CAS号 5967-73-7 - (R)-二甲基(1-甲基-4-氧代-3,3-二苯基己基)氯化铵

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: (R)-二甲基(1-甲基-4-氧代-3,3-二苯基己基)氯化铵

英文名称：(6R)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone hydrochloride (1: 1)

CAS：
5967-73-7
分子式：C21H28ClNO

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(R)-二甲基(1-甲基-4-氧代-3,3-二苯...简介

Levomethadone (INN; L-Polamidon, L-Polamivet, Levadone, Levothyl), or levamethadone, is a synthetic opioid analgesic and antitussive which is marketed in Europe and is used for pain management and in opioid maintenance therapy. In addition to being used as a pharmaceutical drug itself, levomethadone, or R-(−)-methadone, is the active enantiomer of methadone, having approximately 50x the potency of the S-(+)-enantiomer as well as greater μ-opioid receptor selectivity. Accordingly, it is about twice as potent as methadone by weight and its effects are virtually identical in comparison. In addition to its activity at the opioid receptors, levomethadone has been found to act as a weak competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor complex and as a potent noncompetitive antagonist of the α3β4 nicotinic acetylcholine (nACh) receptor.
There is now an asymmetric synthesis available to prepare both levomethadone [R-(−)-methadone] and dextromethadone [S-(+)-methadone].
The separation of the stereoisomers is one of the easier in organic chemistry and is described in the original patent. It involves "treatment of racemic methadone base with d-(+)-tartaric acid in an acetone/water mixture [which] precipitates almost solely the dextro-methadone levo-tartrate, and the more potent levo-methadone can easily be retrieved from the mother liquor in a high state of optical purity"

(R)-二甲基(1-甲基-4-氧代-3,3-二苯...基本信息

中文名称	(R)-二甲基(1-甲基-4-氧代-3,3-二苯基己基)氯化铵	英文名称	(6R)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone hydrochloride (1: 1)
中文别名	查看更多中文别名	英文别名	(-)-Methylphenobarbital; 2,4,6(1H,3H,5H)-Pyrimidinetrione,5-ethyl-1-methyl-5-phenyl-,(R); R-(-)-methadone hydrochloride; (R)-(-)-mephobarbital; (-)-Mephobarbital; (-)-Methadone hydrochloride; (R)-6-dimethylamino-4,4-diphenyl-3-heptanone hydrochloride; (5S)-mephobarbital; (R)-Methylphenobarbital; UNII-5NC67NU76B component ALARQZQTBTVLJV-CYBMUJFWSA-N; (6R)-methadone hydrochloride; (R)-(6-dimethylamino-4,4-diphenylheptan-3-one) hydrochloride; 查看更多英文别名
CAS号	5967-73-7	分子式	C21H28ClNO
分子量	345.90600	精确质量	345.18600
PSA	20.31000	LOGP	5.09400