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(±)-3-氯-1,2-丙二醇

英文名称:3-chloropropane-1,2-diol

农药中间体 杀鼠剂 rodenticides
CAS : 96-24-2 精确质量 : 110.01300
分子式 : C3H7ClO2 logP : -0.42160
分子量 : 110.53900 PSA : 40.46000
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基本信息

纠错
中文名称:
(±)-3-氯-1,2-丙二醇
中文别名:

α-氯甘油;

α-氯丙二醇;

3-氯-1,2-丙二醇;

英文名称:
3-chloropropane-1,2-diol
英文别名:

3-chloro-1,2-propanediol;

3-Chloro-1,2-propanediol;

α-chlorohydrin;

(RS)-3-chloropropylene glycol;

CAS号:
96-24-2
分子式:
C3H7ClO2
分子量:
110.53900
精确质量:
110.01300
PSA:
40.46000

法规信息

中国
危险化学品

物化性质

纠错
外观与性状:
无色透明液体
密度:
1.322
熔点:
-40ºC
沸点:
213ºC
闪点:
135ºC
折射率:
1.479-1.481
储存条件:
库房通风低温干燥,与食品原料、氧化剂分开储运

安全信息

纠错
  • 包装等级:III
  • 危险类别:6.1
  • 海关编码:2905590090
  • 危险品运输编码:UN 2689
  • 危险类别码:R23/24/25; R36; R39; R60
  • 安全说明:S26-S28-S36/37/39-S38-S45-S53
  • 危险品标志:T

生产方法及用途

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生产方法

1、由甘油经氯化而得。将甘油和乙酸加入反应锅,搅拌加热至90-95℃,通干燥的氯化氢气体,至反应液增重至150%(理论值)即为终点。减压蒸馏,得粗品。再分馏,收集128-132℃(1.33-2.67kPa)馏分得3-氯-1,2-丙二醇。
2、由环氧氯丙烷水解而得。将环氧氯丙烷加入反应锅内,搅拌,加入稀硫酸使反应液呈酸性,升温,回流1h,将所得产物减压精馏即得成品。原料消耗定额:环氧氯丙烷(>95%)1200kg/t、硫酸3kg/t。 精制方法:减压蒸馏精制。
3.制法: 于装有搅拌器、温度计、滴液漏斗、回流冷凝器的反应瓶中,加入水120mL,浓硫酸1mL,加入至80℃,慢慢滴加环氧氯丙烷①...

