首页 > 化工百科 > 其他 > 化学试剂 > 芳香化合物 > 脯氨酰-甘氨酰-脯氨酰-肾上腺皮质激素 (4-7)
80714-61-0 脯氨酰-甘氨酰-脯氨酰-肾上腺皮质激素 (4-7)

脯氨酰-甘氨酰-脯氨酰-肾上腺皮质激素 (4-7)

英文名称:L-Methionyl-L-α-glutamylhistidyl-L-phenylalanyl-L-prolylglycyl-L- proline
CAS:

80714-61-0

分子式:C37H51N9O10S
  • 化合物简介
  • 基本信息
  • 编号系统
  • 物化性质
  • MSDS
  • 图谱

脯氨酰-甘氨酰-脯氨酰-肾上腺皮质激素 (4-7)简介

Semax is a drug produced and prescribed mostly in Russia and Ukraine for a broad range of conditions but predominantly for its purported nootropic, neuroprotective, and neurogenic/neurorestorative properties. It is a heptapeptide, synthetic analog of a fragment of adrenocorticotropic hormone (ACTH), ACTH (4-10), of the following structure: Met-Glu-His-Phe-Pro-Gly-Pro. Semax has not been evaluated by the U.S. FDA.
Semax has undergone extensive study in Russia and is on the Russian List of Vital & Essential Drugs approved by the Russian Federation government on December 7, 2011. Medical uses for Semax include treatment of stroke, transient ischemic attack, memory and cognitive disorders, peptic ulcers, optic nerve disease, and to boost the immune system.
In animals, Semax rapidly elevates the levels and expression of brain-derived neurotrophic factor (BDNF) and its signaling receptor TrkB in the hippocampus, and rapidly activates serotonergic and dopaminergic brain systems. In accordance, it has been found to produce antidepressant-like and anxiolytic-like effects, attenuate the behavioral effects of exposure to chronic stress, and potentiate the locomotor activity produced by D-amphetamine. As such, it has been suggested that Semax may be effective in the treatment of depression, as well as in attention deficit hyperactivity disorder (ADHD).
Though the exact mechanism of action of Semax is unclear, there is evidence that it may act through melanocortin receptors. Specifically, there is a report of Semax competitively antagonizing the action of the melanocortin receptor full agonist α-melanocyte-stimulating hormone (α-MSH) at the MC4 and MC5 receptors in both in vitro and in vivo experimental conditions, indicating that it may act as an antagonist or partial agonist of these receptors. Semax did not antagonize α-MSH at the MC3 receptor, though this receptor could still be a target of the drug. As for the MC1 and MC2 receptors, they were not assayed. In addition to actions at receptors, Semax, as well as a related peptide drug, Selank, have been found to inhibit enzymes involved in the degradation of enkephalins and other endogenous regulatory peptides (IC50 = 10 μM), though the clinical significance of this property is uncertain.

脯氨酰-甘氨酰-脯氨酰-肾上腺皮质激素 (4-7)基本信息

中文名称 脯氨酰-甘氨酰-脯氨酰-肾上腺皮质激素 (4-7) 英文名称 L-Methionyl-L-α-glutamylhistidyl-L-phenylalanyl-L-prolylglycyl-L- proline
中文别名

查看更多中文别名
英文别名

Lys(Z)-OBzl.TosOH; H-Met-Glu-His-Phe-Pro-Gly-Pro; TsOH*H-Lys(Z)-OBzl; Desmodur N 3390 BA; Met-Glu-His-Phe-Pro-Gly-Pro; 1,3,5-tris[6-isocyanatohexyl]-2,4,6-trioxo-s-triazine; trimeric hexamethylene diisocyanate; hexamethylene diisocyanate isocyanurate; tris(6-isocyanatohexyl) isocyanurate; 1,3,5-Tris(isocyanatohexamethylene)isocyanurate; HMDI trimer; H-MeLeu-OMe; H-Lys(Z)-OBzl*TosOH; L-2-methylleucine methyl ester;

查看更多英文别名
CAS号 80714-61-0 分子式 C37H51N9O10S
分子量 813.92000 精确质量 813.34800
PSA 325.58000 LOGP 2.71460

脯氨酰-甘氨酰-脯氨酰-肾上腺皮质激素 (4-7)编号系统

UNII I5FAL2585H

脯氨酰-甘氨酰-脯氨酰-肾上腺皮质激素 (4-7)物化性质

密度:
1.391g/cm3
沸点:
1335.2ºC at 760 mmHg
闪点:
761.3ºC
折射率:
1.617
SDS 1.0 中文 展开
SDS 1.0 英文 展开
MSDS 中文 展开
1H NMR : Predict展开

核磁图谱 1H NMR : Predict

收起
查看更多
脯氨酰-甘氨酰-脯氨酰-肾上腺皮质激素 (4-7)
CAS号:80714-61-0 分子式:C37H51N9O10S 分子量:813.92000

化工圈APP

二维码

微信公众号

二维码

购物车

不要让您的购物车空着哦,买试剂买原料
如果您已添加过宝贝,那就赶紧登录查看吧

投诉建议

  • 咨询类别
  • 问题描述
  • 联系人电话
  • 联系人