首页 > 化工百科 > 其他 > 化学试剂 > 卤化物 > (+)-JQ-1; (S)-(+)-2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-f][1,2,4]三唑并[4,3-a][1,4]二氮杂卓-6-基)乙酸叔丁酯
1268524-70-4 (+)-JQ-1; (S)-(+)-2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-f][1,2,4]三唑并[4,3-a][1,4]二氮杂卓-6-基)乙酸叔丁酯

(+)-JQ-1; (S)-(+)-2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-f][1,2,4]三唑并[4,3-a][1,4]二氮杂卓-6-基)乙酸叔丁酯

英文名称:(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
CAS:

1268524-70-4

分子式:C23H25ClN4O2S
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(+)-JQ-1; (S)-(+)-2-(4-(...简介

JQ1 is a thienotriazolodiazepine and a potent inhibitor of the BET family of bromodomain proteins which include BRD2, BRD3, BRD4, and the testis-specific protein BRDT in mammals. BET inhibitors structurally similar to JQ1 are being tested in clinical trials for a variety of cancers including NUT midline carcinoma. It was developed by the James Bradner laboratory at Brigham and Women's Hospital and named after chemist Jun Qi. The chemical structure was inspired by patent of similar BET inhibitors by Mitsubishi Tanabe Pharma [WO/2009/084693]. Structurally it is related to benzodiazepines. While widely used in laboratory applications, JQ1 is not itself being used in human clinical trials because it has a short half life.

(+)-JQ-1; (S)-(+)-2-(4-(...基本信息

中文名称 (+)-JQ-1; (S)-(+)-2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-f][1,2,4]三唑并[4,3-a][1,4]二氮杂卓-6-基)乙酸叔丁酯 英文名称 (S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
中文别名

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英文别名

3mxf; UNII-1MRH0IMX0W; 4flp;

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CAS号 1268524-70-4 分子式 C23H25ClN4O2S
分子量 456.98800 精确质量 456.13900
PSA 97.61000 LOGP 4.96690

(+)-JQ-1; (S)-(+)-2-(4-(...编号系统

UNII 1MRH0IMX0W
SDS 1.0 中文 展开
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1H NMR : Predict展开

核磁图谱 1H NMR : Predict

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(+)-JQ-1; (S)-(+)-2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-f][1,2,4]三唑并[4,3-a][1,4]二氮杂卓-6-基)乙酸叔丁酯
CAS号:1268524-70-4 分子式:C23H25ClN4O2S 分子量:456.98800

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