用途

医药中间体。

合成路线

查看更多 总计:49合成路线
  • 106-89-8

    环氧氯丙烷

  • ~97%

  • 96-24-2

    (±)-3-氯-1,2-丙二醇

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  • 94266-20-3

    sodium,N,N-bis(2-ethylhexyl)carbamodithioate

  • 106-20-7

    双(2-乙基己基)胺

  • ~92%

  • 96-24-2

    (±)-3-氯-1,2-丙二醇

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  • 107-18-6

    烯丙醇

  • ~77%

  • 96-24-2

    (±)-3-氯-1,2-丙二醇

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上下游产品

上游产品总计:5下游产品总计:5
上游产品 总计:39 查看更多
下游产品 总计:178 查看更多

MSDS

  • MSDS
纠错
第一部分:化学品名称
化学品中文名称:3-氯-1,2-丙二醇;3-氯-1,2-二羟基丙烷
化学品英文名称:3-Chloro-1,2-propanediol;Chlorhydrin
中文俗名或商品名:
Synonyms:
CAS No.:96-24-2
分子式:C3H7ClO2
分子量:110.55
第二部分:成分/组成信息
             纯化学品  混合物
             化学品名称:3-氯-1,2-丙二醇;3-氯-1,2-二羟基丙烷
有害物成分含量CAS No.
第三部分:危险性概述
危险性类别: 第6.1类 毒害品
侵入途径:吸入 食入 经皮吸收
健康危害:吸入、摄入或经皮肤吸收后会中毒。对肺、肝、肾和脑都有影响。吸入蒸气能产生恶心、头痛、呕吐、眩晕、昏迷等症状。吸入蒸气可致肺水肿,严重者可致死。
环境危害:
燃爆危险:
第四部分:急救措施
皮肤接触:用肥皂水及清水彻底冲洗。就医。
眼睛接触:拉开眼睑,用流动清水冲洗15分钟。就医。
吸入:脱离现场至空气新鲜处。呼吸困难时给输氧。呼吸停止时,立即进行人工呼吸。就医。
食入:误服者,饮适量温水,催吐。就医。
第五部分:消防措施
危险特性:遇明火、高热易燃。受高热分解,放出有毒的烟气。
有害燃烧产物:
灭火方法及灭火剂:雾状水、抗溶性泡沫、二氧化碳、干粉。
消防员的个体防护:
禁止使用的灭火剂:
闪点(℃):58
自燃温度(℃):
爆炸下限[%(V/V)]:
爆炸上限[%(V/V)]:
最小点火能(mJ):
爆燃点:
爆速:
最大燃爆压力(MPa):
建规火险分级:
第六部分:泄漏应急处理
应急处理:疏散泄漏污染区人员至安全区,禁止无关人员进入污染区,建议应急处理人员戴自给式呼吸器,穿化学防护服。不要直接接触泄漏物,用砂土、蛭石或其它惰性材料吸收,收集运至废物处理场所。用水刷洗泄漏污染区,对污染地带进行通风。如大量泄漏,利用围堤收容,然后收集、转移、回收或无害处理后废弃。
第七部分:操作处置与储存
操作注意事项:
储存注意事项:
第八部分:接触控制/个体防护
最高容许浓度:中 国 MAC:未制订标准前苏联 MAC:未制订标准美国TLV—TWA:未制订标准
监测方法:
工程控制:密闭操作,局部排风。尽可能机械化、自动化。
呼吸系统防护:可能接触其蒸气时,应该佩戴防毒口罩。紧急事态抢救或逃生时,佩戴自给式呼吸器。
眼睛防护:戴化学安全防护眼镜。
身体防护:穿相应的防护服。
手防护:戴防化学品手套。
其他防护:工作现场禁止吸烟、进食和饮水。工作后,淋浴更衣。保持良好的卫生习惯。避免高浓度吸入。
第九部分:理化特性
外观与性状:无色粘稠液体,有吸湿性。
pH:
熔点(℃):-40
沸点(℃):139/2.39kPa
相对密度(水=1):1.3218
相对蒸气密度(空气=1):
饱和蒸气压(kPa):0.133/83℃
燃烧热(kJ/mol):
临界温度(℃):
临界压力(MPa):
辛醇/水分配系数的对数值:
闪点(℃):58
引燃温度(℃):
爆炸上限%(V/V):
爆炸下限%(V/V):
分子式:C3H7ClO2
分子量:110.55
蒸发速率:
粘性:
溶解性:溶于水、甲醇、甘油、乙醚、丙酮、乙酸乙酯等。
主要用途:用作醋酸纤维素的溶剂,并用于制增塑剂、表面活性剂、染料、药物、甘油衍生物等。
第十部分:稳定性和反应活性
稳定性:在常温常压下 稳定
禁配物:强氧化剂、强碱。
避免接触的条件:光照、接触潮湿空气。
聚合危害:不能出现
分解产物:—氧化碳、二氧化碳、氯化氢。
第十一部分:毒理学资料
急性毒性:LD50:26mg/kg(大鼠经口) LC50:
急性中毒:
慢性中毒:
亚急性和慢性毒性:
刺激性:
致敏性:
致突变性:
致畸性:
致癌性:
第十二部分:生态学资料
生态毒理毒性:
生物降解性:
非生物降解性:
生物富集或生物积累性:
第十三部分:废弃处置
废弃物性质:
废弃处置方法:
废弃注意事项:
第十四部分:运输信息
危险货物编号:61586
UN编号:2689
包装标志:
包装类别:
包装方法:
运输注意事项:储存于阴凉、干燥、通风良好的库房。远离火种、热源。保持容器密封。防止受潮和雨淋。应与氧化剂、碱类、食用化工原料分开存放。不能与粮食、食物、种子、饲料、各种日用品混装、混运。储存间内的照明、通风等设施应
RETCS号:
IMDG规则页码:
第十五部分:法规信息
国内化学品安全管理法规:
国际化学品安全管理法规:
第十六部分:其他信息
参考文献:1.周国泰,化学危险品安全技术全书,化学工业出版社,1997 2.国家环保局有毒化学品管理办公室、北京化工研究院合编,化学品毒性法规环境数据手册,中国环境科学出版社.1992 3.Canadian Centre for Occupational Health and Safety,CHEMINFO Database.1998 4.Canadian Centre for Occupational Health and Safety, RTECS Database, 1989
填表时间:年月日
填表部门:
数据审核单位:
修改说明:
其他信息:5
MSDS修改日期:年月日

