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硫氰酸胍

英文名称: Guanidine thiocyanate

CAS号:593-84-0 分子式:C2H6N4S 分子量:118.16100

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简介

Guanidinium thiocyanate (GITC) is a chemical compound used as a general protein denaturant, being a chaotropic agent, although it is most commonly used in the extraction of DNA and RNA.
Note: this compound may also be recognized as guanidine thiocyanate. This is because guanidinium is the conjugate acid of guanidine and is called the guanidinium cation, [CH6N3]+.
Guanidinium thiocyanate can be used to deactivate a virus, such as the influenza virus that caused the 1918 "Spanish flu", so that it can be studied safely. This application is presumably based on its denaturation activity.
Guanidinium thiocyanate is also used to lyse cells and virus particles in RNA and DNA extractions, where its function, in addition to its lysing action, is to prevent activity of RNase enzymes and DNase enzymes by denaturing them. These enzymes would otherwise damage the extract.
A commonly used method is guanidinium thiocyanate-phenol-chloroform extraction. It is not strictly necessary to use phenol or chloroform if extracting RNA for Northern blotting or DNA for Southern blot analysis because the gel electrophoresis followed by transfer to a membrane will separate the RNA/DNA from the proteins. Additionally, since these methods use probes to bind to their conjugates, peptides that get through the process don't generally matter unless a peptide is an RNase or DNase, and then only if the enzyme manages to renature, which should not occur if proper protocols are followed. A possible exception might be when working with temperature extremophiles because some enzymes of these organisms can remain stable under extraordinary circumstances.

基本信息

中文名称 硫氰酸胍 英文名称 Guanidine thiocyanate
中文别名

硫氰酸胍[用于生化研究]; 胍硫氰酸盐; 硫氰酸胍,; 异硫氰酸胍; 硫氰酸亚脲;

查看更多中文别名
英文别名

GUANIDINE RHODANIDE; Guandine thiocyanate; guanidine monothiocyanate; Guanidinethiocyanate; GdmSCN; Thiocyanic acid, compd. with guanidine (1:1); GUANIDINIUM THIOCYANATE; Guanidine thiocyanat; GUANIDINIUM RHODANIDE; Guanidiniumthiocyanat; GTC; thiocyanic acid,guanidine salt; usafek-705;

查看更多英文别名
CAS号 593-84-0 分子式 C2H6N4S
分子量 118.16100 精确质量 118.03100
PSA 138.48000 LOGP 0.73618

编号系统

EINECS号 209-812-1

物化性质

外观与性状:
白色粉末
密度:
1.103 g/mL at 20 °C
沸点:
132.9ºC at 760 mmHg
熔点:
120-122 °C(lit.)
闪点:
34.2ºC
折射率:
n20/D 1.482
稳定性:
Stability Stable, but light sensitive. Incompatible with acids (contact releases very toxic gas), strong oxidising agents.
储存条件:
Store at RT.

安全信息

RTECS号:
XL1225000
安全说明:
S36/37-S61-S13
危险类别码:
R20/21/22; R32; R52/53
WGK Germany:
2
危险品运输编码:
1759
海关编码:
2925290090
危险类别:
8
包装等级:
III
危险品标志:
Xn
危险性防范说明:
P260; P280; P301 + P312 + P330; P303 + P361 + P353; P304 + P340 + P310; P305 + P351 + P338
补充危害声明:
与酸接触会释放有毒气体。
危险标志:
GHS05, GHS07
危险性描述:
H302 + H312 + H332; H314; H412
信号词:
Danger

生产方法及用途

用途

2、用途强变性剂,主要用于生物医药。用于变性裂解细胞;提取RNA和DNA。无RNA酶和DNA酶活性。

SDS 1.0 中文 展开
SDS 1.0 英文 展开
MSDS 中文 展开
1H NMR : Predict展开

核磁图谱 1H NMR : Predict

收起
国家名称 海关编码 海关数据更新时间 操作
中国 2925290090 2019-03 申报要素

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上游原料厂家
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硝基胍厂家 2-氨基-4,6(1H,5H)-嘧啶二酮厂家 6-氨基-4H-[1,3]二噻英并[5,4-d]嘧啶-8(5H)-酮厂家 2-氨基-4-羟基-6-甲基嘧啶厂家 1-苯基-3-脒基硫脲厂家 2-氨基-4,6-二羟基-5-甲基嘧啶厂家
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硫氰酸胍

CAS号:593-84-0 分子式:C2H6N4S 分子量:118.16100

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