| Product name | acetophenone |
|---|
| Product number | - |
|---|---|
| Other names | Ethanone,1-phenyl |
| Identified uses | For industry use only. Acetophenone is used in perfumery as a fragrance ingredient in soaps, detergents, creams, lotions, and perfumes; as a flavoring agent in foods, nonalcoholic beverages, and tobacco; as a specialty solvent for plastics and resins; as a catalyst for the polymerization of olefins; and in organic syntheses as a photosensitizer. |
|---|---|
| Uses advised against | no data available |
| Company | MOLBASE (Shanghai) Biotechnology Co., Ltd. |
|---|---|
| Address | Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, Xuhui District, Shanghai, China |
| Telephone | +86(21)64956998 |
| Fax | +86(21)54365166 |
| Emergency phone number | +86-400-6021-666 |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
Acute toxicity - Oral, Category 4
Eye irritation, Category 2
2.2 GHS label elements, including precautionary statements| Pictogram(s) |  |
|---|---|
| Signal word | Warning |
| Hazard statement(s) | H302 Harmful if swallowed H319 Causes serious eye irritation |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. |
| Response | P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell. P330 Rinse mouth. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. |
| Storage | none |
| Disposal | P501 Dispose of contents/container to ... |
none
3.Composition/information on ingredients 3.1 Substances| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| acetophenone | acetophenone | 98-86-2 | none | 100% |
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaledFresh air, rest. Refer for medical attention.
In case of skin contactRemove contaminated clothes. Rinse skin with plenty of water or shower.
In case of eye contactFirst rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
If swallowedRinse mouth. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayedNo toxicity expected from inhalation or ingestion except slight narcotic effect. Liquid can cause eye and skin irritation on contact. (USCG, 1999)
4.3 Indication of immediate medical attention and special treatment needed, if necessaryCall for medical aid. ... Remove contaminated clothing and shoes. Flush affected areas with plenty of water. IF IN EYES, hold eyelids open, and flush with plenty of water. IF SWALLOWED and victim is CONSCIOUS, have victim drink water, or milk.
5.Fire-fighting measures 5.1 Extinguishing media Suitable extinguishing mediaExtinguish with water, foam, dry chemical, carbon dioxide.
5.2 Specific hazards arising from the chemicalExcerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. Substance may be transported hot. For hybrid vehicles, ERG Guide 147 (lithium ion batteries) or ERG Guide 138 (sodium batteries) should also be consulted. If molten aluminum is involved, refer to ERG Guide 169. (ERG, 2016)
5.3 Special protective actions for fire-fightersWear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures 6.1 Personal precautions, protective equipment and emergency proceduresUse personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautionsPersonal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning upAbsorb on paper. Evaporate on a glass or iron dish in hood. Burn the paper.
7.Handling and storage 7.1 Precautions for safe handlingAvoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilitiesSeparated from strong oxidants. Ventilation along the floor.In general materials... toxic as stored or which can decompose into toxic components... should be stored in cool... ventilated place, out of... sun, away from... fire hazard... be periodically inspected and monitored. Incompatible materials should be isolated.
8.Exposure controls/personal protection 8.1 Control parameters Occupational Exposure limit valuesno data available
Biological limit valuesno data available
8.2 Appropriate engineering controlsHandle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE) Eye/face protectionSafety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protectionWear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protectionWear dust mask when handling large quantities.
