1445-07-4 假尿苷

假尿苷

英文名称:pseudouridine
CAS:

1445-07-4

分子式:C9H12N2O6
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  • 基本信息
  • 物化性质
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  • 上游原料
  • 下游产品

假尿苷简介

Pseudouridine (abbreviated by the Greek letter psi- Ψ) is an isomer of the nucleoside uridine in which the uracil is attached via a carbon-carbon instead of a nitrogen-carbon glycosidic bond. It is the most prevalent of the over one hundred different modified nucleosides found in RNA. Ψ is found in all species and in many classes of RNA. Ψ is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation.
Pseudouridine is biosynthesized from uridine via the action of Ψ synthases.
It is commonly found in tRNA, associated with thymidine and cytosine in the TΨC arm and is one of the invariant regions of tRNA.The function of it is not very clear, but it is expected to play a role in association with aminoacyl transferases during their interaction with tRNA, and hence in the initiation of translation. Recent studies suggest it may offer protection from radiation.
A tRNAAla from S.cerevisiae. Pseudouridine = Ψ

假尿苷基本信息

中文名称 假尿苷 英文名称 pseudouridine
中文别名

5-Β-D-核呋喃基尿嘧啶;

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英文别名

β-Pseudouridine;

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CAS号 1445-07-4 分子式 C9H12N2O6
分子量 244.20100 精确质量 244.07000
PSA 135.64000 LOGP -2.78280

假尿苷物化性质

密度:
1.641g/cm3
沸点:
598.4ºC at 760mmHg
闪点:
315.7ºC
折射率:
1.623
蒸汽压:
3.63E-15mmHg at 25°C
SDS 1.0 中文 展开
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1H NMR : Predict展开

核磁图谱 1H NMR : Predict

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上游原料
5-(2,3,5-tri-O-benzyl-D-altro-pentahydroxypentyl)-2,4-di-t-butoxypyrimidine D-(+)-核糖酸-1,4-内酯 5-(2,3,5-tri-O-methyl-β-D-ribofuranosyl)uracil 2,3-O-isopropylidene-5-O-(1-methoxy-1-methyl-ethyl)-D-ribono-1,4-lactone 伪异胞苷 (2R,3S,4R,5S)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-5-(2,4-dimethoxypyrimidin-5-yl)tetrahydrofuran-3,4-diol 2,4:3,5-二-O-亚苄基-醛基-D-核糖水合物 (2R,3R,4S,5S)-2-(acetoxymethyl)-5-(2,4-bis(methylthio)pyrimidin-5-yl)tetrahydrofuran-3,4-diyl diacetate 2,4-di-tert-butoxy-5-((3aS,4S,6R,6aR)-6-(((2-methoxypropan-2-yl)oxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)pyrimidine 5'-O-(tert-butyldiphenylsilyl)pseudouridine (R)-1-((4R,5S)-5-((R)-(2,4-di-tert-butoxypyrimidin-5-yl)(hydroxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-((2-methoxypropan-2-yl)oxy)ethanol 5'-O-(tert-butyldiphenylsilyl)-2',3'-O-(isopropylidene)pseudouridine (+/-)-1-hydroxy-1.1.3-triphenyl-butane (1Ξ)-O2,O4,O3,O5-(R,R)-dibenzylidene-1-(2,4-bis-benzyloxy-pyrimidin-5-yl)-D-ribitol 5-(2,3-O-isopropylidene-β-D-ribofuranosyl)uracil 5-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)uracil
下游产品
3'-Deoxy-ψ-uridine 3-甲基-5-beta-D-呋喃核糖基-2,4(1H,3H)-嘧啶二酮 脱氧假尿苷 (1R)-1,4-脱水-2-脱氧-1-(1,3-二甲基-2,4-二氧代-1,2,3,4-四氢-5-嘧啶基)-D-赤式-戊糖醇 PSEUDOTHYMIDINE 1-methyl-2'-deoxy-5'-O-tritylpseudouridine
上游原料厂家
2,4:3,5-二-O-亚苄基-醛基-D-核糖水合物厂家 伪异胞苷厂家 D-(+)-核糖酸-1,4-内酯厂家 5'-O-(tert-butyldiphenylsilyl)pseudouridine厂家 2,3-O-isopropylidene-5-O-(1-methoxy-1-methyl-ethyl)-D-ribono-1,4-lactone厂家
下游原料厂家
(1R)-1,4-脱水-2-脱氧-1-(1,3-二甲基-2,4-二氧代-1,2,3,4-四氢-5-嘧啶基)-D-赤式-戊糖醇厂家 PSEUDOTHYMIDINE厂家 脱氧假尿苷厂家
上游原料批发
2,4:3,5-二-O-亚苄基-醛基-D-核糖水合物 伪异胞苷 D-(+)-核糖酸-1,4-内酯 5'-O-(tert-butyldiphenylsilyl)pseudouridine 2,3-O-isopropylidene-5-O-(1-methoxy-1-methyl-ethyl)-D-ribono-1,4-lactone
下游原料批发
(1R)-1,4-脱水-2-脱氧-1-(1,3-二甲基-2,4-二氧代-1,2,3,4-四氢-5-嘧啶基)-D-赤式-戊糖醇 PSEUDOTHYMIDINE 脱氧假尿苷
假尿苷
CAS号:1445-07-4 分子式:C9H12N2O6 分子量:244.20100

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