113507-06-5 莫西菌素

莫西菌素

英文名称:moxidectin
CAS:

113507-06-5

分子式:C37H53NO8
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莫西菌素简介

Moxidectin (Milbemycin B) is an anthelmintic drug which kills parasitic worms (helminths), and is used for the prevention and control of heartworm and intestinal worms. It can be found in treatments prescribed for animals such as dogs, cats, horses, cattle and sheep. Application methods for moxidectin vary by treatment, and include oral, topical, and injectable solutions. Cydectin Pour On is a trade name for a formulation for use on cattle and red deer.
Moxidectin is a semisynthetic derivative of nemadectin which is produced by fermentation by Streptomyces cyano-griseus. This Streptomyces species was discovered in a soil sample from Australia in the late 1980s collected by an agronomist working for the American Cyanamid company.
Moxidectin treats and controls some of the most common internal and external parasites by selectively binding to a parasite's glutamate-gated chloride ion channels. These channels are vital to the function of invertebrate nerve and muscle cells; when moxidectin binds to the channels, it disrupts neurotransmission, resulting in paralysis and death of the parasite.
Studies of moxidectin show the side effects vary by animal and may be affected by the product’s formulation, application method and dosage. The products are usually recommended by a veterinarian to ensure correct use and application. Herding dogs may be avermectin-sensitive, but avermectin-sensitive dogs can tolerate standard doses for heartworm prevention. Moxidectin is apparently safe for collie breeds. As a heartworm preventative, moxidectin can be injected once every six months under the brand name Proheart6, or every 12 months under the brand name Proheart SR 12.
Moxidectin is the subject of a trial to assess its suitability, as an alternative to ivermectin, to treat onchocerciasis in humans.

莫西菌素基本信息

中文名称 莫西菌素 英文名称 moxidectin
中文别名

莫西克汀; 莫西丁克; 莫昔克丁;

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英文别名

Equest; Vetdectin Oral Drench; proheart; bridged fused ring systems nomenclature: (2aE,4E,8E)-(5’S,6R,6’S,11R,13R,15S,17aR,20R,20aR,20bS)-6’-[(1E)-1,3-dimethylbut-1-enyl]-5’,6’,10,11,14,15,17a,20,20a,20b-decahydro-20,20b-dihydroxy-5’,6,8,19-tetramethylspiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2’-[2H]pyran]-4’,17(3’H,6H)-dione 4’-(E)-(O-methyloxime); ProHeart 6; Moxidectin HOUSE STANDARD; Moxidectin; (6R,23E,25S)-5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-butenyl]-6,28-epoxy-23-(methoxyimino)milbemycin B; Quest; extended von Baeyer nomenclature: (10E,14E,16E)-(1R,4S,5’S,6R,6’S,8R,13R,20R,21R,24S)-6’-[(1E)-1,3-dimethylbut-1-enyl]-21,24-dihydroxy-5’,11,13,22-tetramethyl-(3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene)-6-spiro-2’-(tetrahydropyran)-2,4’-dione 4’-(E)-(O-methyloxime);

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CAS号 113507-06-5 分子式 C37H53NO8
分子量 639.81900 精确质量 639.37700
PSA 116.04000 LOGP 5.72890

莫西菌素编号系统

UNII NGU5H31YO9

莫西菌素物化性质

密度:
1.23 g/cm3
沸点:
790ºC at 760 mmHg
闪点:
431.6ºC
折射率:
1.581
储存条件:
2-8ºC

安全信息

危险品运输编码:
UN 2588
危险类别:
6.1(b)
包装等级:
III

生产方法及用途

用途

抗寄生虫药。

SDS 1.0 中文 展开
SDS 1.0 英文 展开
1H NMR : Predict展开

核磁图谱 1H NMR : Predict

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莫西菌素
CAS号:113507-06-5 分子式:C37H53NO8 分子量:639.81900

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