摩贝百科
诺力昂助剂 佐敦工业漆 老虎粉末涂料 原料抢购 聚合氯化铝 聚丙烯酰胺 无水氯化钙 9-氯甲基蒽
结构式
官能团
首页 > 化工百科 > 其他 > 化学试剂 > 卤化物 > 氯烯雌醚
569-57-3 氯烯雌醚

氯烯雌醚
英文名称：chlorotrianisene
CAS：

569-57-3

 分子式：C23H21ClO3
精选商品
相关知识
概览
  • 化合物简介
  • 基本信息
  • 编号系统
  • 物化性质
  • 安全信息
  • 生产方法及用途
  • 合成路线
  • MSDS
  • 图谱
  • 上游原料
  • 下游产品

氯烯雌醚简介

Chlorotrianisene (INN, USAN, BAN; brand names Tace, Estregur, Anisene, Clorotrisin, Merbentyl, Triagen, many others; also known as CTA; tri-p-anisylchloroethylene, TACE, or tris(p-methoxyphenyl)chloroethylene) is a synthetic, non-steroidal estrogen of the triphenylethylene group that was formerly used for the treatment of menopausal symptoms, estrogen deficiency, and prostate cancer before being discontinued. It was approved in the United States as TACE in 1952, and was introduced throughout Europe subsequently. CTA was the first estrogenic compound of the triphenylethylene series to be introduced.
CTA was derived from estrobin (DBE), a derivative of the very weakly estrogenic compound triphenylethylene (TPE), which in turn was derived from structural modification of diethylstilbestrol (DES). CTA is a relatively weak estrogen, with about one-eighth the potency of DES. However, it is highly lipophilic and is stored in fat tissue for prolonged periods of time, with its slow release from fat resulting in a very long duration of action. CTA itself is inactive; it behaves as a prodrug to a weak estrogen that is formed as a metabolite via degradation of CTA in the liver. As such, the potency of CTA is reduced if it is given parenterally instead of orally.
Although it is referred to as a weak estrogen and was used solely as an estrogen in clinical practice, CTA is actually a partial agonist of the estrogen receptor. As such, it is a selective estrogen receptor modulator (SERM), with predominantly estrogenic but also antiestrogenic effects, and was arguably the first SERM to ever be introduced. CTA can antagonize estradiol at the level of the hypothalamus, resulting in disinhibition of the hypothalamic-pituitary-gonadal axis and an increase in estrogen levels. Clomifene and tamoxifen were both derived from CTA via structural modification, and are much weaker partial agonists than CTA and hence much more antiestrogenic in comparison. As an example, chlorotrianisene produces gynecomastia in men, albeit reportedly to a lesser extent than other estrogens, while clomifene and tamoxifen do not and can actually be used to treat gynecomastia.

氯烯雌醚基本信息

中文名称 氯烯雌醚 英文名称 chlorotrianisene
中文别名

泰舒;

查看更多中文别名 		英文别名

2-Chlor-1,1,2-tris-(4-methoxy-phenyl)-aethylen; Chlorotrianisine; 1-[1-chloro-2,2-bis(4-methoxyphenyl)ethenyl]-4-methoxybenzene; 1-chloro-1,2,2-tris(p-methoxyphenyl)ethene; Chlorotrianisene; Merbentul; TACE; chloro-tris-(4-methoxy-phenyl)-ethene; Tris-(4-methoxy-phenyl)-vinylchlorid; 1,1',1''-(1-chloro-1-ethenyl-2-ylidene)tris[4-methoxy-benzene]; Chlor-tris-(4-methoxy-phenyl)-aethen; Chloortrianisestrol; Chlorotrianizen; Chlortrianizen; Benzene, 1,1‘,1‘‘-(1-chloro-1-ethenyl-2-ylidene)tris[4-methoxy-; Chlorestrolo; Chlortrianisestrol; Chlortrianisen;

查看更多英文别名
CAS号 569-57-3 分子式 C23H21ClO3
分子量 380.86400 精确质量 380.11800
PSA 27.69000 LOGP 5.86780

