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17Alpha-羟基黄体酮

英文名称: 17α-hydroxyprogesterone

CAS号:68-96-2 分子式:C21H30O3 分子量:330.46100

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简介

17α-Hydroxyprogesterone (17α-OHP), or hydroxyprogesterone (OHP) (INN, BAN), also known as 17α-hydroxypregn-4-ene-3,20-dione, is an endogenous progestogen steroid hormone related to progesterone. It is also a chemical intermediate in the biosynthesis of many other endogenous steroids, including androgens, estrogens, glucocorticoids, and mineralocorticoids, as well as neurosteroids.
Under the brand name Gestageno, 17α-OHP has been marketed for clinical use in Argentina. However, esters of 17α-OHP, including hydroxyprogesterone caproate, as well as hydroxyprogesterone acetate and hydroxyprogesterone heptanoate to a much lesser extent, have been used far more widely in comparison, and when "hydroxyprogesterone" is referenced from the standpoint of medical use, what is usually being referred to is actually, in general, hydroxyprogesterone caproate.
17α-OHP is also the parent compound of a class of progestins referred to as the 17α-hydroxyprogesterone derivatives. Among others, this class of drugs includes chlormadinone acetate, cyproterone acetate, hydroxyprogesterone caproate, medroxyprogesterone acetate, and megestrol acetate.

基本信息

中文名称 17Alpha-羟基黄体酮 英文名称 17α-hydroxyprogesterone
中文别名

17α-羟基孕酮; 17Α-羟基孕甾酮; 17α-羟基孕甾-4-烯-3,20-二酮; 17Alpha-羟基孕酮; 17-alpah-羟基黄体酮; 17-ALPHA-羟基孕酮; 羟孕酮; 17a-羟基黄体酮; 17a-羟基-黄体酮; 17Alpha-羟孕酮; 17α-羟孕酮; 羟黄酮;

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英文别名

Pregn-4-ene-3,20-dione, 17-hydroxy-; 17alpha-Hydroxyprogesterone; 17α-Hydroxyprogesterone;

查看更多英文别名
CAS号 68-96-2 分子式 C21H30O3
分子量 330.46100 精确质量 330.21900
PSA 54.37000 LOGP 3.69430

物化性质

外观与性状:
白色固体
密度:
1.15 g/cm3
沸点:
482.9ºC at 760 mmHg
熔点:
276°C
闪点:
259.9ºC
折射率:
90 ° (C=1, CHCl3)
储存条件:
-20ºC Freezer

安全信息

RTECS号:
TU5060000
安全说明:
S53-S22-S36/37/39-S45
WGK Germany:
3
危险类别码:
R61
危险品标志:
T

生产方法及用途

用途

制药工业上主要用作安宫黄体酮、甲地孕酮等原药的中间体。

SDS 1.0 中文 展开
SDS 1.0 英文 展开
MSDS 中文 展开
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核磁图谱 1H NMR : Predict

