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普罗替林

英文名称:protriptyline

CAS : 438-60-8 精确质量 : 263.16700
分子式 : C19H21N logP : 4.69280
分子量 : 263.37700 PSA : 12.03000

基本信息

纠错
中文名称:
普罗替林
英文名称:
protriptyline
英文别名:

DIBENZO(A,D)CYCLOHEPTENE-5-PROPYLAMINE,N-METHYL;

3-(dibenzo(a,d)cyclohepten-5-yl)propylmethylamine;

Triptil;

N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine;

Vivactil;

查看更多英文别名

CAS号:
438-60-8
分子式:
C19H21N
分子量:
263.37700
精确质量:
263.16700
PSA:
12.03000
LogP:
4.69280

物化性质

纠错
密度:
1.026 g/cm3
沸点:
407.7ºC at 760 mmHg
闪点:
198.3ºC

安全信息

纠错
  • 海关编码:2921499090

合成路线

查看更多 总计:4合成路线
  • 18506-04-2

    11-chloro-11H-dibenzo[1,2-a:1',2'-e][7]annulene

  • 438-60-8

    普罗替林

详细>>
  • 18029-54-4

    5-[3-(二甲基氨基)丙基]-5H-二苯并[a,d]环庚烯-5-醇

  • 438-60-8

    普罗替林

详细>>
  • 521-80-2

    5-[3-(二甲基氨基)丙基]-5H-二苯并[a,d]环庚烯

  • 438-60-8

    普罗替林

详细>>

上下游产品

上游产品总计:5下游产品总计:2
上游产品 总计:5 查看更多
  • 19071-94-4

    3-(5H-dibenzo[a,d][7]annulen-5-yl)propyl methanesulfonate

  • 74-89-5

    甲胺

  • 521-80-2

    5-[3-(二甲基氨基)丙基]-5H-二苯并[a,d]环庚烯

  • 18029-54-4

    5-[3-(二甲基氨基)丙基]-5H-二苯并[a,d]环庚烯-5-醇

  • 18506-04-2

    11-chloro-11H-dibenzo[1,2-a:1',2'-e][7]annulene

下游产品 总计:2 查看更多

海关数据

查看详细

中国海关编码:

2921499090

概述:

2921499090 其他芳香单胺及衍生物及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%

申报要素:

品名, 成分含量, 用途

Summary:

2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

毒性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HP1050000
CHEMICAL NAME :
5H-Dibenzo(a,d)cycloheptene-5-propylamine, N-methyl-
CAS REGISTRY NUMBER :
438-60-8
LAST UPDATED :
199612
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C19-H21-N
MOLECULAR WEIGHT :
263.41
WISWESSER LINE NOTATION :
L C676 BHJ B3M1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
240 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 25,519,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
42 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 25,519,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
269 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 25,519,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
67 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 25,519,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
192 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 25,519,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 17,65,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
310 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 25,519,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
8200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 25,519,1970 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
630 mg/kg/6W-I
TOXIC EFFECTS :
Cardiac - EKG changes not diagnostic of specified effects Cardiac - pulse rate increase, without fall in BP
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,1709,1980 *** REVIEWS *** TOXICOLOGY REVIEW IDPYAK Industrial Pharmacology. (Mount Kisco, NY) V.1-3, 1974-79. Discontinued. Volume(issue)/page/year: 2,209,1975

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