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2-甲氧基雌二醇

英文名称: 2-methoxy-17β-estradiol

CAS号:362-07-2 分子式:C19H26O3 分子量:302.40800

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简介

2-Methoxyestradiol (2-ME2) is a natural metabolite of estradiol. As an experimental drug candidate, it is being developed under the tradename of Panzem. It prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis), hence it is an angiogenesis inhibitor.
It also acts as a vasodilator.; 2-ME2 is derived from estradiol, although it binds poorly (2000-fold lower activational potency) to known estrogen receptors. However, 2-ME2 retains activity as a high-affinity agonist of the GPER (GPR30).
It induces apoptosis in some cancer cell lines.
It has undergone Phase 1 clinical trials against breast cancer.; A phase II trial of 18 advanced ovarian cancer patients reported encouraging results in Oct 2007.
Preclinical models also suggest that 2-ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis. Several studies have been conducted showing 2-ME2 is a microtubule-inhibitor and effective against prostate cancer in rodents.; As of 2015, all clinical development of 2-ME2 has been suspended or discontinued.

基本信息

中文名称 2-甲氧基雌二醇 英文名称 2-methoxy-17β-estradiol
中文别名

盐酸拓扑替康; 3,17Β-二羟基-2-甲氧基-1,3,5(10)-雌甾三烯; 1,3,5(10)-雌甾三烯-2,3,17-三醇二甲醚; 2-甲氧基-β-雌二醇; 2-甲氧雌二醇;

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英文别名

2-Methoxyestradiol; 2-Methoxy-β-estradiol; 2-methoxy-17beta-estradiol; 2-Methoxy 17β-Estradiol;

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CAS号 362-07-2 分子式 C19H26O3
分子量 302.40800 精确质量 302.18800
PSA 49.69000 LOGP 3.61780

编号系统

UNII 6I2QW73SR5

物化性质

外观与性状:
灰白色固体
密度:
1.178g/cm3
沸点:
464.4ºC at 760mmHg
熔点:
188-190°C
闪点:
234.7ºC
折射率:
1.586
储存条件:
-20ºC

安全信息

RTECS号:
KG7537500
安全说明:
S22; S26; S36/37/39; S45; S53; S36
危险类别码:
R23/24/25
WGK Germany:
3
危险品运输编码:
UN 3077 9/PG 3
危险品标志:
T
信号词:
Danger
危险性描述:
H301 + H311 + H331; H315; H319; H335; H350; H360; H372; H410
危险标志:
GHS06, GHS08, GHS09
危险性防范说明:
P201; P261; P273; P280; P301 + P310; P305 + P351 + P338
SDS 1.0 中文 展开
SDS 1.0 英文 展开
MSDS 中文 展开
1H NMR : Predict展开

核磁图谱 1H NMR : Predict

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其他 化学试剂 芳香化合物
上游原料
2-formyl-3-O-methoxymethyl-17,17-ethylenedioxyestrone 2-甲氧基雌素酮 (17beta)-3,17-二(甲氧基甲氧基)雌甾-1(10),2,4-三烯-2-甲醛 2-methoxy-3-O-methoxymethyl-17,17-ethylenedioxyestrone (8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-2-carbaldehyde 2-acetyl-3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl acetate (8R,9S,13S,14S,17S)-2-methoxy-3,17-bis(methoxymethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene 2-(17β-acetoxy-2-methoxy-estra-1,3,5(10)-trien-3-yloxy)-5-nitro-benzophenone (17beta)-3,17-二(甲氧基甲氧基)雌甾-1(10),2,4-三烯-2-醇 2-hydroxy-3-O-methoxymethyl-17,17-ethylenedioxyestrone 2-溴雌二醇 (17beta)-3,17-二(甲氧基甲氧基)雌甾-1,3,5(10)-三烯 雌酚酮 3-Benzyloxy-2-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol 甲醇钠 3-benzyloxyestra-1,3,5(10)-triene-2,17β-diol Acetic acid 2-acetoxy-3-benzyloxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester 2-acetyl-3-benzyloxyestra-1,3,5(10)-triene-17β-ol 17-acetate 3,17β-bis(benzyloxy)estra-1,3,5(10)-triene-2-carbaldehyde 2-methoxyestradiol bis-THP ether 2-hydroxy-3,17β-bis(benzyloxy)estra-1,3,5(10)-triene estradiol-3,17α-diacetate 3,17β-bis(benzyloxy)-2-methoxyestra-1,3,5(10)-triene 2-碘雌二醇 2-(17β-hydroxy-estra-1,3,5(10)-trien-3-yloxy)-5-nitro-benzophenone 雌二醇 2,4-二溴雌二醇 雌酮17-乙烯缩酮
下游产品
2-甲氧基雌素酮 雌甾-1,3,5(10)-三烯2,3,17-三醇
上游原料厂家
2-碘雌二醇厂家 2-甲氧基雌素酮厂家 (17beta)-3,17-二(甲氧基甲氧基)雌甾-1,3,5(10)-三烯厂家 2-溴雌二醇厂家 (17beta)-3,17-二(甲氧基甲氧基)雌甾-1(10),2,4-三烯-2-醇厂家 雌二醇厂家 雌酚酮厂家 甲醇钠厂家 (17beta)-3,17-二(甲氧基甲氧基)雌甾-1(10),2,4-三烯-2-甲醛厂家
下游原料厂家
2-甲氧基雌素酮厂家 雌甾-1,3,5(10)-三烯2,3,17-三醇厂家
上游原料批发
2-碘雌二醇 2-甲氧基雌素酮 (17beta)-3,17-二(甲氧基甲氧基)雌甾-1,3,5(10)-三烯 2-溴雌二醇 (17beta)-3,17-二(甲氧基甲氧基)雌甾-1(10),2,4-三烯-2-醇 雌二醇 雌酚酮 甲醇钠 (17beta)-3,17-二(甲氧基甲氧基)雌甾-1(10),2,4-三烯-2-甲醛
下游原料批发
2-甲氧基雌素酮 雌甾-1,3,5(10)-三烯2,3,17-三醇

2-甲氧基雌二醇

CAS号:362-07-2 分子式:C19H26O3 分子量:302.40800

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