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生物及医药化学品 医药中间体
上游原料
重氮甲烷 脱氧可的松 表雄酮 16,17-环氧黄体酮 cyclic-3-(1,2-ethanediylmercapto)-17α-hydroxypregn-4-en-20-one 16,17-alpha环氧孕烯醇酮 17-hydroxy-2ξ-iodo-pregn-4-ene-3,20-dione 巯基乙酸 17α-hydroxypregn-4-en-20-yn-3-one (8R,10R,13S,Z)-10,13-dimethyl-17-(1-((tripropylsilyl)oxy)ethylidene)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one 17Alpha-羟基妊娠烯醇酮 5-Pregnen-3.β.,17.α.-diol-20-one-16.β.-bromo 5,6β-dichloro-3β,17-dihydroxy-5α-pregnan-20-one 4-孕烯-17Alpha,20Alpha-二醇- 3 -酮 20,20-ethanediyldioxy-pregn-5-ene-3β,17-diol 雄烯二酮 3,3-Ethylenedioxy-17α-hydroxy-androst-5-ene-17β-carbonitrile 氯化汞(II) 17α-hydroxy-21-chloro-4-pregnene-3,20-dione 黄体酮 16-去氢黄体酮 3beta,17-二羟基孕甾-5-烯-20-酮 3-甲酸酯 pregnadien-(4.17(20)t)-one-(3) 3,5-pregnadien-3,17-diol-20-one-3-methyl ether 17-羟基孕甾烷e-3,20-二酮 5α-Chloro-3β,17α-dihydroxypregnan-20-one (3beta)-3-(甲酰氧基)-20-氧代孕甾-5-烯-17-基乙酸酯 (8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate 3β-acetoxy-5-chloro-17,20ξ-epoxy-20ξ-formyloxy-5α-pregnane
下游产品
(8R,9S,10R,13S,14S,17R)-17-acetyl-4-chloro-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one 17β-hydroxyandrostan-3-one 17alpha-羟基孕甾-5-烯-3,20-二酮-3,20-二(乙烯缩酮) 17Alpha-羟基妊娠烯醇酮 睾酮 孕甾-4-烯-17Alpha,21-二醇-3,20-二酮-21-醋酸酯 脱氧可的松 雄烯二酮 11beta,17alpha-二羟基-4-孕烯-3,20-二酮 6beta,17alpha-二羟基黄体酮 17Alpha-羟基孕甾-4-烯-3,11,20-三酮 去氧皮质酮 氢化可的松 去氧皮质酮新戊酸酯 17Alpha-羟基孕烯醇酮-17-乙酸酯 17,21-二羟基孕甾-4-烯-3,20-二酮17,21-二(乙酸酯) 4-孕烷-17α,20β-二醇-3-酮 3-乙氧基-雄甾-3,5-二烯-17-酮
上游原料厂家
16,17-alpha环氧孕烯醇酮厂家 16-去氢黄体酮厂家 黄体酮厂家 4-孕烯-17Alpha,20Alpha-二醇- 3 -酮厂家 17-羟基孕甾烷e-3,20-二酮厂家 表雄酮厂家 17Alpha-羟基妊娠烯醇酮厂家 16,17-环氧黄体酮厂家 巯基乙酸厂家 脱氧可的松厂家
下游原料厂家
11beta,17alpha-二羟基-4-孕烯-3,20-二酮厂家 去氧皮质酮厂家 氢化可的松厂家 去氧皮质酮新戊酸酯厂家 3-乙氧基-雄甾-3,5-二烯-17-酮厂家 17Alpha-羟基孕烯醇酮-17-乙酸酯厂家 17Alpha-羟基妊娠烯醇酮厂家 孕甾-4-烯-17Alpha,21-二醇-3,20-二酮-21-醋酸酯厂家 脱氧可的松厂家 17Alpha-羟基孕甾-4-烯-3,11,20-三酮厂家
上游原料批发
16,17-alpha环氧孕烯醇酮 16-去氢黄体酮 黄体酮 4-孕烯-17Alpha,20Alpha-二醇- 3 -酮 17-羟基孕甾烷e-3,20-二酮 表雄酮 17Alpha-羟基妊娠烯醇酮 16,17-环氧黄体酮 巯基乙酸 脱氧可的松
下游原料批发
11beta,17alpha-二羟基-4-孕烯-3,20-二酮 去氧皮质酮 氢化可的松 去氧皮质酮新戊酸酯 3-乙氧基-雄甾-3,5-二烯-17-酮 17Alpha-羟基孕烯醇酮-17-乙酸酯 17Alpha-羟基妊娠烯醇酮 孕甾-4-烯-17Alpha,21-二醇-3,20-二酮-21-醋酸酯 脱氧可的松 17Alpha-羟基孕甾-4-烯-3,11,20-三酮

17Alpha-羟基黄体酮

CAS号:68-96-2 分子式:C21H30O3 分子量:330.46100

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