首页 > 化工百科 > 其他 > 化学试剂 > 芳香化合物 > 细胞松弛素B

细胞松弛素B

英文名称: cytochalasin B

CAS号:14930-96-2 分子式:C29H37NO5 分子量:479.60800

摩贝参考价:
暂无任何报价 我要报价

关于参考价
摩贝参考价是根据供应商的报价结合成交价,通过一定
算法规则计算出的报价,仅供数据参考,该价格每个月
会进行一轮更新。

简介

Cytochalasin B, the name of which comes from the Greek cytos (cell) and chalasis (relaxation), is a cell-permeable mycotoxin. It was found that substoichimetric concentrations of cytochalasin B (CB) strongly inhibit network formation by actin filaments. Due to this, it is often used in cytological research. It inhibits cytoplasmic division by blocking the formation of contractile microfilaments. It inhibits cell movement and induces nuclear extrusion. Cytochalasin B shortens actin filaments by blocking monomer addition at the fast-growing end of polymers. Cytochalasin B inhibits glucose transport and platelet aggregation. It blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells. It is also used in cloning through nuclear transfer. Here enucleated recipient cells are treated with cytochalasin B. Cytochalasin B makes the cytoplasm of the oocytes more fluid and makes it possible to aspirate the nuclear genome of the oocyte within a small vesicle of plasma membrane into a micro-needle. Thereby, the oocyte genome is removed from the oocyte, while preventing rupture of the plasma membrane.
This alkaloid is isolated from a fungus, Helminthosporium dematioideum.

基本信息

中文名称 细胞松弛素B 英文名称 cytochalasin B
中文别名

细胞松弛素 B;

查看更多中文别名
英文别名

Cytochalasin B;

查看更多英文别名
CAS号 14930-96-2 分子式 C29H37NO5
分子量 479.60800 精确质量 479.26700
PSA 95.86000 LOGP 3.82090

物化性质

外观与性状:
粉末
密度:
1.2 g/cm3
沸点:
740.6ºC at 760 mmHg
熔点:
218-223ºC
闪点:
401.7ºC
折射率:
1.596
储存条件:
-20ºC
蒸汽压:
4.98E-23mmHg at 25°C

安全信息

安全说明:
28-36/37-45
危险类别码:
R26/27/28; R63
危险品运输编码:
UN 1544 6
危险类别:
6.1(a)
危险品标志:
T+
SDS 1.0 中文 展开
SDS 1.0 英文 展开
13C NMR : Predict展开

核磁图谱 13C NMR : Predict

收起
毒性类型/接触途径 测试类型 测试物种 剂量/时间 毒性作用
急性毒性

(腹腔)

LD50 - 致命剂量,杀死50% 啮齿动物 - 大鼠 11 mg/kg 1、行为改变-共济失调
2、行为改变-昏迷
3、肺部,胸部或呼吸毒性-黄萎病
急性毒性

(腹腔)

LD50 - 致命剂量,杀死50% 啮齿动物 - 小鼠 30 mg/kg 1、除致死量外无其他报道
生殖毒性

(口服)

TDLo - 公布的最低毒性剂量 啮齿动物 - 小鼠 1500 ug/kg,受孕后8天 1、生殖毒性-具体的发育异常-中枢神经系统
2、生殖毒性-具体的发育异常-肌肉骨骼系统

店铺商品推荐

您可能感兴趣的化合物

快捷导航
其他 化学试剂 芳香化合物
上游原料
(3E,5R,9S,11E,12aS,15S,15aS,16S,18aR)-16-benzyl-5-((tert-butyldimethylsilyl)oxy)-9,14,15-trimethyl-6,7,8,9,10,12a,15,15a,16,17-decahydro-2H-[1]oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione (3E,5R,9S,11E,12aS,15S,15aS,16S,18aR)-17-acetyl-16-benzyl-5-((tert-butyldimethylsilyl)oxy)-9,14,15-trimethyl-6,7,8,9,10,12a,15,15a,16,17-decahydro-2H-[1]oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione (1E,4S,8R,9E,12aS,15S,15aS,16S,16aR,17aS,17bS)-14-acetyl-15-benzyl-8-((tert-butyldimethylsilyl)oxy)-4,16,16a-trimethyl-3,5,6,7,8,14,15,15a,16,16a,17a,17b-dodecahydro-11H-[1]oxacyclotetradecino[2,3-d]oxireno[2,3-f]isoindole-11,13(4H)-dione (3S,3aS,10S,14R,18aR,E)-2-acetyl-3-benzyl-14-((tert-butyldimethylsilyl)oxy)-4,5,10-trimethyl-3,3a,4,6a,9,10,11,12,13,14,15,16-dodecahydro-1H-[1]oxacyclotetradecino[2,3-d]isoindole-1,17(2H)-dione (3S,3aS,4R,6aR,10S,14R,18aR,E)-3-benzyl-14-((tert-butyldimethylsilyl)oxy)-4,5,10-trimethyl-3,3a,4,6a,9,10,11,12,13,14,15,16-dodecahydro-1H-[1]oxacyclotetradecino[2,3-d]isoindole-1,17(2H)-dione

细胞松弛素B

CAS号:14930-96-2 分子式:C29H37NO5 分子量:479.60800

化工圈APP

二维码

微信公众号

二维码

购物车

不要让您的购物车空着哦,买试剂买原料
如果您已添加过宝贝,那就赶紧登录查看吧

摩贝客服

试剂业务咨询

400-6021-666 转 2
立即咨询

综合业务咨询

400-6021-666
立即咨询

粉末涂料咨询

400-6021-666
立即咨询

投诉建议

  • 咨询类别
  • 问题描述
  • 联系人电话
  • 联系人