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379270-37-8 替诺福韦艾拉酚胺

替诺福韦艾拉酚胺

英文名称:Tenofovir alafenamide
CAS:

379270-37-8

分子式:C21H29N6O5P
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替诺福韦艾拉酚胺简介

Tenofovir alafenamide (INN/USAN, formerly GS-7340) is a nucleotide reverse transcriptase inhibitor and a prodrug of tenofovir. It was developed by Gilead Sciences for use in the treatment of HIV infection and chronic hepatitis B, and is applied in the form of tenofovir alafenamide fumarate (TAF). Closely related to the commonly used reverse-transcriptase inhibitor tenofovir disoproxil, TAF has greater antiviral activity and better distribution into lymphoid tissues than that agent.
Gilead announced a phase 3 clinical trial evaluating a single-tablet regimen combining tenofovir alafenamide with cobicistat, emtricitabine and elvitegravir and developed a coformulation of the drug with cobicistat, emtricitabine and the protease inhibitor darunavir. In a 48 week study comparing elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil to elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (trade name Genvoya), the results showed the newer drug to be noninferior to the established agent, but at much lower dosages and with lower incidence of adverse side effects such as impaired kidney function. The FDA approved the TAF-based treatment regimen for treatment of HIV-1 in November 2015. Genvoya is the first TAF-based regimen to receive approval.

替诺福韦艾拉酚胺基本信息

中文名称 替诺福韦艾拉酚胺 英文名称 Tenofovir alafenamide
中文别名

GS7340游离碱;

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英文别名

propan-2-yl (2S)-2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate; GS-7340; Tenofovir alafenamide free base; Sp-Tenofovir-phosphonamidate,phenyl,L-alanine isopropyl ester; TENOFOVIR ALAFENAMIDE;

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CAS号 379270-37-8 分子式 C21H29N6O5P
分子量 476.46600 精确质量 476.19400
PSA 153.29000 LOGP 3.94500

替诺福韦艾拉酚胺编号系统

UNII EL9943AG5J
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核磁图谱 1H NMR : Predict

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上游原料
泰诺福韦 亚磷酸三苯酯 D-丙氨酸异丙酯盐酸盐 L-丙氨酸异丙酯盐酸盐 phenyl ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate 苯酚
替诺福韦艾拉酚胺
CAS号:379270-37-8 分子式:C21H29N6O5P 分子量:476.46600

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