esters of estradiol.
Upon ingestion, regardless of the route of administration, estradiol valerate behaves as a prodrug, being cleaved by esterases in blood plasma and the liver into 17β-estradiol and valeric acid. However, compared to estradiol itself, estradiol valerate is absorbed more slowly and possesses a longer duration, especially when given in an oil solution via intramuscular injection (in which it acts as a depot). As a result, it can be administered less frequently.
A single intramuscular injection of 4mg estradiol valerate results in maximal plasma levels of estradiol of about 390 pg/mL within three days of administration, with levels declining to 100 pg/mL by 12–13 days. A study of high-dose combined administration of 40mg estradiol valerate and 250mg hydroxyprogesterone caproate in women once weekly for six months (described as a "pseudopregnancy" regimen) found that serum levels of estradiol increased from 27.8–34.8 pg/mL to 3028–3226 pg/mL after three months and to 2491–2552 pg/mL after six months of treatment.

戊酸雌二醇基本信息

中文名称 戊酸雌二醇 英文名称 Estradiol 17-Valerate
中文别名

17-戊酸-Beta-雌二醇酯; 17-戊酸-β-雌二醇酯; 3,5(10)-三烯-17B-醇 17-戊酸酯; 17-戊酸-17-BETA-雌二酯; 3-羟基雌甾-1,3,5(10)-三烯-17b-醇 17-戊酸酯;

查看更多中文别名
英文别名

Estradiol valerate;

查看更多英文别名
CAS号 979-32-8 分子式 C23H32O3
分子量 356.49800 精确质量 356.23500
PSA 46.53000 LOGP 5.35030

戊酸雌二醇编号系统

UNII OKG364O896

戊酸雌二醇物化性质

密度:
1.13g/cm3
沸点:
486.2ºC at 760mmHg
熔点:
144°C
闪点:
191.1ºC
折射率:
1.567

安全信息

RTECS号:
KG5793000
安全说明:
S53-S45
危险类别码:
R60; R61
WGK Germany:
3
危险品标志:
T

生产方法及用途

用途

用于治疗闭经、更年期综合症、减少乳汁分泌、前列腺癌等。

SDS 1.0 中文 展开
SDS 1.0 英文 展开
1H NMR : Predict展开

核磁图谱 1H NMR : Predict

收起
您可能感兴趣的化合物
快捷导航
生物及医药化学品 药物杂质
上游原料
3-benzoyloxy-17β-valeryloxy-estra-1,3,5(10)-triene 雌二醇3,17-二戊酸酯 雌二醇 戊酰氯 缬草酸
戊酸雌二醇
CAS号:979-32-8 分子式:C23H32O3 分子量:356.49800

化工圈APP

二维码

微信公众号

二维码

购物车

不要让您的购物车空着哦,买试剂买原料
如果您已添加过宝贝,那就赶紧登录查看吧

摩贝客服

试剂业务咨询

400-6021-666 转 2
立即咨询

综合业务咨询

400-6021-666
立即咨询

粉末涂料咨询

400-6021-666
立即咨询

投诉建议

  • 咨询类别
  • 问题描述
  • 联系人电话
  • 联系人