99533-80-9 K-252a

K-252a

英文名称:K-252a
CAS:

99533-80-9

分子式:C27H21N3O5
  • 化合物简介
  • 基本信息
  • 编号系统
  • 物化性质
  • 安全信息
  • 合成路线
  • MSDS
  • 图谱
  • 上游原料
  • 下游产品

K-252a简介

K252a is an alkaloid isolated from Nocardiopisis sp. soil fungi. This staurosporine analog is a highly potent cell permeable inhibitor of CaM kinase and phosphorylase kinase (IC50 = 1.8 and 1.7 nmol/L, respectively). At higher concentrations it is also an efficient inhibitor of serine/threonine protein kinases (IC50 of 10 to 30 nmol/L).
K252a is reported to promote myogenic differentiation in C2 mouse myoblasts and has been shown to block the neuronal differentiation of rat pheochromocytoma PC12 cells by inhibition of trk tyrosine kinase activity.
K252a has been reported in preclinical research as a potential treatment for psoriasis.; K252a inhibits tyrosine phosphorylation of Trk A induced by NGF. PC12 cells were incubated in the presence or absence of 10 ng/ml NGF with or without various concentrations of K252a.

K-252a基本信息

中文名称 K-252a 英文名称 K-252a
中文别名

查看更多中文别名
英文别名

antibiotick252a; PROTEIN KINASE INHIBITOR FROM NORCARDIOP SIS SP.; PROTEIN KINASE INHIBITOR K-252A; PROTEIN KINASE INHIBITOR; K252a; K-252A,NOCARDIOPSIS SP; antibioticsf2370; sf2370;

查看更多英文别名
CAS号 99533-80-9 分子式 C27H21N3O5
分子量 467.47300 精确质量 467.14800
PSA 94.72000 LOGP 3.98390

K-252a编号系统

UNII IV7H45AM5B

K-252a物化性质

密度:
1.67g/cm3
沸点:
685.3ºC at 760mmHg
闪点:
368.2ºC
折射率:
1.841
储存条件:
-20ºC

安全信息

安全说明:
S22; S24/25
危险品标志:
Xi
危险性描述:
H360D; H371
信号词:
Danger
危险性防范说明:
P201; P260; P308 + P311
危险标志:
GHS08
SDS 1.0 中文 展开
SDS 1.0 英文 展开
MSDS 中文 展开
1H NMR : Predict展开

核磁图谱 1H NMR : Predict

收起
查看更多
快捷导航
其他 化学试剂 芳香化合物
上游原料
重氮甲烷 (2S,3S,5R)-5-(7-oxo-6,7-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12(13H)-yl)-2-((phenylselanyl)methyl)tetrahydrofuran-3-yl acetate 13-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one (2R,3R)-3-Hydroxy-2,5-dimethoxy-2-methyl-tetrahydro-furan-3-carboxylic acid methyl ester 13-((2R,4S,5S)-4-hydroxy-5-((phenylselanyl)methyl)tetrahydrofuran-2-yl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one 6-N-(dimethoxybenzyl)-staurosporinone (E)-(R)-2-Acetyl-2-hydroxy-undec-4-enoic acid methyl ester K-252B (5S,6S,8R)-6-hydroxy-5-methyl-5,6,7,8,14,15-hexahydro-13H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacen-13-one 硫酸二甲酯 (5S,6S,8R)-6-cyano-5-methyl-13-oxo-5,6,7,8,14,15-hexahydro-13H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacen-6-yl acetate (5S,6S,8R)-5-methyl-13-oxo-6,7,8,13,14,15-hexahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacen-6-yl acetate 13-((2R,4S,5S)-4-hydroxy-5-(iodomethyl)tetrahydrofuran-2-yl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one (5R,6S,8R)-5-(iodomethyl)-13-oxo-6,7,8,13,14,15-hexahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacen-6-yl acetate (5S,8R)-5-methyl-7,8,14,15-tetrahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-6,13-dione (3S,5R)-2-methylene-5-(7-oxo-6,7-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12(13H)-yl)tetrahydrofuran-3-yl acetate (2R,3S,5R)-5-(6,13-diacetyl-7-oxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate
下游产品
蛋白激酶仰制剂KT5823 来他替尼
上游原料厂家
硫酸二甲酯厂家 K-252B厂家 6-N-(dimethoxybenzyl)-staurosporinone厂家
下游原料厂家
来他替尼厂家 蛋白激酶仰制剂KT5823厂家
上游原料批发
硫酸二甲酯 K-252B 6-N-(dimethoxybenzyl)-staurosporinone
下游原料批发
来他替尼 蛋白激酶仰制剂KT5823
K-252a
CAS号:99533-80-9 分子式:C27H21N3O5 分子量:467.47300

化工圈APP

二维码

微信公众号

二维码

购物车

不要让您的购物车空着哦,买试剂买原料
如果您已添加过宝贝,那就赶紧登录查看吧

投诉建议

  • 咨询类别
  • 问题描述
  • 联系人电话
  • 联系人