CAS号 128-21-2 - 3Beta-羟基-5-beta-妊娠-20-酮

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: 3Beta-羟基-5-beta-妊娠-20-酮

英文名称：3β-hydroxy-5β-pregnan-20-one

CAS：
128-21-2
分子式：C21H34O2

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3Beta-羟基-5-beta-妊娠-20-酮简介

Epipregnanolone, also known as 3β-Hydoxy-5β-pregnan-20-one or 3β,5β-tetrahydroprogesterone (3β,5β-THP), is an endogenous neurosteroid. It acts as a negative allosteric modulator of the GABAA receptor and reverses the effects of potentiators like allopregnanolone. Epipregnanolone is biosynthesized from progesterone by the actions of 5β-reductase and 3β-hydroxysteroid dehydrogenase, with 5β-dihydroprogesterone as the intermediate in this two-step transformation.
Epipregnanolone is not a progestogen itself, but via metabolization into other steroids, behaves indirectly as one.
The sulfate of epipreganolone, epipregnanolone sulfate, is a negative allosteric modulator of the NMDA receptor, and also acts as a TRPM3 channel activator.

3Beta-羟基-5-beta-妊娠-20-酮基本信息

中文名称	3Beta-羟基-5-beta-妊娠-20-酮	英文名称	3β-hydroxy-5β-pregnan-20-one
中文别名	查看更多中文别名	英文别名	3.β.-Hydroxy-5.β.-tetrahydroprogesterone; 3alpha-hydroxy-5beta-pregnan-20-one; 3beta-hydroxy-5beta-pregnan-20-one; Pregnan-20-one, 3-hydroxy-, (3β,5β)-; 5B-pregnan-3B-ol-20-one crystalline; 查看更多英文别名
CAS号	128-21-2	分子式	C21H34O2
分子量	318.49300	精确质量	318.25600
PSA	37.30000	LOGP	4.59520