氯烯雌醚编号系统

UNII 6V5034L121

氯烯雌醚物化性质

密度：
1.168g/cm3
沸点：
514.2ºC at 760mmHg
熔点：
114-116ºC
闪点：
164.1ºC
折射率：
1.591

安全信息

RTECS号：
KV0600000
WGK Germany：
3

生产方法及用途

生产方法

有多种合成路线,由对甲氧基苯乙酮经溴化、成盐、缩合、氯化而得。总收率14.5%;也可由茴香酸出发制备,总收率44.4%,但茴香酸原料价格较贵。以茴香醚为原料,经下列步骤制取泰舒,总收率为21.6%。
1.氯代对甲氧基苯乙酮的制备 茴香醚与氯乙酰氯反应得氯代对甲氧基苯乙酮。2.1,1,2-三(对甲氧苯基)乙烯的制备 溴代茴香醚与镁制得格氏试剂,与氯代对甲氧基苯乙酮反应得油状物继续与PTS反应得1,1,2-三(对甲氧苯基)乙烯。
3.泰舒的制备 1,1,2-三(对甲氧苯基)乙烯氯化得泰舒。

用途

雌激素类药,主要用于治疗前列腺肿大和妇女更年期综合症。

查看详情 >
查看更多
SDS 1.0 中文 展开
SDS 1.0 英文 展开
1H NMR : Predict展开

核磁图谱 1H NMR : Predict

收起
查看更多

氯烯雌醚上游原料

共找到15个上游原料
查看更多上游原料 >

氯烯雌醚下游产品

共找到5个下游产品
查看更多下游产品 >
您可能感兴趣的化合物
快捷导航
其他 化学试剂 卤化物
上游原料
氯 苯甲醚 甲氧滴滴涕 1,2,2-tris(4-methoxyphenyl)ethanone Dimethyl 1-chloro-1-(4-methoxyphenyl)methanephosphonate (4-甲氧基苄基)膦酸二甲酯 对甲氧基苯乙酸乙酯 2-(4-甲氧基苯基)-2-氧代乙醛 四氯化碳 4,4'-二甲氧基二苯甲酮 4-甲氧基氯苄 4,4',4''-(1-乙烯基-2-亚基)三苯甲醚 3-甲基-CBS-氧硼啶 1,1,2-三(4-甲氧苯基)乙醇 1-bromo-1,2,2-tris(p-methoxyphenyl)ethene
下游产品
9-chloro-3,6-dimethoxy-10-(p-methoxyphenyl)phenanthrene 1-Acetoxy-1,2,2-tris(4-methoxyphenyl)ethene 4,4'-二甲氧基二苯甲酮 4,4',4''-(1-乙烯基-2-亚基)三苯甲醚
上游原料厂家
甲氧滴滴涕厂家 对甲氧基苯乙酸乙酯厂家 4,4'-二甲氧基二苯甲酮厂家 苯甲醚厂家 3-甲基-CBS-氧硼啶厂家 4-甲氧基氯苄厂家 四氯化碳厂家 2-(4-甲氧基苯基)-2-氧代乙醛厂家 (4-甲氧基苄基)膦酸二甲酯厂家
下游原料厂家
4,4'-二甲氧基二苯甲酮厂家
上游原料批发
甲氧滴滴涕 对甲氧基苯乙酸乙酯 4,4'-二甲氧基二苯甲酮 苯甲醚 3-甲基-CBS-氧硼啶 4-甲氧基氯苄 四氯化碳 2-(4-甲氧基苯基)-2-氧代乙醛 (4-甲氧基苄基)膦酸二甲酯
下游原料批发
4,4'-二甲氧基二苯甲酮
569-57-3 氯烯雌醚
氯烯雌醚
CAS号：569-57-3 分子式：C23H21ClO3 分子量：380.86400
查看供应商 立即选购

化工圈APP

二维码

微信公众号

二维码
关于我们 商务合作 厂家库 产品库 摩贝百科 摩贝行情 移动站 联系我们 法律声明 营业执照 帮助中心 投资者关系
Copyright © 2013-2024 MOLBASE All Rights Reserved 上海摩企数据技术有限公司
沪公网安备 31010402005161号 | 沪ICP备2024066981号-2 | 增值电信业务经营许可证： 沪B2-20140080

购物车

不要让您的购物车空着哦，买试剂、买原料
如果您已添加过宝贝，那就赶紧登录查看吧

获取报价

已选 清空
等0家供应商
  • 商品名称
  • CAS号
  • 采购数量*
  • 单位*
  • 纯度
  • 联系人
  • 联系人手机*
  • 需求时效*
  • 收货地址*
  •  
  • 公司/单位*
  • 备注
  • 手机号码必须为11位数字！
    立即提交

投诉建议

  • 咨询类别
  • 问题描述
  • 联系人电话
  • 联系人
  • 手机号码必须为11位数字！