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621-44-3 3-硝基-L-酪氨酸

3-硝基-L-酪氨酸

英文名称:3-nitro-L-tyrosine
CAS:

621-44-3

分子式:C9H10N2O5
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3-硝基-L-酪氨酸简介

Nitrotyrosine is a product of tyrosine nitration mediated by reactive nitrogen species such as peroxynitrite anion and nitrogen dioxide. Nitrotyrosine is identified as an indicator or marker of cell damage, inflammation as well as NO (nitric oxide) production. Nitrotyrosine is formed in the presence of the active metabolite NO. Generally in many disease states, oxidative stress increases the production of superoxide (O2−) and NO forming peroxynitrite (ONOO−) a destructive free radical oxidant. The production of ONOO− is capable of oxidizing several lipoproteins and of nitrating tyrosine residues in many proteins. It is difficult to determine the production of ONOO− so, usually nitrotyrosine in proteins are the detectable marker for indirectly detecting ONOO−. It is detected in large number of pathological conditions and is considered a marker of NO-dependent, reactive nitrogen species-induced nitrative stress. Nitrotyrosine is detected in biological fluids such as plasma, lung aspirants-BALF (Broncho alveolar lining fluid) and urine. Increased level of nitrotyrosine is detected in rheumatoid arthritis septic shock and coeliac disease. In all these studies nitrotyrosine was undetected in healthy subjects. Nitrotyrosine is also found in numerous other disease-affected tissues, such as the cornea in keratoconus. Peroxynitrite and/or nitrative stress may participate in the pathogenesis of diabetes
Research shows that nitrotyrosine levels can be reduced by N-acetyl cysteine, which is a precursor to glutathione, one of the body's primary endogenous antioxidants. Nitrotyrosine levels have been linked to cerebral ischemia and edema, for which NAC has also been proven as a potential treatment.
Free nitrotyrosine undergoes metabolism to form 3-nitro-4-hydroxyphenylacetic acid (NHPA) which is excreted in the urine.

3-硝基-L-酪氨酸基本信息

中文名称 3-硝基-L-酪氨酸 英文名称 3-nitro-L-tyrosine
中文别名

3-硝基-酪氨酸; 间硝基酪氨酸;

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英文别名

H-3-NITRO-TYR-OH; L-3-NO2-Tyr; NITROTYROSINE; H-M-NITRO-TYR-OH; M-NITRO-L-TYROSINE; L-Tyrosine, 3-nitro-; 3-NITRO-TYROSINE; 3-Nitro-L-tyrosine; L-4-hydroxy-3-nitro-phenylalanine; H-3-NITRO-L-TYROSINE;

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CAS号 621-44-3 分子式 C9H10N2O5
分子量 226.18600 精确质量 226.05900
PSA 129.37000 LOGP 1.47830

3-硝基-L-酪氨酸编号系统

MDL号 MFCD00007123

3-硝基-L-酪氨酸物化性质

外观与性状:
黄色至绿色粉末
密度:
1.531 g/cm3
沸点:
431.6ºC at 760 mmHg
熔点:
233-235ºC (dec.)
闪点:
214.8ºC
稳定性:
Stable under normal temperatures and pressures.
储存条件:
-15ºC

安全信息

安全说明:
S26-S37/39
危险类别码:
R36/37/38
海关编码:
2922509090
危险品标志:
Xi
SDS 1.0 中文 展开
SDS 1.0 英文 展开
MSDS 中文 展开
1H NMR : Predict展开

核磁图谱 1H NMR : Predict

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国家名称 海关编码 海关数据更新时间 操作
中国 2922509090 2019-03 申报要素
美国 2922504000 2019-03 概述
印度 29225090 2019-03 概述
欧盟 29225000 2019-03 概述
英国 2922500090 2019-03 概述
日本 292250000 2019-03 概述
韩国 2922509000 2019-03 概述
加拿大 2922500090 2019-03 概述
3-硝基-L-酪氨酸
CAS号:621-44-3 分子式:C9H10N2O5 分子量:226.18600

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