海关数据

查看详细

中国海关编码:

2905590090

概述:

2905590090 其他无环醇的卤化、磺化等衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

申报要素:

品名, 成分含量, 用途, 包装

Summary:

2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

图谱

核磁图谱
13C NMR : in CDCl3展开
13C NMR : in CDCl3收起

ppm   Int.  Assign. 
       71.90   954      1
       63.74  1000      2
       45.72   862      3 

红外图谱(IR)
IR : liquid film展开
IR : liquid film收起

质谱(MS/Mass)
Mass 展开
Mass 收起

Source Temperature: 280 °C
   Sample Temperature: 150 °C
   RESERVOIR, 75 eV

更多(±)-3-氯-1,2-丙二醇图谱参考资料

毒性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TY4025000
CHEMICAL NAME :
1,2-Propanediol, 3-chloro-
CAS REGISTRY NUMBER :
96-24-2
BEILSTEIN REFERENCE NO. :
0635684
LAST UPDATED :
199806
DATA ITEMS CITED :
59
MOLECULAR FORMULA :
C3-H7-Cl-O2
MOLECULAR WEIGHT :
110.55
WISWESSER LINE NOTATION :
Q1YQ1G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
26 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
125 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
160 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Behavioral - somnolence (general depressed activity) Behavioral - ataxia
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>90 ppm/4H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Gastrointestinal - changes in structure or function of salivary glands Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
73 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
82 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - general anesthetic
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
23700 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
34580 mg/kg/72W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - thyroid tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2500 ug/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2 mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
85500 ug/kg
SEX/DURATION :
male 9 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
100 mg/kg
SEX/DURATION :
male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
13200 ug/kg
SEX/DURATION :
male 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
150 mg/kg
SEX/DURATION :
male 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive - Paternal Effects - other effects on male
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
14 mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
24 mg/kg
SEX/DURATION :
male 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
90 mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
750 mg/kg
SEX/DURATION :
female 15 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
150 mg/kg
SEX/DURATION :
male 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
133 mg/kg
SEX/DURATION :
male 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
90 mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
70 mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
240 mg/kg
SEX/DURATION :
male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intratesticular
DOSE :
2667 ug/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intratesticular
DOSE :
15385 ug/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1260 mg/kg
SEX/DURATION :
male 42 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5600 mg/kg
SEX/DURATION :
male 40 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intratesticular
DOSE :
40 mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
24 mg/kg
SEX/DURATION :
male 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
25 mg/kg
SEX/DURATION :
male 25 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5 mg/kg
SEX/DURATION :
male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
350 mg/kg
SEX/DURATION :
male 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
280 mg/kg
SEX/DURATION :
male 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
132 mg/kg
SEX/DURATION :
female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
132 mg/kg
SEX/DURATION :
male 2 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
750 mg/kg
SEX/DURATION :
male 50 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
450 mg/kg
SEX/DURATION :
male 18 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
625 mg/kg
SEX/DURATION :
male 25 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - other effects on male Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
75 mg/kg
SEX/DURATION :
male 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
75 mg/kg
SEX/DURATION :
male 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
60 mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
Mutation test systems - not otherwise specified
TYPE OF TEST :
Sperm Morphology
TYPE OF TEST :
Sperm Morphology

MUTATION DATA

TEST SYSTEM :
Mammal - species unspecified
DOSE/DURATION :
692 mg/kg/30D
REFERENCE :
FOBGA8 Folia Biologica (Krakow). (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1953- Volume(issue)/page/year: 22,281,1974 *** REVIEWS *** TOXICOLOGY REVIEW LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 23,1625,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84042 No. of Facilities: 5 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 20 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84042 No. of Facilities: 43 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 2917 (estimated)

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