Thermal hazardsno data available
9.Physical and chemical properties| Physical state | clear to light yellow liquid |
|---|---|
| Colour | Liquid. Forms laminer crystals at low temperature. |
| Odour | SWEET, PUNGENT ODOR OF ACACIA |
| Melting point/ freezing point | 19.6ºC |
| Boiling point or initial boiling point and boiling range | 202ºC |
| Flammability | Combustible. |
| Lower and upper explosion limit / flammability limit | no data available |
| Flash point | 77ºC |
| Auto-ignition temperature | 570°C (USCG, 1999) |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | 2.28 cP @ 11.9°C; 1.59 cP @ 23.5°C; 1.617 cP @ 25°C; 1.246 cP @ 50°C; 0.734 cP @ 80°C |
| Solubility | Slightly sol in concn sulfuric acid; freely sol in alc, chloroform, ether, fatty oils, glycerol. |
| Partition coefficient n-octanol/water (log value) | log Kow= 1.58 |
| Vapour pressure | 0.397 mm Hg @ 25°C |
| Density and/or relative density | 1.0266 |
| Relative vapour density | 4.1 (Air=1) |
| Particle characteristics | no data available |
no data available
10.2 Chemical stabilityStable under normal laboratory storage conditions.
10.3 Possibility of hazardous reactions... /It/ does not form flammable mixtures with air at room temperature.ACETOPHENONE reacts with many acids and bases liberating heat and flammable gases (e.g., H2). Reacts with many oxidizing agents. Reacts with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. The amount of heat in these reactions may be sufficient to start a fire in the unreacted portion. Incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides.
10.4 Conditions to avoidno data available
10.5 Incompatible materialsno data available
10.6 Hazardous decomposition productsWhen heated to decomposition it emits acrid smoke and fumes.
11.Toxicological information Acute toxicity- Oral: LD50 Rat (male Wistar) oral 3.0 g/kg (14 day range finding test)
- Inhalation: no data available
- Dermal: no data available
no data available
Serious eye damage/irritationno data available
Respiratory or skin sensitizationno data available
Germ cell mutagenicityno data available
CarcinogenicityCancer Classification: Group D Not Classifiable as to Human Carcinogenicity
Reproductive toxicityNo information is available on the reproductive or developmental effects of acetophenone in humans. In one study of pregnant rats exposed dermally, no effects on reproduction or development were noted.
STOT-single exposureno data available
STOT-repeated exposureno data available
Aspiration hazardno data available
12.Ecological information 12.1 Toxicity- Toxicity to fish: LC50 Pimephales promelas (fathead minnow) 162 mg/l/96 hr (confidence limit not reliable), flow-through bioassay with measured concentrations, 24.6°C, dissolved oxygen 7.1 mg/l, hardness 40.7 mg/l calcium carbonate, alkalinity 35.0 mg/l calcium carbonate, and pH 7.83
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Acetophenone, present at 100 mg/l, achieved 61-68% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/l and the Japanese MITI test(1). Other screening studies give similar results and acetophenone is confirmed to be biodegradable(2-4). Acetophenone achieved 20-32% of its theoretical BOD using a sewage inoculum over a 5 day incubation period(2,3). Acetophenone reached 59% of its theoretical BOD using acclimated mixed microbial cultures and a 5 day incubation period(4). The biodegradation half-lives of acetophenone in groundwater, river water and lake water were 32, 8 and 4.5 days, respectively(5,6).
12.3 Bioaccumulative potentialAn estimated BCF of 0.5 was calculated for acetophenone(SRC), using a log Kow of 1.58(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soilThe Koc of acetophenone was measured as 10, using an agricultural soil obtained from Northeastern China(1). According to a classification scheme(2), this Koc value suggests that acetophenone is expected to have very high mobility in soil(SRC).
12.5 Other adverse effectsno data available
13.Disposal considerations 13.1 Disposal methods ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packagingContainers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information 14.1 UN Number| ADR/RID: no data available | IMDG: no data available | IATA: no data available |
| ADR/RID: no data available |
| IMDG: no data available |
| IATA: no data available |
| ADR/RID: no data available | IMDG: no data available | IATA: no data available |
| ADR/RID: no data available | IMDG: no data available | IATA: no data available |
| ADR/RID: no | IMDG: no | IATA: no |
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Codeno data available
15.Regulatory information 15.1 Safety, health and environmental regulations specific for the product in question| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| acetophenone | acetophenone | 98-86-2 | none |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Not Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Creation Date | Aug 20, 2017 |
|---|---|
| Revision Date | Aug 20, 2017 |
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
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